Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson’s Disease

Parkinson’s disease (PD) is a neurodegenerative disorder closely related to immunity. An important aspect of the pathogenesis of PD is the interaction between α-synuclein and a series of immune cells. Studies have shown that accumulation of α-synuclein can induce an autoimmune response that accelera...

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Auteurs principaux:	Ruichen Su, Tian Zhou
Format:	article
Langue:	EN
Publié:	Frontiers Media S.A. 2021
Sujets:	Parkinson’s disease (PD) α-synuclein microglia T cells therapeutics Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Accès en ligne:	https://doaj.org/article/0010b87d05e84d249d15557ca42e2e65
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spelling	oai:doaj.org-article:0010b87d05e84d249d15557ca42e2e652021-11-05T08:36:16ZAlpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson’s Disease1663-436510.3389/fnagi.2021.769506https://doaj.org/article/0010b87d05e84d249d15557ca42e2e652021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.769506/fullhttps://doaj.org/toc/1663-4365Parkinson’s disease (PD) is a neurodegenerative disorder closely related to immunity. An important aspect of the pathogenesis of PD is the interaction between α-synuclein and a series of immune cells. Studies have shown that accumulation of α-synuclein can induce an autoimmune response that accelerates the progression of PD. This study discusses the mechanisms underlying the interaction between α-synuclein and the immune system. During the development of PD, abnormally accumulated α-synuclein becomes an autoimmune antigen that binds to Toll-like receptors (TLRs) that activate microglia, which differentiate into the microglia type 1 (M1) subtype. The microglia activate intracellular inflammatory pathways, induce the release of proinflammatory cytokines, and promote the differentiation of cluster of differentiation 4 + (CD4 +) T cells into proinflammatory T helper type 1 (Th1) and T helper type 17 (Th17) subtypes. Given the important role of α-synuclein in the immune system of the patients with PD, identifying potential targets of immunotherapy related to α-synuclein is critical for slowing disease progression. An enhanced understanding of immune-associated mechanisms in PD can guide the development of associated therapeutic strategies in the future.Ruichen SuTian ZhouFrontiers Media S.A.articleParkinson’s disease (PD)α-synucleinmicrogliaT cellstherapeuticsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson’s disease (PD) α-synuclein microglia T cells therapeutics Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Parkinson’s disease (PD) α-synuclein microglia T cells therapeutics Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Ruichen Su Tian Zhou Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson’s Disease
description	Parkinson’s disease (PD) is a neurodegenerative disorder closely related to immunity. An important aspect of the pathogenesis of PD is the interaction between α-synuclein and a series of immune cells. Studies have shown that accumulation of α-synuclein can induce an autoimmune response that accelerates the progression of PD. This study discusses the mechanisms underlying the interaction between α-synuclein and the immune system. During the development of PD, abnormally accumulated α-synuclein becomes an autoimmune antigen that binds to Toll-like receptors (TLRs) that activate microglia, which differentiate into the microglia type 1 (M1) subtype. The microglia activate intracellular inflammatory pathways, induce the release of proinflammatory cytokines, and promote the differentiation of cluster of differentiation 4 + (CD4 +) T cells into proinflammatory T helper type 1 (Th1) and T helper type 17 (Th17) subtypes. Given the important role of α-synuclein in the immune system of the patients with PD, identifying potential targets of immunotherapy related to α-synuclein is critical for slowing disease progression. An enhanced understanding of immune-associated mechanisms in PD can guide the development of associated therapeutic strategies in the future.
format	article
author	Ruichen Su Tian Zhou
author_facet	Ruichen Su Tian Zhou
author_sort	Ruichen Su
title	Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson’s Disease
title_short	Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson’s Disease
title_full	Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson’s Disease
title_fullStr	Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson’s Disease
title_full_unstemmed	Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson’s Disease
title_sort	alpha-synuclein induced immune cells activation and associated therapy in parkinson’s disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0010b87d05e84d249d15557ca42e2e65
work_keys_str_mv	AT ruichensu alphasynucleininducedimmunecellsactivationandassociatedtherapyinparkinsonsdisease AT tianzhou alphasynucleininducedimmunecellsactivationandassociatedtherapyinparkinsonsdisease
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Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson’s Disease

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