Atividade antiulcerogênica de Alcaloides Pirrolizidínicos obtidos a partir do Extrato Etanólico de Senecio brasiliensis: perspectivas de uma nova terapêutica preventiva e curativa das úlceras gástricas e duodenais
Senecio brasiliensis is a native plant from South América and is found mainly in Brazil. Popularly Senecio is knowed as Margaridinha, Flor-das-Almas, Tasneirinha and is very utilized by folk medicine to the treatment of gastrointestinal diseases. Phytochemical analysis showed the presence of Pyrroli...
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| Formato: | text (thesis) |
| Lenguaje: | por |
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Universidade Estadual de Campinas (Brasil)
2003
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| Acceso en línea: | https://dialnet.unirioja.es/servlet/oaites?codigo=18684 |
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| Sumario: | Senecio brasiliensis is a native plant from South América and is found mainly in Brazil. Popularly Senecio is knowed as Margaridinha, Flor-das-Almas, Tasneirinha and is very utilized by folk medicine to the treatment of gastrointestinal diseases. Phytochemical analysis showed the presence of Pyrrolizidine Alkaloids (Pas) from Senecio brasiliensis. This study have a objective the obtained of PAs extract and evaluated the antiulcerogenic activity of the PAs on Standard rodent models. Furthermore this study also evaluated the probable pharmacological mechanism(s) of the PAs. The results showed the antiulcerogenic activity on gastric and duodenal induced ulcerogenic lesions. The pharmacological mechanisms showed that PAs can be a quantitative and probable therapy alternative in the future. News assays are necessary to determinate the efficacy and safety of this drug. |
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