The upregulated scavenger receptor CD36 is associated with the progression of nontarget lesions after stent implantation in atherosclerotic rabbits

Ruijian Li,1–3,* Sumei Cui,1–3,* Youshun Xu,4 Junhui Xing,5 Li Xue,1–3 Yuguo Chen1–3 1Department of Emergency, Qilu Hospital, Shandong University, Jinan, China; 2Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Shando...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Li R, Cui S, Xu Y, Xing J, Xue L, Chen Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Inflammation Oxidative stress CD36 Atherosclerosis Stent Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/0004a18ba74147d3ab65acb6bc3a0ee5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0004a18ba74147d3ab65acb6bc3a0ee5
record_format	dspace
spelling	oai:doaj.org-article:0004a18ba74147d3ab65acb6bc3a0ee52021-12-02T04:28:59ZThe upregulated scavenger receptor CD36 is associated with the progression of nontarget lesions after stent implantation in atherosclerotic rabbits1178-7031https://doaj.org/article/0004a18ba74147d3ab65acb6bc3a0ee52018-11-01T00:00:00Zhttps://www.dovepress.com/the-upregulated-scavenger-receptor-cd36-is-associated-with-the-progres-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Ruijian Li,1–3,* Sumei Cui,1–3,* Youshun Xu,4 Junhui Xing,5 Li Xue,1–3 Yuguo Chen1–3 1Department of Emergency, Qilu Hospital, Shandong University, Jinan, China; 2Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Shandong University, Jinan, China; 3Key Laboratory of Cardiovascular Remodeling & Function Research, Chinese Ministry of Education & Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China; 4Qilu Medical College of Shandong University, Jinan, China; 5Department of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China *These authors contributed equally to this work Background: The incidence of recurrent cardiovascular events from the progression of nontarget lesions (NTLs) is high for percutaneous coronary intervention-treated patients. However, the underlying mechanisms have not been thoroughly elucidated. Methods: In this study, ten atherosclerotic rabbits with multiple plaques in the upper and lower segments of abdominal aorta (group A) were randomly divided into two subgroups: group A1 underwent intravascular ultrasound examination and stent implantation in the lower segments of the abdominal aorta (n=5), whereas group A2 was without stenting (n=5). Group B was a control group without balloon injury. The serum levels of high-sensitivity CRP, interleukin-6 (IL-6), oxidized low-density lipoprotein, and CD36 were assessed via ELISA at five time points between the 10th and 18th weeks. The upper abdominal aorta was examined via the immunohistochemical stain and Western blotting of matrix metallopeptidase 9 (MMP-9), CD36, IL-6, and tumor necrosis factor α. Results: As a result, we found that stent implantation aggravated serum levels of CD36, oxidative stress, and inflammatory cytokines. Meanwhile, the upper abdominal arterial plaque burden significantly increased after stenting by intravascular ultrasound. Immunohistochemistry and Western blotting showed that the local NTLs’ matrix metallopeptidase 9, CD36, IL-6, and tumor necrosis factor α expressions in group A1 were significantly higher than those in groups A2 and B (P<0.05–0.01). More importantly, a strong correlation was identified between CD36 expression and NTLs’ plaque burden before the rabbits were killed. Conclusion: Taken together, stent implantation accelerated inflammation, induced oxidative stress, and increased the NTLs’ progression, which were associated with the upregulated CD36 expression. Keywords: inflammation, oxidative stress, CD36, atherosclerosis, stentLi RCui SXu YXing JXue LChen YDove Medical PressarticleInflammationOxidative stressCD36AtherosclerosisStentPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 11, Pp 447-456 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Inflammation Oxidative stress CD36 Atherosclerosis Stent Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Inflammation Oxidative stress CD36 Atherosclerosis Stent Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Li R Cui S Xu Y Xing J Xue L Chen Y The upregulated scavenger receptor CD36 is associated with the progression of nontarget lesions after stent implantation in atherosclerotic rabbits
