The M235T polymorphism in the angiotensinogen gene is not a major risk factor for diabetic nephropathy; a meta-analysis

The M235T polymorphism in the angiotensinogen gene is not a major risk factor for diabetic nephropathy; a meta-analysis

Introduction: Diabetic nephropathy (DN) is the leading cause of chronic kidney disease in diabetes patients. The angiotensin AGT M235T gene polymorphism, which is linked to the renin-angiotensin-aldosterone system (RAAS), has been extensively studied in DN patients, but the results are still conflic...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Bhuneshwar Sahu, Shashikant Swarnakar, Henu Kumar Verma, Thavanati Parvathi Kumara Reddy, Smaranika Pattnaik, Bhaskar VKS Lakkakula
Formato: article
Lenguaje:EN
Publicado: Society of Diabetic Nephropathy Prevention 2022
Materias:
chronic kidney disease
end-stage renal disease
diabetic nephropathy
meta-analysis
Specialties of internal medicine
RC581-951
Infectious and parasitic diseases
RC109-216
Acceso en línea:https://doaj.org/article/000d6d4ef9d84d24ba3abfedd819e200
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:000d6d4ef9d84d24ba3abfedd819e200
record_format dspace
spelling oai:doaj.org-article:000d6d4ef9d84d24ba3abfedd819e2002021-11-16T10:42:14ZThe M235T polymorphism in the angiotensinogen gene is not a major risk factor for diabetic nephropathy; a meta-analysis2476-393410.34172/jpe.2022.15https://doaj.org/article/000d6d4ef9d84d24ba3abfedd819e2002022-01-01T00:00:00Zhttps://jprevepi.com/PDF/jpe-7-e15.pdfhttps://doaj.org/toc/2476-3934Introduction: Diabetic nephropathy (DN) is the leading cause of chronic kidney disease in diabetes patients. The angiotensin AGT M235T gene polymorphism, which is linked to the renin-angiotensin-aldosterone system (RAAS), has been extensively studied in DN patients, but the results are still conflicting. The current study’s goal is to conduct a meta-analysis to assess the relationship between AGT M235T gene polymorphism and DN susceptibility. Methods: Fourteen case-control studies related to AGT M235T polymorphism and DN were searched using PubMed, Web of Science and Google Scholar databases. Genotype data from the T2DM and T2DN groups were collected from all papers. The pooled odds ratio (OR) and 95 percent confidence interval (95% CI) were calculated employing a random-effects model to assess the relationship. Results: There were no statistically significant link between AGT M235T and DN risk in dominant (P=0.801, OR: 0.95; 95% CI: 0.66-1.38), allelic (P=0.933, OR: 1.01; 95% CI: 0.75-1.37) and recessive (P=0.374, OR: 1.21; 95% CI: 0.80-1.83) genetic models. Further, the stratified analysis based on ethnicity did not reveal significant link between AGT M235T and DN risk in Asian (Dom OR: 1.07; 95% CI: 0.63-1.82) and the Caucasian populations (Dom OR: 0.77; 95% CI: 0.49-1.21). In all three models, there was a high degree of heterogeneity between studies. Publication bias was not seen. Conclusion: Our findings suggest that the AGT gene M235T polymorphism does not contribute to DN risk. However, validation of this association will require multi-center and large population-based studies.Bhuneshwar SahuShashikant SwarnakarHenu Kumar VermaThavanati Parvathi Kumara ReddySmaranika PattnaikBhaskar VKS LakkakulaSociety of Diabetic Nephropathy Preventionarticlechronic kidney diseaseend-stage renal diseasediabetic nephropathymeta-analysisSpecialties of internal medicineRC581-951Infectious and parasitic diseasesRC109-216ENJournal of Preventive Epidemiology, Vol 7, Iss 1, Pp e15-e15 (2022)
institution DOAJ
collection DOAJ
language EN
topic chronic kidney disease
end-stage renal disease
diabetic nephropathy
meta-analysis
Specialties of internal medicine
RC581-951
Infectious and parasitic diseases
RC109-216
spellingShingle chronic kidney disease
end-stage renal disease
diabetic nephropathy
meta-analysis
Specialties of internal medicine
RC581-951
Infectious and parasitic diseases
RC109-216
Bhuneshwar Sahu
Shashikant Swarnakar
Henu Kumar Verma
Thavanati Parvathi Kumara Reddy
Smaranika Pattnaik
Bhaskar VKS Lakkakula
The M235T polymorphism in the angiotensinogen gene is not a major risk factor for diabetic nephropathy; a meta-analysis
