Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia

par Özgen Deniz, Mamataz Ahmed, Christopher D. Todd, Ana Rio-Machin, Mark A. Dawson, Miguel R. Branco
Publié 2020

A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells

par Lei Guo, Jia Li, Hongxiang Zeng, Anna G. Guzman, Tingting Li, Minjung Lee, Yubin Zhou, Margaret A. Goodell, Clifford Stephan, Peter J. A. Davies, Mark A Dawson, Deqiang Sun, Yun Huang
Publié 2020

Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy

par Michael Y. He, Michael M. Halford, Ruofei Liu, James P. Roy, Zoe L. Grant, Leigh Coultas, Niko Thio, Omer Gilan, Yih-Chih Chan, Mark A. Dawson, Marc G. Achen, Steven A. Stacker
Publié 2021

Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia

par Paul Yeh, Tane Hunter, Devbarna Sinha, Sarah Ftouni, Elise Wallach, Damian Jiang, Yih-Chih Chan, Stephen Q. Wong, Maria Joao Silva, Ravikiran Vedururu, Kenneth Doig, Enid Lam, Gisela Mir Arnau, Timothy Semple, Meaghan Wall, Andjelija Zivanovic, Rishu Agarwal, Pasquale Petrone, Kate Jones, David Westerman, Piers Blombery, John F. Seymour, Anthony T. Papenfuss, Mark A. Dawson, Constantine S. Tam, Sarah-Jane Dawson
Publié 2017

An Erg-driven transcriptional program controls B cell lymphopoiesis

par Ashley P. Ng, Hannah D. Coughlan, Soroor Hediyeh-zadeh, Kira Behrens, Timothy M. Johanson, Michael Sze Yuan Low, Charles C. Bell, Omer Gilan, Yih-Chih Chan, Andrew J. Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D. Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A. Dawson, Rhys S. Allan, Marco J. Herold, Kelly Rogers, David M. Tarlinton, Gordon K. Smyth, Melissa J. Davis, Stephen L. Nutt, Warren S. Alexander
Publié 2020

Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia

par Charles C. Bell, Katie A. Fennell, Yih-Chih Chan, Florian Rambow, Miriam M. Yeung, Dane Vassiliadis, Luis Lara, Paul Yeh, Luciano G. Martelotto, Aljosja Rogiers, Brandon E. Kremer, Olena Barbash, Helai P. Mohammad, Timothy M. Johanson, Marian L. Burr, Arindam Dhar, Natalie Karpinich, Luyi Tian, Dean S. Tyler, Laura MacPherson, Junwei Shi, Nathan Pinnawala, Chun Yew Fong, Anthony T. Papenfuss, Sean M. Grimmond, Sarah-Jane Dawson, Rhys S. Allan, Ryan G. Kruger, Christopher R. Vakoc, David L. Goode, Shalin H. Naik, Omer Gilan, Enid Y. N. Lam, Jean-Christophe Marine, Rab K. Prinjha, Mark A. Dawson
Publié 2019