description	Ruijian Li,1–3,* Sumei Cui,1–3,* Youshun Xu,4 Junhui Xing,5 Li Xue,1–3 Yuguo Chen1–3 1Department of Emergency, Qilu Hospital, Shandong University, Jinan, China; 2Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Shandong University, Jinan, China; 3Key Laboratory of Cardiovascular Remodeling & Function Research, Chinese Ministry of Education & Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China; 4Qilu Medical College of Shandong University, Jinan, China; 5Department of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China *These authors contributed equally to this work Background: The incidence of recurrent cardiovascular events from the progression of nontarget lesions (NTLs) is high for percutaneous coronary intervention-treated patients. However, the underlying mechanisms have not been thoroughly elucidated. Methods: In this study, ten atherosclerotic rabbits with multiple plaques in the upper and lower segments of abdominal aorta (group A) were randomly divided into two subgroups: group A1 underwent intravascular ultrasound examination and stent implantation in the lower segments of the abdominal aorta (n=5), whereas group A2 was without stenting (n=5). Group B was a control group without balloon injury. The serum levels of high-sensitivity CRP, interleukin-6 (IL-6), oxidized low-density lipoprotein, and CD36 were assessed via ELISA at five time points between the 10th and 18th weeks. The upper abdominal aorta was examined via the immunohistochemical stain and Western blotting of matrix metallopeptidase 9 (MMP-9), CD36, IL-6, and tumor necrosis factor α. Results: As a result, we found that stent implantation aggravated serum levels of CD36, oxidative stress, and inflammatory cytokines. Meanwhile, the upper abdominal arterial plaque burden significantly increased after stenting by intravascular ultrasound. Immunohistochemistry and Western blotting showed that the local NTLs’ matrix metallopeptidase 9, CD36, IL-6, and tumor necrosis factor α expressions in group A1 were significantly higher than those in groups A2 and B (P<0.05–0.01). More importantly, a strong correlation was identified between CD36 expression and NTLs’ plaque burden before the rabbits were killed. Conclusion: Taken together, stent implantation accelerated inflammation, induced oxidative stress, and increased the NTLs’ progression, which were associated with the upregulated CD36 expression. Keywords: inflammation, oxidative stress, CD36, atherosclerosis, stent
format	article
author	Li R Cui S Xu Y Xing J Xue L Chen Y
author_facet	Li R Cui S Xu Y Xing J Xue L Chen Y
author_sort	Li R
title	The upregulated scavenger receptor CD36 is associated with the progression of nontarget lesions after stent implantation in atherosclerotic rabbits
title_short	The upregulated scavenger receptor CD36 is associated with the progression of nontarget lesions after stent implantation in atherosclerotic rabbits
title_full	The upregulated scavenger receptor CD36 is associated with the progression of nontarget lesions after stent implantation in atherosclerotic rabbits
title_fullStr	The upregulated scavenger receptor CD36 is associated with the progression of nontarget lesions after stent implantation in atherosclerotic rabbits
title_full_unstemmed	The upregulated scavenger receptor CD36 is associated with the progression of nontarget lesions after stent implantation in atherosclerotic rabbits
title_sort	upregulated scavenger receptor cd36 is associated with the progression of nontarget lesions after stent implantation in atherosclerotic rabbits
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/0004a18ba74147d3ab65acb6bc3a0ee5
work_keys_str_mv	AT lir theupregulatedscavengerreceptorcd36isassociatedwiththeprogressionofnontargetlesionsafterstentimplantationinatheroscleroticrabbits AT cuis theupregulatedscavengerreceptorcd36isassociatedwiththeprogressionofnontargetlesionsafterstentimplantationinatheroscleroticrabbits AT xuy theupregulatedscavengerreceptorcd36isassociatedwiththeprogressionofnontargetlesionsafterstentimplantationinatheroscleroticrabbits AT xingj theupregulatedscavengerreceptorcd36isassociatedwiththeprogressionofnontargetlesionsafterstentimplantationinatheroscleroticrabbits AT xuel theupregulatedscavengerreceptorcd36isassociatedwiththeprogressionofnontargetlesionsafterstentimplantationinatheroscleroticrabbits AT cheny theupregulatedscavengerreceptorcd36isassociatedwiththeprogressionofnontargetlesionsafterstentimplantationinatheroscleroticrabbits AT lir upregulatedscavengerreceptorcd36isassociatedwiththeprogressionofnontargetlesionsafterstentimplantationinatheroscleroticrabbits AT cuis upregulatedscavengerreceptorcd36isassociatedwiththeprogressionofnontargetlesionsafterstentimplantationinatheroscleroticrabbits AT xuy upregulatedscavengerreceptorcd36isassociatedwiththeprogressionofnontargetlesionsafterstentimplantationinatheroscleroticrabbits AT xingj upregulatedscavengerreceptorcd36isassociatedwiththeprogressionofnontargetlesionsafterstentimplantationinatheroscleroticrabbits AT xuel upregulatedscavengerreceptorcd36isassociatedwiththeprogressionofnontargetlesionsafterstentimplantationinatheroscleroticrabbits AT cheny upregulatedscavengerreceptorcd36isassociatedwiththeprogressionofnontargetlesionsafterstentimplantationinatheroscleroticrabbits
_version_	1718401166902034432

The upregulated scavenger receptor CD36 is associated with the progression of nontarget lesions after stent implantation in atherosclerotic rabbits

Ejemplares similares