A Protective Role for Arachidonic Acid Metabolites against Advanced Colorectal Adenoma in a Phase III Trial of Selenium

Oxylipins derived from arachidonic acid (ARA) have been implicated in the development of colorectal adenomas and colorectal cancer. The primary purpose of this work was to determine the relationship between plasma levels of oxylipins and colorectal adenoma characteristics at study entry, as well as...

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Autores principales:	Jessica A. Martinez, Meghan B. Skiba, H-H. Sherry Chow, Wade M. Chew, Kathylynn Saboda, Peter Lance, Nathan A. Ellis, Elizabeth T. Jacobs
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	colorectal adenoma oxylipins selenium colorectal neoplasia colon cancer ARA Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/000e7631911548d59dadd69eaad10a9b
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spelling	oai:doaj.org-article:000e7631911548d59dadd69eaad10a9b2021-11-25T18:34:52ZA Protective Role for Arachidonic Acid Metabolites against Advanced Colorectal Adenoma in a Phase III Trial of Selenium10.3390/nu131138772072-6643https://doaj.org/article/000e7631911548d59dadd69eaad10a9b2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3877https://doaj.org/toc/2072-6643Oxylipins derived from arachidonic acid (ARA) have been implicated in the development of colorectal adenomas and colorectal cancer. The primary purpose of this work was to determine the relationship between plasma levels of oxylipins and colorectal adenoma characteristics at study entry, as well as with the development of a new adenoma during follow-up within a Phase III adenoma prevention clinical trial with selenium (Sel). Secondarily, we sought to determine whether the selenium intervention influenced plasma oxylipin levels. Four oxylipins were quantified in stored plasma samples from a subset of Sel study subjects (<i>n</i> = 256) at baseline and at 12-months. There were significantly lower odds of an advanced adenoma at baseline with higher prostaglandin E<sub>2</sub> (PGE<sub>2</sub>), with an OR (95% CI) of 0.55 (0.33–0.92), and with 5-hydroxyeicosatetraenoic acid (5-HETE) ((0.53 (0.33–0.94)); and of a large adenoma with higher PGE<sub>2</sub> ((0.52 (0.31–0.87)). In contrast, no associations were observed between any oxylipin and the development of a new adenoma during follow-up. Selenium supplementation was associated with a significantly smaller increase in 5-HETE after 12 months compared to the placebo, though no other results were statistically significant. The ARA-derived oxylipins may have a role in the progression of non-advanced adenoma to advanced, but not with the development of a new adenoma.Jessica A. MartinezMeghan B. SkibaH-H. Sherry ChowWade M. ChewKathylynn SabodaPeter LanceNathan A. EllisElizabeth T. JacobsMDPI AGarticlecolorectal adenomaoxylipinsseleniumcolorectal neoplasiacolon cancerARANutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3877, p 3877 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal adenoma oxylipins selenium colorectal neoplasia colon cancer ARA Nutrition. Foods and food supply TX341-641
spellingShingle	colorectal adenoma oxylipins selenium colorectal neoplasia colon cancer ARA Nutrition. Foods and food supply TX341-641 Jessica A. Martinez Meghan B. Skiba H-H. Sherry Chow Wade M. Chew Kathylynn Saboda Peter Lance Nathan A. Ellis Elizabeth T. Jacobs A Protective Role for Arachidonic Acid Metabolites against Advanced Colorectal Adenoma in a Phase III Trial of Selenium
description	Oxylipins derived from arachidonic acid (ARA) have been implicated in the development of colorectal adenomas and colorectal cancer. The primary purpose of this work was to determine the relationship between plasma levels of oxylipins and colorectal adenoma characteristics at study entry, as well as with the development of a new adenoma during follow-up within a Phase III adenoma prevention clinical trial with selenium (Sel). Secondarily, we sought to determine whether the selenium intervention influenced plasma oxylipin levels. Four oxylipins were quantified in stored plasma samples from a subset of Sel study subjects (<i>n</i> = 256) at baseline and at 12-months. There were significantly lower odds of an advanced adenoma at baseline with higher prostaglandin E<sub>2</sub> (PGE<sub>2</sub>), with an OR (95% CI) of 0.55 (0.33–0.92), and with 5-hydroxyeicosatetraenoic acid (5-HETE) ((0.53 (0.33–0.94)); and of a large adenoma with higher PGE<sub>2</sub> ((0.52 (0.31–0.87)). In contrast, no associations were observed between any oxylipin and the development of a new adenoma during follow-up. Selenium supplementation was associated with a significantly smaller increase in 5-HETE after 12 months compared to the placebo, though no other results were statistically significant. The ARA-derived oxylipins may have a role in the progression of non-advanced adenoma to advanced, but not with the development of a new adenoma.
format	article
author	Jessica A. Martinez Meghan B. Skiba H-H. Sherry Chow Wade M. Chew Kathylynn Saboda Peter Lance Nathan A. Ellis Elizabeth T. Jacobs
author_facet	Jessica A. Martinez Meghan B. Skiba H-H. Sherry Chow Wade M. Chew Kathylynn Saboda Peter Lance Nathan A. Ellis Elizabeth T. Jacobs
author_sort	Jessica A. Martinez
title	A Protective Role for Arachidonic Acid Metabolites against Advanced Colorectal Adenoma in a Phase III Trial of Selenium
title_short	A Protective Role for Arachidonic Acid Metabolites against Advanced Colorectal Adenoma in a Phase III Trial of Selenium
title_full	A Protective Role for Arachidonic Acid Metabolites against Advanced Colorectal Adenoma in a Phase III Trial of Selenium
title_fullStr	A Protective Role for Arachidonic Acid Metabolites against Advanced Colorectal Adenoma in a Phase III Trial of Selenium
title_full_unstemmed	A Protective Role for Arachidonic Acid Metabolites against Advanced Colorectal Adenoma in a Phase III Trial of Selenium
title_sort	protective role for arachidonic acid metabolites against advanced colorectal adenoma in a phase iii trial of selenium
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/000e7631911548d59dadd69eaad10a9b
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A Protective Role for Arachidonic Acid Metabolites against Advanced Colorectal Adenoma in a Phase III Trial of Selenium

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