Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins

par Guillaume Blanchet, Doria Alili, Adèle Protte, Gregory Upert, Nicolas Gilles, Livia Tepshi, Enrico A. Stura, Gilles Mourier, Denis Servent
Publié 2017

Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors.

par Carole Fruchart-Gaillard, Gilles Mourier, Guillaume Blanchet, Laura Vera, Nicolas Gilles, Renée Ménez, Elodie Marcon, Enrico A Stura, Denis Servent
Publié 2012

Orthosteric binding of ρ-Da1a, a natural peptide of snake venom interacting selectively with the α1A-adrenoceptor.

par Arhamatoulaye Maïga, Jon Merlin, Elodie Marcon, Céline Rouget, Maud Larregola, Bernard Gilquin, Carole Fruchart-Gaillard, Evelyne Lajeunesse, Charles Marchetti, Alain Lorphelin, Laurent Bellanger, Roger J Summers, Dana S Hutchinson, Bronwyn A Evans, Denis Servent, Nicolas Gilles
Publié 2013