Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors

DNA methylation plays an important role in silencing transposable elements. Here the authors find that loss of DNMT1 and DNA methylation leads to transcriptional activation and chromatin remodelling of evolutionarily young—hominoid-specific —LINE-1 elements which then act as alternative promoters fo...

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Autores principales:	Marie E Jönsson, Per Ludvik Brattås, Charlotte Gustafsson, Rebecca Petri, David Yudovich, Karolina Pircs, Shana Verschuere, Sofia Madsen, Jenny Hansson, Jonas Larsson, Robert Månsson, Alexander Meissner, Johan Jakobsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0010acf9352643ada962a4e79869dc29
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spelling	oai:doaj.org-article:0010acf9352643ada962a4e79869dc292021-12-02T14:38:44ZActivation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors10.1038/s41467-019-11150-82041-1723https://doaj.org/article/0010acf9352643ada962a4e79869dc292019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11150-8https://doaj.org/toc/2041-1723DNA methylation plays an important role in silencing transposable elements. Here the authors find that loss of DNMT1 and DNA methylation leads to transcriptional activation and chromatin remodelling of evolutionarily young—hominoid-specific —LINE-1 elements which then act as alternative promoters for neuronal genes.Marie E JönssonPer Ludvik BrattåsCharlotte GustafssonRebecca PetriDavid YudovichKarolina PircsShana VerschuereSofia MadsenJenny HanssonJonas LarssonRobert MånssonAlexander MeissnerJohan JakobssonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marie E Jönsson Per Ludvik Brattås Charlotte Gustafsson Rebecca Petri David Yudovich Karolina Pircs Shana Verschuere Sofia Madsen Jenny Hansson Jonas Larsson Robert Månsson Alexander Meissner Johan Jakobsson Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors
description	DNA methylation plays an important role in silencing transposable elements. Here the authors find that loss of DNMT1 and DNA methylation leads to transcriptional activation and chromatin remodelling of evolutionarily young—hominoid-specific —LINE-1 elements which then act as alternative promoters for neuronal genes.
format	article
author	Marie E Jönsson Per Ludvik Brattås Charlotte Gustafsson Rebecca Petri David Yudovich Karolina Pircs Shana Verschuere Sofia Madsen Jenny Hansson Jonas Larsson Robert Månsson Alexander Meissner Johan Jakobsson
author_facet	Marie E Jönsson Per Ludvik Brattås Charlotte Gustafsson Rebecca Petri David Yudovich Karolina Pircs Shana Verschuere Sofia Madsen Jenny Hansson Jonas Larsson Robert Månsson Alexander Meissner Johan Jakobsson
author_sort	Marie E Jönsson
title	Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors
title_short	Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors
title_full	Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors
title_fullStr	Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors
title_full_unstemmed	Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors
title_sort	activation of neuronal genes via line-1 elements upon global dna demethylation in human neural progenitors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0010acf9352643ada962a4e79869dc29
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Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors

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