<i>Plasmodium falciparum</i> Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress

par Stephanie D. Nofal, Avnish Patel, Michael J. Blackman, Christian Flueck, David A. Baker
Publié 2021

Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress.

par Christine R Collins, Fiona Hackett, Malcolm Strath, Maria Penzo, Chrislaine Withers-Martinez, David A Baker, Michael J Blackman
Publié 2013

The Actinomyosin Motor Drives Malaria Parasite Red Blood Cell Invasion but Not Egress

par Abigail J. Perrin, Christine R. Collins, Matthew R. G. Russell, Lucy M. Collinson, David A. Baker, Michael J. Blackman
Publié 2018

High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites

par Maria Penzo, Laura de las Heras-Dueña, Lydia Mata-Cantero, Beatriz Diaz-Hernandez, Maria-Jesus Vazquez-Muñiz, Sonja Ghidelli-Disse, Gerard Drewes, Elena Fernandez-Alvaro, David A. Baker
Publié 2019

Malaria Parasite Schizont Egress Antigen-1 Plays an Essential Role in Nuclear Segregation during Schizogony

par Abigail J. Perrin, Claudine Bisson, Peter A. Faull, Matthew J. Renshaw, Rebecca A. Lees, Roland A. Fleck, Helen R. Saibil, Ambrosius P. Snijders, David A. Baker, Michael J. Blackman
Publié 2021

Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

par Hanwei Fang, Ana Rita Gomes, Natacha Klages, Paco Pino, Bohumil Maco, Eloise M. Walker, Zenon A. Zenonos, Fiona Angrisano, Jake Baum, Christian Doerig, David A. Baker, Oliver Billker, Mathieu Brochet
Publié 2018

Phosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca²⁺ signals at key decision points in the life cycle of malaria parasites.

par Mathieu Brochet, Mark O Collins, Terry K Smith, Eloise Thompson, Sarah Sebastian, Katrin Volkmann, Frank Schwach, Lia Chappell, Ana Rita Gomes, Matthew Berriman, Julian C Rayner, David A Baker, Jyoti Choudhary, Oliver Billker
Publié 2014

Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck.

par Katarina M Braun, Gage K Moreno, Peter J Halfmann, Emma B Hodcroft, David A Baker, Emma C Boehm, Andrea M Weiler, Amelia K Haj, Masato Hatta, Shiho Chiba, Tadashi Maemura, Yoshihiro Kawaoka, Katia Koelle, David H O'Connor, Thomas C Friedrich
Publié 2021

The <italic toggle="yes">Plasmodium falciparum</italic> Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation

par Ryan C. Henrici, Rachel L. Edwards, Martin Zoltner, Donelly A. van Schalkwyk, Melissa N. Hart, Franziska Mohring, Robert W. Moon, Stephanie D. Nofal, Avnish Patel, Christian Flueck, David A. Baker, Audrey R. Odom John, Mark C. Field, Colin J. Sutherland
Publié 2020

Antimalarial activity of primaquine operates via a two-step biochemical relay

par Grazia Camarda, Piyaporn Jirawatcharadech, Richard S. Priestley, Ahmed Saif, Sandra March, Michael H. L. Wong, Suet Leung, Alex B. Miller, David A. Baker, Pietro Alano, Mark J. I. Paine, Sangeeta N. Bhatia, Paul M. O’Neill, Stephen A. Ward, Giancarlo A. Biagini
Publié 2019

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

par David A. Baker, Lindsay B. Stewart, Jonathan M. Large, Paul W. Bowyer, Keith H. Ansell, María B. Jiménez-Díaz, Majida El Bakkouri, Kristian Birchall, Koen J. Dechering, Nathalie S. Bouloc, Peter J. Coombs, David Whalley, Denise J. Harding, Ela Smiljanic-Hurley, Mary C. Wheldon, Eloise M. Walker, Johannes T. Dessens, María José Lafuente, Laura M. Sanz, Francisco-Javier Gamo, Santiago B. Ferrer, Raymond Hui, Teun Bousema, Iñigo Angulo-Barturén, Andy T. Merritt, Simon L. Croft, Winston E. Gutteridge, Catherine A. Kettleborough, Simon A. Osborne
Publié 2017