Sarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation Tool

Sarcopenia is a skeletal muscle disorder characterized by reduced muscle mass, strength, and performance. Muscle ultrasound can be helpful in assessing muscle mass, quality, and architecture, and thus possibly useful for diagnosing or screening sarcopenia. The objective of this study was to evaluate...

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Autores principales:	Massimiliano Leigheb, Alessandro de Sire, Matteo Colangelo, Domenico Zagaria, Federico Alberto Grassi, Ottavio Rena, Patrizio Conte, Pierluigi Neri, Alessandro Carriero, Gian Mauro Sacchetti, Fabio Penna, Giuseppina Caretti, Elisabetta Ferraro
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sarcopenia ultrasonography muscle muscle thickness muscle stiffness Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/001ae096e7824884835b0f699ea67503
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spelling	oai:doaj.org-article:001ae096e7824884835b0f699ea675032021-11-25T17:22:09ZSarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation Tool10.3390/diagnostics111121582075-4418https://doaj.org/article/001ae096e7824884835b0f699ea675032021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2158https://doaj.org/toc/2075-4418Sarcopenia is a skeletal muscle disorder characterized by reduced muscle mass, strength, and performance. Muscle ultrasound can be helpful in assessing muscle mass, quality, and architecture, and thus possibly useful for diagnosing or screening sarcopenia. The objective of this study was to evaluate the reliability of ultrasound assessment of tibialis anterior muscle in sarcopenia diagnosis. We included subjects undergoing total or partial hip replacement, comparing measures with a healthy control group. We measured the following parameters: tibialis anterior muscle thickness, echogenicity, architecture, stiffness, skeletal muscle index (SMI), hand grip strength, and sarcopenia related quality of life evaluated through the SarQoL questionnaire. We included 33 participants with a mean age of 54.97 ± 23.91 years. In the study group we found reduced tibialis anterior muscle thickness compared to the healthy control group (19.49 ± 4.92 vs. 28.94 ± 3.63 mm, <i>p</i> < 0.05) with significant correlation with SarQoL values (r = 0.80, <i>p</i> < 0.05), dynamometer hand strength (r = 0.72, <i>p</i> < 0.05) and SMI (r = 0.76, <i>p</i> < 0.05). Moreover, we found reduced stiffness (32.21 ± 12.31 vs. 27.07 ± 8.04 Kpa, <i>p</i> < 0.05). AUC measures of ROC curves were 0.89 predicting reduced muscle strength, and 0.97 predicting reduced SMI for tibialis anterior muscle thickness, while they were 0.73 and 0.85, respectively, for muscle stiffness. Our findings showed that ultrasound assessment of tibialis anterior muscle might be considered a reliable measurement tool to evaluate sarcopenia.Massimiliano LeighebAlessandro de SireMatteo ColangeloDomenico ZagariaFederico Alberto GrassiOttavio RenaPatrizio ContePierluigi NeriAlessandro CarrieroGian Mauro SacchettiFabio PennaGiuseppina CarettiElisabetta FerraroMDPI AGarticlesarcopeniaultrasonographymusclemuscle thicknessmuscle stiffnessMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2158, p 2158 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sarcopenia ultrasonography muscle muscle thickness muscle stiffness Medicine (General) R5-920
spellingShingle	sarcopenia ultrasonography muscle muscle thickness muscle stiffness Medicine (General) R5-920 Massimiliano Leigheb Alessandro de Sire Matteo Colangelo Domenico Zagaria Federico Alberto Grassi Ottavio Rena Patrizio Conte Pierluigi Neri Alessandro Carriero Gian Mauro Sacchetti Fabio Penna Giuseppina Caretti Elisabetta Ferraro Sarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation Tool
description	Sarcopenia is a skeletal muscle disorder characterized by reduced muscle mass, strength, and performance. Muscle ultrasound can be helpful in assessing muscle mass, quality, and architecture, and thus possibly useful for diagnosing or screening sarcopenia. The objective of this study was to evaluate the reliability of ultrasound assessment of tibialis anterior muscle in sarcopenia diagnosis. We included subjects undergoing total or partial hip replacement, comparing measures with a healthy control group. We measured the following parameters: tibialis anterior muscle thickness, echogenicity, architecture, stiffness, skeletal muscle index (SMI), hand grip strength, and sarcopenia related quality of life evaluated through the SarQoL questionnaire. We included 33 participants with a mean age of 54.97 ± 23.91 years. In the study group we found reduced tibialis anterior muscle thickness compared to the healthy control group (19.49 ± 4.92 vs. 28.94 ± 3.63 mm, <i>p</i> < 0.05) with significant correlation with SarQoL values (r = 0.80, <i>p</i> < 0.05), dynamometer hand strength (r = 0.72, <i>p</i> < 0.05) and SMI (r = 0.76, <i>p</i> < 0.05). Moreover, we found reduced stiffness (32.21 ± 12.31 vs. 27.07 ± 8.04 Kpa, <i>p</i> < 0.05). AUC measures of ROC curves were 0.89 predicting reduced muscle strength, and 0.97 predicting reduced SMI for tibialis anterior muscle thickness, while they were 0.73 and 0.85, respectively, for muscle stiffness. Our findings showed that ultrasound assessment of tibialis anterior muscle might be considered a reliable measurement tool to evaluate sarcopenia.
format	article
author	Massimiliano Leigheb Alessandro de Sire Matteo Colangelo Domenico Zagaria Federico Alberto Grassi Ottavio Rena Patrizio Conte Pierluigi Neri Alessandro Carriero Gian Mauro Sacchetti Fabio Penna Giuseppina Caretti Elisabetta Ferraro
author_facet	Massimiliano Leigheb Alessandro de Sire Matteo Colangelo Domenico Zagaria Federico Alberto Grassi Ottavio Rena Patrizio Conte Pierluigi Neri Alessandro Carriero Gian Mauro Sacchetti Fabio Penna Giuseppina Caretti Elisabetta Ferraro
author_sort	Massimiliano Leigheb
title	Sarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation Tool
title_short	Sarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation Tool
title_full	Sarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation Tool
title_fullStr	Sarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation Tool
title_full_unstemmed	Sarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation Tool
title_sort	sarcopenia diagnosis: reliability of the ultrasound assessment of the tibialis anterior muscle as an alternative evaluation tool
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/001ae096e7824884835b0f699ea67503
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Sarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation Tool

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