The change of gut microbiota in MDD patients under SSRIs treatment

Abstract The alterations in the gut microbiota have been reported to be correlated with the development of depression. The purpose of this study was to investigate the changes of intestinal microbiota in depressed patients after antidepressant treatment. We recruited 30 MDD patients (MDD group) and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yang Shen, Xiao Yang, Gaofei Li, Jiayu Gao, Ying Liang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0016a89170534fbc8254b14ed0782a67
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0016a89170534fbc8254b14ed0782a67
record_format	dspace
spelling	oai:doaj.org-article:0016a89170534fbc8254b14ed0782a672021-12-02T17:55:13ZThe change of gut microbiota in MDD patients under SSRIs treatment10.1038/s41598-021-94481-12045-2322https://doaj.org/article/0016a89170534fbc8254b14ed0782a672021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94481-1https://doaj.org/toc/2045-2322Abstract The alterations in the gut microbiota have been reported to be correlated with the development of depression. The purpose of this study was to investigate the changes of intestinal microbiota in depressed patients after antidepressant treatment. We recruited 30 MDD patients (MDD group) and 30 healthy controls (control group). The MDD group received individualized treatment with escitalopram at a maximum dose of 20 mg/day. After depressive symptoms improved to a HAMD scale score > 50%, a fecal sample was collected again and used as the follow-up group. The differences of gut microbiota between patients and controls, the characteristics of gut microbiota under treatment and the potential differences in metabolic functions were thus investigated. The Firmicutes/Bacteroidetes ratio was significantly different within three groups, and the ratio of follow-up group was significantly lower than those of the other two groups. Alpha diversity was significantly higher in MDD group than those of the other groups, and the alpha diversity was not significantly different between control and follow-up groups. The beta diversity of some patients resembled participants in the control group. The metabolic function of gut microbiota after treatment was still different from that of the control group. This study suggests that the intestinal flora of depressed patients has a tendency to return to normal under escitalopram treatment.Yang ShenXiao YangGaofei LiJiayu GaoYing LiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yang Shen Xiao Yang Gaofei Li Jiayu Gao Ying Liang The change of gut microbiota in MDD patients under SSRIs treatment
description	Abstract The alterations in the gut microbiota have been reported to be correlated with the development of depression. The purpose of this study was to investigate the changes of intestinal microbiota in depressed patients after antidepressant treatment. We recruited 30 MDD patients (MDD group) and 30 healthy controls (control group). The MDD group received individualized treatment with escitalopram at a maximum dose of 20 mg/day. After depressive symptoms improved to a HAMD scale score > 50%, a fecal sample was collected again and used as the follow-up group. The differences of gut microbiota between patients and controls, the characteristics of gut microbiota under treatment and the potential differences in metabolic functions were thus investigated. The Firmicutes/Bacteroidetes ratio was significantly different within three groups, and the ratio of follow-up group was significantly lower than those of the other two groups. Alpha diversity was significantly higher in MDD group than those of the other groups, and the alpha diversity was not significantly different between control and follow-up groups. The beta diversity of some patients resembled participants in the control group. The metabolic function of gut microbiota after treatment was still different from that of the control group. This study suggests that the intestinal flora of depressed patients has a tendency to return to normal under escitalopram treatment.
format	article
author	Yang Shen Xiao Yang Gaofei Li Jiayu Gao Ying Liang
author_facet	Yang Shen Xiao Yang Gaofei Li Jiayu Gao Ying Liang
author_sort	Yang Shen
title	The change of gut microbiota in MDD patients under SSRIs treatment
title_short	The change of gut microbiota in MDD patients under SSRIs treatment
title_full	The change of gut microbiota in MDD patients under SSRIs treatment
title_fullStr	The change of gut microbiota in MDD patients under SSRIs treatment
title_full_unstemmed	The change of gut microbiota in MDD patients under SSRIs treatment
title_sort	change of gut microbiota in mdd patients under ssris treatment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0016a89170534fbc8254b14ed0782a67
work_keys_str_mv	AT yangshen thechangeofgutmicrobiotainmddpatientsunderssristreatment AT xiaoyang thechangeofgutmicrobiotainmddpatientsunderssristreatment AT gaofeili thechangeofgutmicrobiotainmddpatientsunderssristreatment AT jiayugao thechangeofgutmicrobiotainmddpatientsunderssristreatment AT yingliang thechangeofgutmicrobiotainmddpatientsunderssristreatment AT yangshen changeofgutmicrobiotainmddpatientsunderssristreatment AT xiaoyang changeofgutmicrobiotainmddpatientsunderssristreatment AT gaofeili changeofgutmicrobiotainmddpatientsunderssristreatment AT jiayugao changeofgutmicrobiotainmddpatientsunderssristreatment AT yingliang changeofgutmicrobiotainmddpatientsunderssristreatment
_version_	1718379085800931328

The change of gut microbiota in MDD patients under SSRIs treatment

Ejemplares similares