RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury

Therapeutic hypothermia is a potent tool in the treatment of neonatal hypoxic-ischemic (HI) injury, yet the underlying mechanisms remain unclear. Here, authors demonstrate how the RNA-binding motif protein RBM3, which is induced by mild cooling while global translation rate is slowed down, contribut...

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Autores principales:	Xinzhou Zhu, Jingyi Yan, Catherine Bregere, Andrea Zelmer, Tessa Goerne, Josef P. Kapfhammer, Raphael Guzman, Sven Wellmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/00099bf8d81d43ab991574c74cdbdc99
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spelling	oai:doaj.org-article:00099bf8d81d43ab991574c74cdbdc992021-12-02T17:01:51ZRBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury10.1038/s41467-019-11870-x2041-1723https://doaj.org/article/00099bf8d81d43ab991574c74cdbdc992019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11870-xhttps://doaj.org/toc/2041-1723Therapeutic hypothermia is a potent tool in the treatment of neonatal hypoxic-ischemic (HI) injury, yet the underlying mechanisms remain unclear. Here, authors demonstrate how the RNA-binding motif protein RBM3, which is induced by mild cooling while global translation rate is slowed down, contributes substantially to neuroregeneration after adult HI injury, specifically in the subventricular zone and subgranular zone.Xinzhou ZhuJingyi YanCatherine BregereAndrea ZelmerTessa GoerneJosef P. KapfhammerRaphael GuzmanSven WellmannNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xinzhou Zhu Jingyi Yan Catherine Bregere Andrea Zelmer Tessa Goerne Josef P. Kapfhammer Raphael Guzman Sven Wellmann RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury
description	Therapeutic hypothermia is a potent tool in the treatment of neonatal hypoxic-ischemic (HI) injury, yet the underlying mechanisms remain unclear. Here, authors demonstrate how the RNA-binding motif protein RBM3, which is induced by mild cooling while global translation rate is slowed down, contributes substantially to neuroregeneration after adult HI injury, specifically in the subventricular zone and subgranular zone.
format	article
author	Xinzhou Zhu Jingyi Yan Catherine Bregere Andrea Zelmer Tessa Goerne Josef P. Kapfhammer Raphael Guzman Sven Wellmann
author_facet	Xinzhou Zhu Jingyi Yan Catherine Bregere Andrea Zelmer Tessa Goerne Josef P. Kapfhammer Raphael Guzman Sven Wellmann
author_sort	Xinzhou Zhu
title	RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury
title_short	RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury
title_full	RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury
title_fullStr	RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury
title_full_unstemmed	RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury
title_sort	rbm3 promotes neurogenesis in a niche-dependent manner via imp2-igf2 signaling pathway after hypoxic-ischemic brain injury
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/00099bf8d81d43ab991574c74cdbdc99
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RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury

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