CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy

by Siqi Chen, Jie Fan, Minghui Zhang, Lei Qin, Donye Dominguez, Alan Long, Gaoxiang Wang, Renqiang Ma, Huabin Li, Yi Zhang, Deyu Fang, Jeffrey Sosman, Bin Zhang
Published 2019

The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity

by Yuanming Xu, Fang Zhao, Quan Qiu, Kun Chen, Juncheng Wei, Qingfei Kong, Beixue Gao, Johanna Melo-Cardenas, Bin Zhang, Jinping Zhang, Jianxun Song, Donna D. Zhang, Jianing Zhang, Yunping Fan, Huabin Li, Deyu Fang
Published 2016

ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes

by Juncheng Wei, Yanzhi Yuan, Lu Chen, Yuanming Xu, Yuehui Zhang, Yajun Wang, Yanjie Yang, Clara Bien Peek, Lauren Diebold, Yi Yang, Beixue Gao, Chaozhi Jin, Johanna Melo-Cardenas, Navdeep S. Chandel, Donna D. Zhang, Hui Pan, Kezhong Zhang, Jian Wang, Fuchu He, Deyu Fang
Published 2018