Development and Validation of a Three-gene Prognostic Signature for Patients with Hepatocellular Carcinoma

Abstract Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide, because recurrence often occurs in most HCC patients undergoing hepatectomy. It is necessary to identify patients with high risk for recurrence and adopt effective therapies. An obstacle to monitor patien...

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Autores principales:	Binghua Li, Wendu Feng, Ouyang Luo, Tiancheng Xu, Yajuan Cao, Hongyan Wu, Decai Yu, Yitao Ding
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/00143853c4ef4ec2ba9214ccd9394d38
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spelling	oai:doaj.org-article:00143853c4ef4ec2ba9214ccd9394d382021-12-02T11:53:00ZDevelopment and Validation of a Three-gene Prognostic Signature for Patients with Hepatocellular Carcinoma10.1038/s41598-017-04811-52045-2322https://doaj.org/article/00143853c4ef4ec2ba9214ccd9394d382017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04811-5https://doaj.org/toc/2045-2322Abstract Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide, because recurrence often occurs in most HCC patients undergoing hepatectomy. It is necessary to identify patients with high risk for recurrence and adopt effective therapies. An obstacle to monitor patients at high risk for poor prognosis has been the lack of useful predictive biomarkers. Fortunately, recent progress in system biology allows to screen the biomarkers for HCC prognosis in a high-throughput manner. In this study, we performed systematic Kaplan-Meier survival analysis of the whole mRNA transcriptomics based on the Cancer Genome Atlas project (TCGA) and developed a three-gene prognostic signature composing of three genes UPB1, SOCS2 and RTN3. The model was validated in two independent microarray data sets retrieved from Gene Expression Omnibus (GEO) and the expression pattern of these three predictive genes in HCC was confirmed by western blot and immunohistochemistry with our HCC samples. In conclusion, our results showed that this three-gene signature has prognostic value for HCC patients.Binghua LiWendu FengOuyang LuoTiancheng XuYajuan CaoHongyan WuDecai YuYitao DingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Binghua Li Wendu Feng Ouyang Luo Tiancheng Xu Yajuan Cao Hongyan Wu Decai Yu Yitao Ding Development and Validation of a Three-gene Prognostic Signature for Patients with Hepatocellular Carcinoma
description	Abstract Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide, because recurrence often occurs in most HCC patients undergoing hepatectomy. It is necessary to identify patients with high risk for recurrence and adopt effective therapies. An obstacle to monitor patients at high risk for poor prognosis has been the lack of useful predictive biomarkers. Fortunately, recent progress in system biology allows to screen the biomarkers for HCC prognosis in a high-throughput manner. In this study, we performed systematic Kaplan-Meier survival analysis of the whole mRNA transcriptomics based on the Cancer Genome Atlas project (TCGA) and developed a three-gene prognostic signature composing of three genes UPB1, SOCS2 and RTN3. The model was validated in two independent microarray data sets retrieved from Gene Expression Omnibus (GEO) and the expression pattern of these three predictive genes in HCC was confirmed by western blot and immunohistochemistry with our HCC samples. In conclusion, our results showed that this three-gene signature has prognostic value for HCC patients.
format	article
author	Binghua Li Wendu Feng Ouyang Luo Tiancheng Xu Yajuan Cao Hongyan Wu Decai Yu Yitao Ding
author_facet	Binghua Li Wendu Feng Ouyang Luo Tiancheng Xu Yajuan Cao Hongyan Wu Decai Yu Yitao Ding
author_sort	Binghua Li
title	Development and Validation of a Three-gene Prognostic Signature for Patients with Hepatocellular Carcinoma
title_short	Development and Validation of a Three-gene Prognostic Signature for Patients with Hepatocellular Carcinoma
title_full	Development and Validation of a Three-gene Prognostic Signature for Patients with Hepatocellular Carcinoma
title_fullStr	Development and Validation of a Three-gene Prognostic Signature for Patients with Hepatocellular Carcinoma
title_full_unstemmed	Development and Validation of a Three-gene Prognostic Signature for Patients with Hepatocellular Carcinoma
title_sort	development and validation of a three-gene prognostic signature for patients with hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/00143853c4ef4ec2ba9214ccd9394d38
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Development and Validation of a Three-gene Prognostic Signature for Patients with Hepatocellular Carcinoma

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