Resolution of chronic inflammatory disease: universal and tissue-specific concepts

by Georg Schett, Markus F. Neurath
Published 2018

Deep learning methods allow fully automated segmentation of metacarpal bones to quantify volumetric bone mineral density

by Lukas Folle, Timo Meinderink, David Simon, Anna-Maria Liphardt, Gerhard Krönke, Georg Schett, Arnd Kleyer, Andreas Maier
Published 2021

Th2 and eosinophil responses suppress inflammatory arthritis

by Zhu Chen, Darja Andreev, Katharina Oeser, Branislav Krljanac, Axel Hueber, Arnd Kleyer, David Voehringer, Georg Schett, Aline Bozec
Published 2016

Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease

by Xianyi Meng, Bettina Grötsch, Yubin Luo, Karl Xaver Knaup, Michael Sean Wiesener, Xiao-Xiang Chen, Jonathan Jantsch, Simon Fillatreau, Georg Schett, Aline Bozec
Published 2018

The mitogen-activated protein kinase p38α regulates tubular damage in murine anti-glomerular basement membrane nephritis.

by Ralf Müller, Christoph Daniel, Christian Hugo, Kerstin Amann, Dirk Mielenz, Karlhans Endlich, Tobias Braun, Betty van der Veen, Peter Heeringa, Georg Schett, Jochen Zwerina
Published 2013

Systemic versus local adipokine expression differs in a combined obesity and osteoarthritis mouse model

by Marie-Lisa Hülser, Yubin Luo, Klaus Frommer, Rebecca Hasseli, Kernt Köhler, Magnus Diller, Lina Van Nie, Christoph Rummel, Martin Roderfeld, Elke Roeb, Georg Schett, Aline Bozec, Ulf Müller-Ladner, Elena Neumann
Published 2021

Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss

by Sébastien Lucas, Yasunori Omata, Jörg Hofmann, Martin Böttcher, Aida Iljazovic, Kerstin Sarter, Olivia Albrecht, Oscar Schulz, Brenda Krishnacoumar, Gerhard Krönke, Martin Herrmann, Dimitrios Mougiakakos, Till Strowig, Georg Schett, Mario M. Zaiss
Published 2018

Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis

by Debomita Chakraborty, Barbora Šumová, Tatjana Mallano, Chih-Wei Chen, Alfiya Distler, Christina Bergmann, Ingo Ludolph, Raymund E. Horch, Kolja Gelse, Andreas Ramming, Oliver Distler, Georg Schett, Ladislav Šenolt, Jörg H. W. Distler
Published 2017

Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis

by Isabelle Cambré, Djoere Gaublomme, Arne Burssens, Peggy Jacques, Nadia Schryvers, Amélie De Muynck, Leander Meuris, Stijn Lambrecht, Shea Carter, Pieter de Bleser, Yvan Saeys, Luc Van Hoorebeke, George Kollias, Matthias Mack, Paul Simoens, Rik Lories, Nico Callewaert, Georg Schett, Dirk Elewaut
Published 2018

IgA subclasses have different effector functions associated with distinct glycosylation profiles

by Ulrike Steffen, Carolien A. Koeleman, Maria V. Sokolova, Holger Bang, Arnd Kleyer, Jürgen Rech, Harald Unterweger, Martin Schicht, Fabian Garreis, Jonas Hahn, Fabian T. Andes, Fabian Hartmann, Madelaine Hahn, Aparna Mahajan, Friedrich Paulsen, Markus Hoffmann, Günter Lochnit, Luis E. Muñoz, Manfred Wuhrer, David Falck, Martin Herrmann, Georg Schett
Published 2020

TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy

by Ariella Zehender, Yi-Nan Li, Neng-Yu Lin, Adrian Stefanica, Julian Nüchel, Chih-Wei Chen, Hsiao-Han Hsu, Honglin Zhu, Xiao Ding, Jingang Huang, Lichong Shen, Andrea-Hermina Györfi, Alina Soare, Simon Rauber, Christina Bergmann, Andreas Ramming, Markus Plomann, Beate Eckes, Georg Schett, Jörg H. W. Distler
Published 2021

Proteomic Approaches to Defining Remission and the Risk of Relapse in Rheumatoid Arthritis

by Liam J. O’Neil, Liam J. O’Neil, Pingzhao Hu, Pingzhao Hu, Qian Liu, Qian Liu, Md. Mohaiminul Islam, Md. Mohaiminul Islam, Victor Spicer, Juergen Rech, Axel Hueber, Vidyanand Anaparti, Irene Smolik, Hani S. El-Gabalawy, Hani S. El-Gabalawy, Georg Schett, John A. Wilkins, John A. Wilkins
Published 2021