description Introduction: Diabetic nephropathy (DN) is the leading cause of chronic kidney disease in diabetes patients. The angiotensin AGT M235T gene polymorphism, which is linked to the renin-angiotensin-aldosterone system (RAAS), has been extensively studied in DN patients, but the results are still conflicting. The current study’s goal is to conduct a meta-analysis to assess the relationship between AGT M235T gene polymorphism and DN susceptibility. Methods: Fourteen case-control studies related to AGT M235T polymorphism and DN were searched using PubMed, Web of Science and Google Scholar databases. Genotype data from the T2DM and T2DN groups were collected from all papers. The pooled odds ratio (OR) and 95 percent confidence interval (95% CI) were calculated employing a random-effects model to assess the relationship. Results: There were no statistically significant link between AGT M235T and DN risk in dominant (P=0.801, OR: 0.95; 95% CI: 0.66-1.38), allelic (P=0.933, OR: 1.01; 95% CI: 0.75-1.37) and recessive (P=0.374, OR: 1.21; 95% CI: 0.80-1.83) genetic models. Further, the stratified analysis based on ethnicity did not reveal significant link between AGT M235T and DN risk in Asian (Dom OR: 1.07; 95% CI: 0.63-1.82) and the Caucasian populations (Dom OR: 0.77; 95% CI: 0.49-1.21). In all three models, there was a high degree of heterogeneity between studies. Publication bias was not seen. Conclusion: Our findings suggest that the AGT gene M235T polymorphism does not contribute to DN risk. However, validation of this association will require multi-center and large population-based studies.
format article
author Bhuneshwar Sahu
Shashikant Swarnakar
Henu Kumar Verma
Thavanati Parvathi Kumara Reddy
Smaranika Pattnaik
Bhaskar VKS Lakkakula
author_facet Bhuneshwar Sahu
Shashikant Swarnakar
Henu Kumar Verma
Thavanati Parvathi Kumara Reddy
Smaranika Pattnaik
Bhaskar VKS Lakkakula
author_sort Bhuneshwar Sahu
title The M235T polymorphism in the angiotensinogen gene is not a major risk factor for diabetic nephropathy; a meta-analysis
title_short The M235T polymorphism in the angiotensinogen gene is not a major risk factor for diabetic nephropathy; a meta-analysis
title_full The M235T polymorphism in the angiotensinogen gene is not a major risk factor for diabetic nephropathy; a meta-analysis
title_fullStr The M235T polymorphism in the angiotensinogen gene is not a major risk factor for diabetic nephropathy; a meta-analysis
title_full_unstemmed The M235T polymorphism in the angiotensinogen gene is not a major risk factor for diabetic nephropathy; a meta-analysis
title_sort m235t polymorphism in the angiotensinogen gene is not a major risk factor for diabetic nephropathy; a meta-analysis
publisher Society of Diabetic Nephropathy Prevention
publishDate 2022
url https://doaj.org/article/000d6d4ef9d84d24ba3abfedd819e200
work_keys_str_mv AT bhuneshwarsahu them235tpolymorphismintheangiotensinogengeneisnotamajorriskfactorfordiabeticnephropathyametaanalysis
AT shashikantswarnakar them235tpolymorphismintheangiotensinogengeneisnotamajorriskfactorfordiabeticnephropathyametaanalysis
AT henukumarverma them235tpolymorphismintheangiotensinogengeneisnotamajorriskfactorfordiabeticnephropathyametaanalysis
AT thavanatiparvathikumarareddy them235tpolymorphismintheangiotensinogengeneisnotamajorriskfactorfordiabeticnephropathyametaanalysis
AT smaranikapattnaik them235tpolymorphismintheangiotensinogengeneisnotamajorriskfactorfordiabeticnephropathyametaanalysis
AT bhaskarvkslakkakula them235tpolymorphismintheangiotensinogengeneisnotamajorriskfactorfordiabeticnephropathyametaanalysis
AT bhuneshwarsahu m235tpolymorphismintheangiotensinogengeneisnotamajorriskfactorfordiabeticnephropathyametaanalysis
AT shashikantswarnakar m235tpolymorphismintheangiotensinogengeneisnotamajorriskfactorfordiabeticnephropathyametaanalysis
AT henukumarverma m235tpolymorphismintheangiotensinogengeneisnotamajorriskfactorfordiabeticnephropathyametaanalysis
AT thavanatiparvathikumarareddy m235tpolymorphismintheangiotensinogengeneisnotamajorriskfactorfordiabeticnephropathyametaanalysis
AT smaranikapattnaik m235tpolymorphismintheangiotensinogengeneisnotamajorriskfactorfordiabeticnephropathyametaanalysis
AT bhaskarvkslakkakula m235tpolymorphismintheangiotensinogengeneisnotamajorriskfactorfordiabeticnephropathyametaanalysis
_version_ 1718426522137657344

Ejemplares similares