Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis

An endothelial cell subtype, expressing endomucin and CD31, has been reported to couple angiogenesis with osteogenesis. Here, the authors show that loss of ZEB1 in these cells epigenetically suppresses Notch signaling, leading to impaired angiogenesis and osteogenesis, and that Zeb1 delivery via lip...

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Autores principales: Rong Fu, Wen-Cong Lv, Ying Xu, Mu-Yun Gong, Xiao-Jie Chen, Nan Jiang, Yan Xu, Qing-Qiang Yao, Lei Di, Tao Lu, Li-Ming Wang, Ran Mo, Zhao-Qiu Wu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/0008c8a0821849b1a3b09e3ea489eb66
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