High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli

High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli

Understanding evolutionary constraints in antibiotic resistance is crucial for prediction and control. Here, the authors use high-throughput laboratory evolution of Escherichia coli alongside machine learning to identify trade-off relationships associated with drug resistance.

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Autores principales: Tomoya Maeda, Junichiro Iwasawa, Hazuki Kotani, Natsue Sakata, Masako Kawada, Takaaki Horinouchi, Aki Sakai, Kumi Tanabe, Chikara Furusawa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/001bafcb32844840b1bb86e1b61340bb
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spelling oai:doaj.org-article:001bafcb32844840b1bb86e1b61340bb2021-12-02T14:16:41ZHigh-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli10.1038/s41467-020-19713-w2041-1723https://doaj.org/article/001bafcb32844840b1bb86e1b61340bb2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19713-whttps://doaj.org/toc/2041-1723Understanding evolutionary constraints in antibiotic resistance is crucial for prediction and control. Here, the authors use high-throughput laboratory evolution of Escherichia coli alongside machine learning to identify trade-off relationships associated with drug resistance.Tomoya MaedaJunichiro IwasawaHazuki KotaniNatsue SakataMasako KawadaTakaaki HorinouchiAki SakaiKumi TanabeChikara FurusawaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tomoya Maeda
Junichiro Iwasawa
Hazuki Kotani
Natsue Sakata
Masako Kawada
Takaaki Horinouchi
Aki Sakai
Kumi Tanabe
Chikara Furusawa
High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli
description Understanding evolutionary constraints in antibiotic resistance is crucial for prediction and control. Here, the authors use high-throughput laboratory evolution of Escherichia coli alongside machine learning to identify trade-off relationships associated with drug resistance.
format article
author Tomoya Maeda
Junichiro Iwasawa
Hazuki Kotani
Natsue Sakata
Masako Kawada
Takaaki Horinouchi
Aki Sakai
Kumi Tanabe
Chikara Furusawa
author_facet Tomoya Maeda
Junichiro Iwasawa
Hazuki Kotani
Natsue Sakata
Masako Kawada
Takaaki Horinouchi
Aki Sakai
Kumi Tanabe
Chikara Furusawa
author_sort Tomoya Maeda
title High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli
title_short High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli
title_full High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli
title_fullStr High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli
title_full_unstemmed High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli
title_sort high-throughput laboratory evolution reveals evolutionary constraints in escherichia coli
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/001bafcb32844840b1bb86e1b61340bb
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