Functional Connectivity Density with Frequency-Dependent Changes in Patients with Diffuse Axonal Injury: A Resting-State Functional Magnetic Resonance Imaging Study

Guojin Xia,1,2 Zhenzhen Hu,3 Fuqing Zhou,1,2 Wenfeng Duan,1,2 Min Wang,1,2 Honghan Gong,1,2 Yulin He,1,2 Yanxing Guan4 1Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi, People’s Republic of China; 2Jiangxi Province Medical Imaging Research Institute,...

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Autores principales:	Xia G, Hu Z, Zhou F, Duan W, Wang M, Gong H, He Y, Guan Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	diffuse axonal injury functional connectivity density functional magnetic resonance imaging frequency bands Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/00190a6b47df4333badc59cdae835dac
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spelling	oai:doaj.org-article:00190a6b47df4333badc59cdae835dac2021-12-02T15:19:08ZFunctional Connectivity Density with Frequency-Dependent Changes in Patients with Diffuse Axonal Injury: A Resting-State Functional Magnetic Resonance Imaging Study1178-2021https://doaj.org/article/00190a6b47df4333badc59cdae835dac2020-11-01T00:00:00Zhttps://www.dovepress.com/functional-connectivity-density-with-frequency-dependent-changes-in-pa-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Guojin Xia,1,2 Zhenzhen Hu,3 Fuqing Zhou,1,2 Wenfeng Duan,1,2 Min Wang,1,2 Honghan Gong,1,2 Yulin He,1,2 Yanxing Guan4 1Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi, People’s Republic of China; 2Jiangxi Province Medical Imaging Research Institute, Jiangxi, People’s Republic of China; 3Department of Thoracic Oncology, Jiangxi Cancer Hospital, Jiangxi, People’s Republic of China; 4Department of Nuclear Medicine, The First Affiliated Hospital of Nanchang University, Jiangxi, People’s Republic of ChinaCorrespondence: Yulin He; Yanxing Guan 17 Yongwaizheng Street, Nanchang City, Jiangxi Province, People’s Republic of ChinaTel +86-791-88692585Email 33heyulin@163.com; yanxingguan2000@aliyun.comPurpose: We explored changes in spontaneous brain connectivity in patients with diffuse axonal injury (DAI), assessed via functional connectivity density (FCD) tests using different frequency bands.Patients and Methods: In all, 23 patients with DAI (17 males and 6 females) and 23 healthy controls (HCs; 17 males and 6 females) were included. Functional magnetic resonance imaging scans were performed when the participants were in a resting state and the FCD levels in three frequency bands (slow-4: 0.027– 0.073 Hz, slow-5: 0.01– 0.027 Hz, and typical: 0.01– 0.08 Hz) were measured. In addition, Pearson’s correlation coefficient was used to explore the relationship between clinical indices and brain regions with abnormal FCD values.Results: Compared to HCs, DAI patients had significantly greater FCD values in the right extranuclear/limbic lobe/cingulate gyrus and left limbic lobe/hippocampus/parahippocampal gyrus, and significantly lower FCD values in the left precuneus/posterior cingulate gyrus, in the slow-4 band. In the slow-5 band, the DAI patients had higher FCD values in the left inferior temporal gyrus/superior temporal gyrus, left parahippocampal gyrus/limbic lobe, left extranuclear/cingulate gyrus, and right medial frontal gyrus, and lower values in the right inferior frontal gyrus, right inferior parietal lobule, and left cingulate gyrus/limbic lobe. Moreover, compared to HCs, the values in the typical band were higher in the right extranuclear/limbic lobe/hippocampus/parahippocampal gyrus, but were significantly lower in the right precuneus/posterior cingulate gyrus and right inferior parietal lobule/supramarginal gyrus. The abnormal FCD values of these brain regions were linearly correlated with different clinical scale scores.Conclusion: DAI patients had abnormal FCD values in various brain regions, indicating disruption to the brain functional network. Moreover, the values were frequency dependent. Our results provide new evidence for the pathogenesis of functional impairment and may explain the neuropathological or compensatory mechanism of the disease.Keywords: diffuse axonal injury, functional connectivity density, functional magnetic resonance imaging, frequency bandsXia GHu ZZhou FDuan WWang MGong HHe YGuan YDove Medical Pressarticlediffuse axonal injuryfunctional connectivity densityfunctional magnetic resonance imagingfrequency bandsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 2733-2742 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diffuse axonal injury functional connectivity density functional magnetic resonance imaging frequency bands Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	diffuse axonal injury functional connectivity density functional magnetic resonance imaging frequency bands Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Xia G Hu Z Zhou F Duan W Wang M Gong H He Y Guan Y Functional Connectivity Density with Frequency-Dependent Changes in Patients with Diffuse Axonal Injury: A Resting-State Functional Magnetic Resonance Imaging Study
