The therapeutic relationship and adherence to antipsychotic medication in schizophrenia.

<h4>Objective</h4>Previous research has shown that a better therapeutic relationship (TR) predicts more positive attitudes towards antipsychotic medication, but did not address whether it is also linked with actual adherence. This study investigated whether the TR is associated with adhe...

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Autores principales:	Rosemarie McCabe, Jens Bullenkamp, Lars Hansson, Christoph Lauber, Rafael Martinez-Leal, Wulf Rössler, Hans Joachim Salize, Bengt Svensson, Francisco Torres-Gonzalez, Rob van den Brink, Durk Wiersma, Stefan Priebe
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0025a5471c3e446ab07222f42496e922
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spelling	oai:doaj.org-article:0025a5471c3e446ab07222f42496e9222021-11-18T07:20:26ZThe therapeutic relationship and adherence to antipsychotic medication in schizophrenia.1932-620310.1371/journal.pone.0036080https://doaj.org/article/0025a5471c3e446ab07222f42496e9222012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22558336/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Previous research has shown that a better therapeutic relationship (TR) predicts more positive attitudes towards antipsychotic medication, but did not address whether it is also linked with actual adherence. This study investigated whether the TR is associated with adherence to antipsychotics in patients with schizophrenia.<h4>Methods</h4>134 clinicians and 507 of their patients with schizophrenia or a related psychotic disorder participated in a European multi-centre study. A logistic regression model examined how the TR as rated by patients and by clinicians is associated with medication adherence, adjusting for clinician clustering and symptom severity.<h4>Results</h4>Patient and clinician ratings of the TR were weakly inter-correlated (r(s) = 0.13, p = 0.004), but each was independently linked with better adherence. After adjusting for patient rated TR and symptom severity, each unit increase in clinician rated TR was associated with an increase of the odds ratio of good compliance by 65.9% (95% CI: 34.6% to 104.5%). After adjusting for clinician rated TR and symptom severity, for each unit increase in patient rated TR the odds ratio of good compliance was increased by 20.8% (95% CI: 4.4% to 39.8%).<h4>Conclusions</h4>A better TR is associated with better adherence to medication among patients with schizophrenia. Patients' and clinicians' perspectives of the TR are both important, but may reflect distinct aspects.Rosemarie McCabeJens BullenkampLars HanssonChristoph LauberRafael Martinez-LealWulf RösslerHans Joachim SalizeBengt SvenssonFrancisco Torres-GonzalezRob van den BrinkDurk WiersmaStefan PriebePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e36080 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rosemarie McCabe Jens Bullenkamp Lars Hansson Christoph Lauber Rafael Martinez-Leal Wulf Rössler Hans Joachim Salize Bengt Svensson Francisco Torres-Gonzalez Rob van den Brink Durk Wiersma Stefan Priebe The therapeutic relationship and adherence to antipsychotic medication in schizophrenia.
description	<h4>Objective</h4>Previous research has shown that a better therapeutic relationship (TR) predicts more positive attitudes towards antipsychotic medication, but did not address whether it is also linked with actual adherence. This study investigated whether the TR is associated with adherence to antipsychotics in patients with schizophrenia.<h4>Methods</h4>134 clinicians and 507 of their patients with schizophrenia or a related psychotic disorder participated in a European multi-centre study. A logistic regression model examined how the TR as rated by patients and by clinicians is associated with medication adherence, adjusting for clinician clustering and symptom severity.<h4>Results</h4>Patient and clinician ratings of the TR were weakly inter-correlated (r(s) = 0.13, p = 0.004), but each was independently linked with better adherence. After adjusting for patient rated TR and symptom severity, each unit increase in clinician rated TR was associated with an increase of the odds ratio of good compliance by 65.9% (95% CI: 34.6% to 104.5%). After adjusting for clinician rated TR and symptom severity, for each unit increase in patient rated TR the odds ratio of good compliance was increased by 20.8% (95% CI: 4.4% to 39.8%).<h4>Conclusions</h4>A better TR is associated with better adherence to medication among patients with schizophrenia. Patients' and clinicians' perspectives of the TR are both important, but may reflect distinct aspects.
format	article
author	Rosemarie McCabe Jens Bullenkamp Lars Hansson Christoph Lauber Rafael Martinez-Leal Wulf Rössler Hans Joachim Salize Bengt Svensson Francisco Torres-Gonzalez Rob van den Brink Durk Wiersma Stefan Priebe
author_facet	Rosemarie McCabe Jens Bullenkamp Lars Hansson Christoph Lauber Rafael Martinez-Leal Wulf Rössler Hans Joachim Salize Bengt Svensson Francisco Torres-Gonzalez Rob van den Brink Durk Wiersma Stefan Priebe
author_sort	Rosemarie McCabe
title	The therapeutic relationship and adherence to antipsychotic medication in schizophrenia.
title_short	The therapeutic relationship and adherence to antipsychotic medication in schizophrenia.
title_full	The therapeutic relationship and adherence to antipsychotic medication in schizophrenia.
title_fullStr	The therapeutic relationship and adherence to antipsychotic medication in schizophrenia.
title_full_unstemmed	The therapeutic relationship and adherence to antipsychotic medication in schizophrenia.
title_sort	therapeutic relationship and adherence to antipsychotic medication in schizophrenia.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0025a5471c3e446ab07222f42496e922
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The therapeutic relationship and adherence to antipsychotic medication in schizophrenia.

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