(S) y (R) -N-BOC, O-Isopropiliden-Alfa-Metilserinales: utilización como precursores de productos de interés biológico
This report describes the behaviour of (S)- and (R)-N-Boc-N,O-isopropylidene-a-methylserinals, a-methyl homologues of the Garner's aldehyde, as chiral building blocks in the synthesis of different optically active organic compounds that contain quaternary carbon atoms. Likewise, we have explore...
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| Formato: | text (thesis) |
| Lenguaje: | spa |
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Universidad de La Rioja (España)
2003
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| Acceso en línea: | https://dialnet.unirioja.es/servlet/oaites?codigo=95 |
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| Sumario: | This report describes the behaviour of (S)- and (R)-N-Boc-N,O-isopropylidene-a-methylserinals, a-methyl homologues of the Garner's aldehyde, as chiral building blocks in the synthesis of different optically active organic compounds that contain quaternary carbon atoms. Likewise, we have explored the applications of these compounds in the asymmetric synthesis of several products of considerable importance as several a-methyl-a-amino acids and the 4-epi-L-vancosamina, carbohydrate of different glycopeptide antibiotics. Finally, we have attempted to extend this methodology to all sorts of compounds with a quaternary stereocentre that include an amine group. For this reason, we have developed a new synthetic strategy to achieve different a-substituted serines, starting materials of their respective a-alkyl-(aryl)-serinals. |
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