Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis

An endothelial cell subtype, expressing endomucin and CD31, has been reported to couple angiogenesis with osteogenesis. Here, the authors show that loss of ZEB1 in these cells epigenetically suppresses Notch signaling, leading to impaired angiogenesis and osteogenesis, and that Zeb1 delivery via lip...

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Autores principales:	Rong Fu, Wen-Cong Lv, Ying Xu, Mu-Yun Gong, Xiao-Jie Chen, Nan Jiang, Yan Xu, Qing-Qiang Yao, Lei Di, Tao Lu, Li-Ming Wang, Ran Mo, Zhao-Qiu Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0008c8a0821849b1a3b09e3ea489eb66
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spelling	oai:doaj.org-article:0008c8a0821849b1a3b09e3ea489eb662021-12-02T17:33:13ZEndothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis10.1038/s41467-019-14076-32041-1723https://doaj.org/article/0008c8a0821849b1a3b09e3ea489eb662020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14076-3https://doaj.org/toc/2041-1723An endothelial cell subtype, expressing endomucin and CD31, has been reported to couple angiogenesis with osteogenesis. Here, the authors show that loss of ZEB1 in these cells epigenetically suppresses Notch signaling, leading to impaired angiogenesis and osteogenesis, and that Zeb1 delivery via liposomes ameliorates bone loss in osteoporotic miceRong FuWen-Cong LvYing XuMu-Yun GongXiao-Jie ChenNan JiangYan XuQing-Qiang YaoLei DiTao LuLi-Ming WangRan MoZhao-Qiu WuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rong Fu Wen-Cong Lv Ying Xu Mu-Yun Gong Xiao-Jie Chen Nan Jiang Yan Xu Qing-Qiang Yao Lei Di Tao Lu Li-Ming Wang Ran Mo Zhao-Qiu Wu Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis
description	An endothelial cell subtype, expressing endomucin and CD31, has been reported to couple angiogenesis with osteogenesis. Here, the authors show that loss of ZEB1 in these cells epigenetically suppresses Notch signaling, leading to impaired angiogenesis and osteogenesis, and that Zeb1 delivery via liposomes ameliorates bone loss in osteoporotic mice
format	article
author	Rong Fu Wen-Cong Lv Ying Xu Mu-Yun Gong Xiao-Jie Chen Nan Jiang Yan Xu Qing-Qiang Yao Lei Di Tao Lu Li-Ming Wang Ran Mo Zhao-Qiu Wu
author_facet	Rong Fu Wen-Cong Lv Ying Xu Mu-Yun Gong Xiao-Jie Chen Nan Jiang Yan Xu Qing-Qiang Yao Lei Di Tao Lu Li-Ming Wang Ran Mo Zhao-Qiu Wu
author_sort	Rong Fu
title	Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis
title_short	Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis
title_full	Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis
title_fullStr	Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis
title_full_unstemmed	Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis
title_sort	endothelial zeb1 promotes angiogenesis-dependent bone formation and reverses osteoporosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0008c8a0821849b1a3b09e3ea489eb66
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Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis

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