Polyphenols: From Theory to Practice

Background: The importance of polyphenols in human health is well known; these compounds are common in foods, such as fruits, vegetables, spices, extra virgin olive oil and wine. On the other hand, the different factors that modulate the biological activity of these compounds are less well known. Co...

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Autores principales:	Alberto Bertelli, Marco Biagi, Maddalena Corsini, Giulia Baini, Giorgio Cappellucci, Elisabetta Miraldi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	polyphenols biological properties antioxidant and antiviral activity bioavailability preclinical data Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/0011b79d697446f7b432aa9c8dcae302
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spelling	oai:doaj.org-article:0011b79d697446f7b432aa9c8dcae3022021-11-25T17:33:10ZPolyphenols: From Theory to Practice10.3390/foods101125952304-8158https://doaj.org/article/0011b79d697446f7b432aa9c8dcae3022021-10-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2595https://doaj.org/toc/2304-8158Background: The importance of polyphenols in human health is well known; these compounds are common in foods, such as fruits, vegetables, spices, extra virgin olive oil and wine. On the other hand, the different factors that modulate the biological activity of these compounds are less well known. Conceptualization of the work: In this review we took into account about 200 relevant and recent papers on the following topics: “polyphenols bioavailability”, “polyphenols matrix effect”, “food matrix effect”, “polyphenols-cytochromes interaction”, after having reviewed and updated information on chemical classification and main biological properties of polyphenols, such as the antioxidant, anti-radical and anti-inflammatory activity, together with the tricky link between in vitro tests and clinical trials. Key findings: the issue of polyphenols bioavailability and matrix effect should be better taken into account when health claims are referred to polyphenols, thus considering the matrix effect, enzymatic interactions, reactions with other foods or genetic or gender characteristics that could interfere. We also discovered that in vitro studies often underrate the role of phytocomplexes and thus we provided practical hints to describe a clearer way to approach an investigation on polyphenols for a more resounding transfer to their use in medicine.Alberto BertelliMarco BiagiMaddalena CorsiniGiulia BainiGiorgio CappellucciElisabetta MiraldiMDPI AGarticlepolyphenolsbiological propertiesantioxidant and antiviral activitybioavailabilitypreclinical dataChemical technologyTP1-1185ENFoods, Vol 10, Iss 2595, p 2595 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polyphenols biological properties antioxidant and antiviral activity bioavailability preclinical data Chemical technology TP1-1185
spellingShingle	polyphenols biological properties antioxidant and antiviral activity bioavailability preclinical data Chemical technology TP1-1185 Alberto Bertelli Marco Biagi Maddalena Corsini Giulia Baini Giorgio Cappellucci Elisabetta Miraldi Polyphenols: From Theory to Practice
description	Background: The importance of polyphenols in human health is well known; these compounds are common in foods, such as fruits, vegetables, spices, extra virgin olive oil and wine. On the other hand, the different factors that modulate the biological activity of these compounds are less well known. Conceptualization of the work: In this review we took into account about 200 relevant and recent papers on the following topics: “polyphenols bioavailability”, “polyphenols matrix effect”, “food matrix effect”, “polyphenols-cytochromes interaction”, after having reviewed and updated information on chemical classification and main biological properties of polyphenols, such as the antioxidant, anti-radical and anti-inflammatory activity, together with the tricky link between in vitro tests and clinical trials. Key findings: the issue of polyphenols bioavailability and matrix effect should be better taken into account when health claims are referred to polyphenols, thus considering the matrix effect, enzymatic interactions, reactions with other foods or genetic or gender characteristics that could interfere. We also discovered that in vitro studies often underrate the role of phytocomplexes and thus we provided practical hints to describe a clearer way to approach an investigation on polyphenols for a more resounding transfer to their use in medicine.
format	article
author	Alberto Bertelli Marco Biagi Maddalena Corsini Giulia Baini Giorgio Cappellucci Elisabetta Miraldi
author_facet	Alberto Bertelli Marco Biagi Maddalena Corsini Giulia Baini Giorgio Cappellucci Elisabetta Miraldi
author_sort	Alberto Bertelli
title	Polyphenols: From Theory to Practice
title_short	Polyphenols: From Theory to Practice
title_full	Polyphenols: From Theory to Practice
title_fullStr	Polyphenols: From Theory to Practice
title_full_unstemmed	Polyphenols: From Theory to Practice
title_sort	polyphenols: from theory to practice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0011b79d697446f7b432aa9c8dcae302
work_keys_str_mv	AT albertobertelli polyphenolsfromtheorytopractice AT marcobiagi polyphenolsfromtheorytopractice AT maddalenacorsini polyphenolsfromtheorytopractice AT giuliabaini polyphenolsfromtheorytopractice AT giorgiocappellucci polyphenolsfromtheorytopractice AT elisabettamiraldi polyphenolsfromtheorytopractice
_version_	1718412204470960128

Polyphenols: From Theory to Practice

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