Implicaciones de la NDP reductasa en la progresión de las horquillas de replicación en Escherichia coli

NDP reductase is the only specific enzyme required for the enzymatic synthesis of the precursors of DNA and it is a part of the Nucleotides Synthesis Complex. In this work we have analysed the replication fork progression in a nrdA101 mutant, which has a thermosensitive NDP reductase. We have proved...

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Detalles Bibliográficos
Autor principal: Guarino Almeida, Estrella
Otros Autores: Jiménez Sánchez, Alfonso (Universidad de Extremadura)
Formato: text (thesis)
Lenguaje:spa
Publicado: Universidad de Extremadura (España) 2006
Acceso en línea:https://dialnet.unirioja.es/servlet/oaites?codigo=615
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Sumario:NDP reductase is the only specific enzyme required for the enzymatic synthesis of the precursors of DNA and it is a part of the Nucleotides Synthesis Complex. In this work we have analysed the replication fork progression in a nrdA101 mutant, which has a thermosensitive NDP reductase. We have proved that the Nucleotides Synthesis Complex and the Replication Complex are associated in a Replication Hyperstructure.