Characteristics of pulmonary microvascular structure in postnatal yaks

Abstract Yaks are typical plateau-adapted animals, however the microvascular changes and characteristics in their lungs after birth are still unclear. Pulmonary microvasculature characteristics and changes across age groups were analysed using morphological observation and molecular biology detectio...

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Autores principales:	Ruidong Wan, Ziqi Zhao, Min Zhao, Ke Hu, Jiaxin Zhai, Hongxian Yu, Qing Wei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/00019abe98ca428daf529e50a4930a17
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spelling	oai:doaj.org-article:00019abe98ca428daf529e50a4930a172021-12-02T17:23:47ZCharacteristics of pulmonary microvascular structure in postnatal yaks10.1038/s41598-021-97760-z2045-2322https://doaj.org/article/00019abe98ca428daf529e50a4930a172021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97760-zhttps://doaj.org/toc/2045-2322Abstract Yaks are typical plateau-adapted animals, however the microvascular changes and characteristics in their lungs after birth are still unclear. Pulmonary microvasculature characteristics and changes across age groups were analysed using morphological observation and molecular biology detection in yaks aged 1, 30 and 180 days old in addition to adults. Results: Our experiments demonstrated that yaks have fully developed pulmonary alveolar at birth but that interalveolar thickness increased with age. Immunofluorescence observations showed that microvessel density within the interalveolar septum in the yak gradually increased with age. In addition, transmission electron microscopy (TEM) results showed that the blood–air barrier of 1-day old and 30-days old yaks was significantly thicker than that observed at 180-days old and in adults (P < 0.05), which was caused by the thinning of the membrane of alveolar epithelial cells. Furthermore, Vegfa and Epas1 expression levels in 30-day old yaks were the highest in comparison to the other age groups (P < 0.05), whilst levels in adult yaks were the lowest (P < 0.05). The gradual increase in lung microvessel density can effectively satisfy the oxygen requirements of ageing yaks. In addition, these results suggest that the key period of yak lung development is from 30 to 180 days.Ruidong WanZiqi ZhaoMin ZhaoKe HuJiaxin ZhaiHongxian YuQing WeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ruidong Wan Ziqi Zhao Min Zhao Ke Hu Jiaxin Zhai Hongxian Yu Qing Wei Characteristics of pulmonary microvascular structure in postnatal yaks
description	Abstract Yaks are typical plateau-adapted animals, however the microvascular changes and characteristics in their lungs after birth are still unclear. Pulmonary microvasculature characteristics and changes across age groups were analysed using morphological observation and molecular biology detection in yaks aged 1, 30 and 180 days old in addition to adults. Results: Our experiments demonstrated that yaks have fully developed pulmonary alveolar at birth but that interalveolar thickness increased with age. Immunofluorescence observations showed that microvessel density within the interalveolar septum in the yak gradually increased with age. In addition, transmission electron microscopy (TEM) results showed that the blood–air barrier of 1-day old and 30-days old yaks was significantly thicker than that observed at 180-days old and in adults (P < 0.05), which was caused by the thinning of the membrane of alveolar epithelial cells. Furthermore, Vegfa and Epas1 expression levels in 30-day old yaks were the highest in comparison to the other age groups (P < 0.05), whilst levels in adult yaks were the lowest (P < 0.05). The gradual increase in lung microvessel density can effectively satisfy the oxygen requirements of ageing yaks. In addition, these results suggest that the key period of yak lung development is from 30 to 180 days.
format	article
author	Ruidong Wan Ziqi Zhao Min Zhao Ke Hu Jiaxin Zhai Hongxian Yu Qing Wei
author_facet	Ruidong Wan Ziqi Zhao Min Zhao Ke Hu Jiaxin Zhai Hongxian Yu Qing Wei
author_sort	Ruidong Wan
title	Characteristics of pulmonary microvascular structure in postnatal yaks
title_short	Characteristics of pulmonary microvascular structure in postnatal yaks
title_full	Characteristics of pulmonary microvascular structure in postnatal yaks
title_fullStr	Characteristics of pulmonary microvascular structure in postnatal yaks
title_full_unstemmed	Characteristics of pulmonary microvascular structure in postnatal yaks
title_sort	characteristics of pulmonary microvascular structure in postnatal yaks
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/00019abe98ca428daf529e50a4930a17
work_keys_str_mv	AT ruidongwan characteristicsofpulmonarymicrovascularstructureinpostnatalyaks AT ziqizhao characteristicsofpulmonarymicrovascularstructureinpostnatalyaks AT minzhao characteristicsofpulmonarymicrovascularstructureinpostnatalyaks AT kehu characteristicsofpulmonarymicrovascularstructureinpostnatalyaks AT jiaxinzhai characteristicsofpulmonarymicrovascularstructureinpostnatalyaks AT hongxianyu characteristicsofpulmonarymicrovascularstructureinpostnatalyaks AT qingwei characteristicsofpulmonarymicrovascularstructureinpostnatalyaks
_version_	1718380946415157248

Characteristics of pulmonary microvascular structure in postnatal yaks

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