description	Guojin Xia,1,2 Zhenzhen Hu,3 Fuqing Zhou,1,2 Wenfeng Duan,1,2 Min Wang,1,2 Honghan Gong,1,2 Yulin He,1,2 Yanxing Guan4 1Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi, People’s Republic of China; 2Jiangxi Province Medical Imaging Research Institute, Jiangxi, People’s Republic of China; 3Department of Thoracic Oncology, Jiangxi Cancer Hospital, Jiangxi, People’s Republic of China; 4Department of Nuclear Medicine, The First Affiliated Hospital of Nanchang University, Jiangxi, People’s Republic of ChinaCorrespondence: Yulin He; Yanxing Guan 17 Yongwaizheng Street, Nanchang City, Jiangxi Province, People’s Republic of ChinaTel +86-791-88692585Email 33heyulin@163.com; yanxingguan2000@aliyun.comPurpose: We explored changes in spontaneous brain connectivity in patients with diffuse axonal injury (DAI), assessed via functional connectivity density (FCD) tests using different frequency bands.Patients and Methods: In all, 23 patients with DAI (17 males and 6 females) and 23 healthy controls (HCs; 17 males and 6 females) were included. Functional magnetic resonance imaging scans were performed when the participants were in a resting state and the FCD levels in three frequency bands (slow-4: 0.027– 0.073 Hz, slow-5: 0.01– 0.027 Hz, and typical: 0.01– 0.08 Hz) were measured. In addition, Pearson’s correlation coefficient was used to explore the relationship between clinical indices and brain regions with abnormal FCD values.Results: Compared to HCs, DAI patients had significantly greater FCD values in the right extranuclear/limbic lobe/cingulate gyrus and left limbic lobe/hippocampus/parahippocampal gyrus, and significantly lower FCD values in the left precuneus/posterior cingulate gyrus, in the slow-4 band. In the slow-5 band, the DAI patients had higher FCD values in the left inferior temporal gyrus/superior temporal gyrus, left parahippocampal gyrus/limbic lobe, left extranuclear/cingulate gyrus, and right medial frontal gyrus, and lower values in the right inferior frontal gyrus, right inferior parietal lobule, and left cingulate gyrus/limbic lobe. Moreover, compared to HCs, the values in the typical band were higher in the right extranuclear/limbic lobe/hippocampus/parahippocampal gyrus, but were significantly lower in the right precuneus/posterior cingulate gyrus and right inferior parietal lobule/supramarginal gyrus. The abnormal FCD values of these brain regions were linearly correlated with different clinical scale scores.Conclusion: DAI patients had abnormal FCD values in various brain regions, indicating disruption to the brain functional network. Moreover, the values were frequency dependent. Our results provide new evidence for the pathogenesis of functional impairment and may explain the neuropathological or compensatory mechanism of the disease.Keywords: diffuse axonal injury, functional connectivity density, functional magnetic resonance imaging, frequency bands
format	article
author	Xia G Hu Z Zhou F Duan W Wang M Gong H He Y Guan Y
author_facet	Xia G Hu Z Zhou F Duan W Wang M Gong H He Y Guan Y
author_sort	Xia G
title	Functional Connectivity Density with Frequency-Dependent Changes in Patients with Diffuse Axonal Injury: A Resting-State Functional Magnetic Resonance Imaging Study
title_short	Functional Connectivity Density with Frequency-Dependent Changes in Patients with Diffuse Axonal Injury: A Resting-State Functional Magnetic Resonance Imaging Study
title_full	Functional Connectivity Density with Frequency-Dependent Changes in Patients with Diffuse Axonal Injury: A Resting-State Functional Magnetic Resonance Imaging Study
title_fullStr	Functional Connectivity Density with Frequency-Dependent Changes in Patients with Diffuse Axonal Injury: A Resting-State Functional Magnetic Resonance Imaging Study
title_full_unstemmed	Functional Connectivity Density with Frequency-Dependent Changes in Patients with Diffuse Axonal Injury: A Resting-State Functional Magnetic Resonance Imaging Study
title_sort	functional connectivity density with frequency-dependent changes in patients with diffuse axonal injury: a resting-state functional magnetic resonance imaging study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/00190a6b47df4333badc59cdae835dac
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Functional Connectivity Density with Frequency-Dependent Changes in Patients with Diffuse Axonal Injury: A Resting-State Functional Magnetic Resonance Imaging Study

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