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis

by Ariella Zehender, Jingang Huang, Andrea-Hermina Györfi, Alexandru-Emil Matei, Thuong Trinh-Minh, Xiaohan Xu, Yi-Nan Li, Chih-Wei Chen, Jianping Lin, Clara Dees, Christian Beyer, Kolja Gelse, Zhong-Yin Zhang, Christina Bergmann, Andreas Ramming, Walter Birchmeier, Oliver Distler, Georg Schett, Jörg H. W. Distler
Published 2018

Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

by Moritz Leppkes, Christian Maueröder, Sebastian Hirth, Stefanie Nowecki, Claudia Günther, Ulrike Billmeier, Susanne Paulus, Mona Biermann, Luis E. Munoz, Markus Hoffmann, Dane Wildner, Andrew L. Croxford, Ari Waisman, Kerri Mowen, Dieter E. Jenne, Veit Krenn, Julia Mayerle, Markus M. Lerch, Georg Schett, Stefan Wirtz, Markus F. Neurath, Martin Herrmann, Christoph Becker
Published 2016

Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis

by Vugar Azizov, Katharina Dietel, Franziska Steffen, Kerstin Dürholz, Julia Meidenbauer, Sébastien Lucas, Michael Frech, Yasunori Omata, Narges Tajik, Lisa Knipfer, Anne Kolenbrander, Silvia Seubert, Dennis Lapuente, Maria V. Sokolova, Jörg Hofmann, Matthias Tenbusch, Andreas Ramming, Ulrike Steffen, Falk Nimmerjahn, Ralf Linker, Stefan Wirtz, Martin Herrmann, Vladimir Temchura, Kerstin Sarter, Georg Schett, Mario M. Zaiss
Published 2020

Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis

by Narges Tajik, Michael Frech, Oscar Schulz, Fabian Schälter, Sébastien Lucas, Vugar Azizov, Kerstin Dürholz, Franziska Steffen, Yasunori Omata, Andreas Rings, Marko Bertog, Aroldo Rizzo, Aida Iljazovic, Marijana Basic, Arnd Kleyer, Stephan Culemann, Gerhard Krönke, Yubin Luo, Klaus Überla, Udo S. Gaipl, Benjamin Frey, Till Strowig, Kerstin Sarter, Stephan C. Bischoff, Stefan Wirtz, Juan D. Cañete, Francesco Ciccia, Georg Schett, Mario M. Zaiss
Published 2020

Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion

by David Simon, Koray Tascilar, Gerhard Krönke, Arnd Kleyer, Mario M. Zaiss, Franz Heppt, Christine Meder, Raja Atreya, Entcho Klenske, Peter Dietrich, Abdullah Abdullah, Thorsten Kliem, Giulia Corte, Harriet Morf, Moritz Leppkes, Andreas E. Kremer, Andreas Ramming, Milena Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Clara Maier, Axel J. Hueber, Karin Manger, Bernhard Manger, Carola Berking, Matthias Tenbusch, Klaus Überla, Michael Sticherling, Markus F. Neurath, Georg Schett
Published 2020

Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections

by Alan Bénard, Anne Jacobsen, Maximilian Brunner, Christian Krautz, Bettina Klösch, Izabela Swierzy, Elisabeth Naschberger, Malgorzata J. Podolska, Dina Kouhestani, Paul David, Torsten Birkholz, Ixchel Castellanos, Denis Trufa, Horia Sirbu, Marcel Vetter, Andreas E. Kremer, Kai Hildner, Andreas Hecker, Fabian Edinger, Matthias Tenbusch, Petra Mühl-Zürbes, Alexander Steinkasserer, Enrico Richter, Hendrik Streeck, Marc M. Berger, Thorsten Brenner, Markus A. Weigand, Filip K. Swirski, Georg Schett, Robert Grützmann, Georg F. Weber
Published 2021

Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

by Paul A Lyons, James E Peters, Federico Alberici, James Liley, Richard M. R. Coulson, William Astle, Chiara Baldini, Francesco Bonatti, Maria C Cid, Heather Elding, Giacomo Emmi, Jörg Epplen, Loïc Guillevin, David R. W. Jayne, Tao Jiang, Iva Gunnarsson, Peter Lamprecht, Stephen Leslie, Mark A. Little, Davide Martorana, Frank Moosig, Thomas Neumann, Sophie Ohlsson, Stefanie Quickert, Giuseppe A. Ramirez, Barbara Rewerska, Georg Schett, Renato A. Sinico, Wojciech Szczeklik, Vladimir Tesar, Damjan Vukcevic, The European Vasculitis Genetics Consortium, Benjamin Terrier, Richard A Watts, Augusto Vaglio, Julia U Holle, Chris Wallace, Kenneth G. C. Smith
Published 2019