Challenging hepatitis C-infected liver transplant patients

Madeleine Oliver,1 Christopher Chiodo Ortiz,2 Jorge Ortiz31University of Toledo College of Medicine, Toledo, OH, 2Bucknell University, Lewisburg, PA, 3Department of Transplant Surgery, University of Toledo Medical Center, Toledo, OH, USA Abstract: Caring for liver transplant patients suffering from...

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Autores principales:	Oliver M, Chiodo Ortiz C, Ortiz J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Liver transplant Hepatitis C Virus postoperative Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/000456100ab04af0bed6425c96ba1fb4
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spelling	oai:doaj.org-article:000456100ab04af0bed6425c96ba1fb42021-12-02T00:04:03ZChallenging hepatitis C-infected liver transplant patients1179-1535https://doaj.org/article/000456100ab04af0bed6425c96ba1fb42016-01-01T00:00:00Zhttps://www.dovepress.com/challenging-hepatitis-c-infected-liver-transplant-patients-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Madeleine Oliver,1 Christopher Chiodo Ortiz,2 Jorge Ortiz31University of Toledo College of Medicine, Toledo, OH, 2Bucknell University, Lewisburg, PA, 3Department of Transplant Surgery, University of Toledo Medical Center, Toledo, OH, USA Abstract: Caring for liver transplant patients suffering from chronic hepatitis C virus (HCV) infection is a challenging task for transplant surgeons and primary physicians alike. HCV is the leading cause of liver transplantation in the USA and comes with a myriad of complications that increase morbidity and mortality. This review focuses on patient follow-up, spanning from before the liver transplant occurs to the patient's long-term health. Pretransplant, both donor and recipient variables, must be carefully chosen to ensure optimal surgical success. Risk factors must be identified and HCV viral load must be reduced to a minimum. In addition to standard transplant complications, HCV patients suffer from additional problems, such as fibrosing cholestatic hepatitis and widespread viremia. Physicians must focus on the balance of immunosuppressive and antiviral medications, while considering possible side effects from these potent drugs. Over the years following surgery, physicians must identify any signs of failing liver health, as HCV-positive patients have an increased risk for cirrhosis and certain life-threatening malignancies. Keywords: liver transplant, hepatitis C virus, postoperative, cirrhosis, donor and recipient variables, viremiaOliver MChiodo Ortiz COrtiz JDove Medical PressarticleLiver transplantHepatitis C ViruspostoperativeDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol 2016, Iss Issue 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Liver transplant Hepatitis C Virus postoperative Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Liver transplant Hepatitis C Virus postoperative Diseases of the digestive system. Gastroenterology RC799-869 Oliver M Chiodo Ortiz C Ortiz J Challenging hepatitis C-infected liver transplant patients
description	Madeleine Oliver,1 Christopher Chiodo Ortiz,2 Jorge Ortiz31University of Toledo College of Medicine, Toledo, OH, 2Bucknell University, Lewisburg, PA, 3Department of Transplant Surgery, University of Toledo Medical Center, Toledo, OH, USA Abstract: Caring for liver transplant patients suffering from chronic hepatitis C virus (HCV) infection is a challenging task for transplant surgeons and primary physicians alike. HCV is the leading cause of liver transplantation in the USA and comes with a myriad of complications that increase morbidity and mortality. This review focuses on patient follow-up, spanning from before the liver transplant occurs to the patient's long-term health. Pretransplant, both donor and recipient variables, must be carefully chosen to ensure optimal surgical success. Risk factors must be identified and HCV viral load must be reduced to a minimum. In addition to standard transplant complications, HCV patients suffer from additional problems, such as fibrosing cholestatic hepatitis and widespread viremia. Physicians must focus on the balance of immunosuppressive and antiviral medications, while considering possible side effects from these potent drugs. Over the years following surgery, physicians must identify any signs of failing liver health, as HCV-positive patients have an increased risk for cirrhosis and certain life-threatening malignancies. Keywords: liver transplant, hepatitis C virus, postoperative, cirrhosis, donor and recipient variables, viremia
format	article
author	Oliver M Chiodo Ortiz C Ortiz J
author_facet	Oliver M Chiodo Ortiz C Ortiz J
author_sort	Oliver M
title	Challenging hepatitis C-infected liver transplant patients
title_short	Challenging hepatitis C-infected liver transplant patients
title_full	Challenging hepatitis C-infected liver transplant patients
title_fullStr	Challenging hepatitis C-infected liver transplant patients
title_full_unstemmed	Challenging hepatitis C-infected liver transplant patients
title_sort	challenging hepatitis c-infected liver transplant patients
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/000456100ab04af0bed6425c96ba1fb4
work_keys_str_mv	AT oliverm challenginghepatitiscinfectedlivertransplantpatients AT chiodoortizc challenginghepatitiscinfectedlivertransplantpatients AT ortizj challenginghepatitiscinfectedlivertransplantpatients
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Challenging hepatitis C-infected liver transplant patients

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