ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine
ETNK1 mutations are recurrent in leukemia but how they contribute to oncogenesis is still unclear. Here, the authors show that ETNK1 mutations increase mitochondrial activity, ROS and H2AX levels and that these effects can be rescued upon phosphoethanolamine supplementation.
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Nature Portfolio
2020
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oai:doaj.org-article:001bd3e4deb94183af19e38c9741b2852021-12-02T10:48:10ZETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine10.1038/s41467-020-19721-w2041-1723https://doaj.org/article/001bd3e4deb94183af19e38c9741b2852020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19721-whttps://doaj.org/toc/2041-1723ETNK1 mutations are recurrent in leukemia but how they contribute to oncogenesis is still unclear. Here, the authors show that ETNK1 mutations increase mitochondrial activity, ROS and H2AX levels and that these effects can be rescued upon phosphoethanolamine supplementation.Diletta FontanaMario MauriRossella RensoMattia DocciIlaria CrespiaticoLisa M. RøstMi JangAntonio NiroDeborah D’AlibertiLuca MassiminoMayla BertagnaGiovanni ZambrottaMario BossiStefania CitterioBarbara CrescenziFrancesca FanelliValeria CassinaRoberta CortiDomenico SalernoLuca NardoClizia ChinelloFrancesco MantegazzaCristina MecucciFulvio MagniGuido CavalettiPer BruheimDelphine ReaSteen LarsenCarlo Gambacorti-PasseriniRocco PiazzaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Diletta Fontana Mario Mauri Rossella Renso Mattia Docci Ilaria Crespiatico Lisa M. Røst Mi Jang Antonio Niro Deborah D’Aliberti Luca Massimino Mayla Bertagna Giovanni Zambrotta Mario Bossi Stefania Citterio Barbara Crescenzi Francesca Fanelli Valeria Cassina Roberta Corti Domenico Salerno Luca Nardo Clizia Chinello Francesco Mantegazza Cristina Mecucci Fulvio Magni Guido Cavaletti Per Bruheim Delphine Rea Steen Larsen Carlo Gambacorti-Passerini Rocco Piazza ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine |
| description |
ETNK1 mutations are recurrent in leukemia but how they contribute to oncogenesis is still unclear. Here, the authors show that ETNK1 mutations increase mitochondrial activity, ROS and H2AX levels and that these effects can be rescued upon phosphoethanolamine supplementation. |
| format |
article |
| author |
Diletta Fontana Mario Mauri Rossella Renso Mattia Docci Ilaria Crespiatico Lisa M. Røst Mi Jang Antonio Niro Deborah D’Aliberti Luca Massimino Mayla Bertagna Giovanni Zambrotta Mario Bossi Stefania Citterio Barbara Crescenzi Francesca Fanelli Valeria Cassina Roberta Corti Domenico Salerno Luca Nardo Clizia Chinello Francesco Mantegazza Cristina Mecucci Fulvio Magni Guido Cavaletti Per Bruheim Delphine Rea Steen Larsen Carlo Gambacorti-Passerini Rocco Piazza |
| author_facet |
Diletta Fontana Mario Mauri Rossella Renso Mattia Docci Ilaria Crespiatico Lisa M. Røst Mi Jang Antonio Niro Deborah D’Aliberti Luca Massimino Mayla Bertagna Giovanni Zambrotta Mario Bossi Stefania Citterio Barbara Crescenzi Francesca Fanelli Valeria Cassina Roberta Corti Domenico Salerno Luca Nardo Clizia Chinello Francesco Mantegazza Cristina Mecucci Fulvio Magni Guido Cavaletti Per Bruheim Delphine Rea Steen Larsen Carlo Gambacorti-Passerini Rocco Piazza |
| author_sort |
Diletta Fontana |
| title |
ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine |
| title_short |
ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine |
| title_full |
ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine |
| title_fullStr |
ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine |
| title_full_unstemmed |
ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine |
| title_sort |
etnk1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/001bd3e4deb94183af19e38c9741b285 |
| work_keys_str_mv |
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