Protection of calves by a prefusion-stabilized bovine RSV F vaccine

Respiratory disease: A bovine model for respiratory syncytial virus vaccines Researchers have produced a vaccine that protects against bovine respiratory syncytial virus (bRSV) in calves, with implications for humans. An international team comprising Geraldine Taylor, The Pirbright Institute, UK, Da...

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Autores principales:	Baoshan Zhang, Lei Chen, Chiara Silacci, Michelle Thom, Jeffrey C. Boyington, Aliaksandr Druz, M. Gordon Joyce, Efrain Guzman, Wing- Pui Kong, Yen-Ting Lai, Guillaume B. E. Stewart-Jones, Yaroslav Tsybovsky, Yongping Yang, Tongqing Zhou, Ulrich Baxa, John R. Mascola, Davide Corti, Antonio Lanzavecchia, Geraldine Taylor, Peter D. Kwong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/001a5cd8bf13451aaee8ecd1a3d59fa6
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spelling	oai:doaj.org-article:001a5cd8bf13451aaee8ecd1a3d59fa62021-12-02T12:30:33ZProtection of calves by a prefusion-stabilized bovine RSV F vaccine10.1038/s41541-017-0005-92059-0105https://doaj.org/article/001a5cd8bf13451aaee8ecd1a3d59fa62017-03-01T00:00:00Zhttps://doi.org/10.1038/s41541-017-0005-9https://doaj.org/toc/2059-0105Respiratory disease: A bovine model for respiratory syncytial virus vaccines Researchers have produced a vaccine that protects against bovine respiratory syncytial virus (bRSV) in calves, with implications for humans. An international team comprising Geraldine Taylor, The Pirbright Institute, UK, Davide Corti and Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland, and Peter Kwong, Vaccine Research Center, NIAID, NIH, United States, and their teams constructed the subunit vaccine from an engineered bRSVfusion (F) glycoprotein that protected challenged calves by generating a highly protective immune response. This approach allays some of the dangers of whole-virus vaccines. The results warrant further investigation, as current bRSV vaccines have significant downsides.Moreover, as the engineered bRSV F glycoprotein is structurally and reactively similar to the prefusion-stabilized human RSV (hRSV) F glycoprotein, the findings highlight potential benefits of similar vaccines in humans, as no licensed hRSV vaccine is currently available.Baoshan ZhangLei ChenChiara SilacciMichelle ThomJeffrey C. BoyingtonAliaksandr DruzM. Gordon JoyceEfrain GuzmanWing- Pui KongYen-Ting LaiGuillaume B. E. Stewart-JonesYaroslav TsybovskyYongping YangTongqing ZhouUlrich BaxaJohn R. MascolaDavide CortiAntonio LanzavecchiaGeraldine TaylorPeter D. KwongNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 2, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Baoshan Zhang Lei Chen Chiara Silacci Michelle Thom Jeffrey C. Boyington Aliaksandr Druz M. Gordon Joyce Efrain Guzman Wing- Pui Kong Yen-Ting Lai Guillaume B. E. Stewart-Jones Yaroslav Tsybovsky Yongping Yang Tongqing Zhou Ulrich Baxa John R. Mascola Davide Corti Antonio Lanzavecchia Geraldine Taylor Peter D. Kwong Protection of calves by a prefusion-stabilized bovine RSV F vaccine
description	Respiratory disease: A bovine model for respiratory syncytial virus vaccines Researchers have produced a vaccine that protects against bovine respiratory syncytial virus (bRSV) in calves, with implications for humans. An international team comprising Geraldine Taylor, The Pirbright Institute, UK, Davide Corti and Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland, and Peter Kwong, Vaccine Research Center, NIAID, NIH, United States, and their teams constructed the subunit vaccine from an engineered bRSVfusion (F) glycoprotein that protected challenged calves by generating a highly protective immune response. This approach allays some of the dangers of whole-virus vaccines. The results warrant further investigation, as current bRSV vaccines have significant downsides.Moreover, as the engineered bRSV F glycoprotein is structurally and reactively similar to the prefusion-stabilized human RSV (hRSV) F glycoprotein, the findings highlight potential benefits of similar vaccines in humans, as no licensed hRSV vaccine is currently available.
format	article
author	Baoshan Zhang Lei Chen Chiara Silacci Michelle Thom Jeffrey C. Boyington Aliaksandr Druz M. Gordon Joyce Efrain Guzman Wing- Pui Kong Yen-Ting Lai Guillaume B. E. Stewart-Jones Yaroslav Tsybovsky Yongping Yang Tongqing Zhou Ulrich Baxa John R. Mascola Davide Corti Antonio Lanzavecchia Geraldine Taylor Peter D. Kwong
author_facet	Baoshan Zhang Lei Chen Chiara Silacci Michelle Thom Jeffrey C. Boyington Aliaksandr Druz M. Gordon Joyce Efrain Guzman Wing- Pui Kong Yen-Ting Lai Guillaume B. E. Stewart-Jones Yaroslav Tsybovsky Yongping Yang Tongqing Zhou Ulrich Baxa John R. Mascola Davide Corti Antonio Lanzavecchia Geraldine Taylor Peter D. Kwong
author_sort	Baoshan Zhang
title	Protection of calves by a prefusion-stabilized bovine RSV F vaccine
title_short	Protection of calves by a prefusion-stabilized bovine RSV F vaccine
title_full	Protection of calves by a prefusion-stabilized bovine RSV F vaccine
title_fullStr	Protection of calves by a prefusion-stabilized bovine RSV F vaccine
title_full_unstemmed	Protection of calves by a prefusion-stabilized bovine RSV F vaccine
title_sort	protection of calves by a prefusion-stabilized bovine rsv f vaccine
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/001a5cd8bf13451aaee8ecd1a3d59fa6
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Protection of calves by a prefusion-stabilized bovine RSV F vaccine

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