IN VITRO INTERACTION OF INFLUENZA VIRUS A(H1N1)pdm09 WITH MONOCYTIC MACROPHAGES: INDIVIDUAL RESPONSES OF TLR7 AND RIG1 RECEPTOR GENES

In vitro differentiation of donor blood monocytes to macrophages (Mph) following GM-CSF treatment was accompanied by a significant increase in the levels of gene transcription signaling receptors TLR7 or RIG1. The levels of intracellular viral RNA (M1 gene) in Mph remained high upon infection by inf...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	T. M. Sokolova, V. V. Poloskov, A. N. Shuvalov, I. A. Rudneva, T. A. Timofeeva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	influenza virus a (h1n1)pdm09 monocytic macrophages gene expression tlr7 rig1 receptors Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/0025d1b595334a7f9b64bd68e144ae96
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0025d1b595334a7f9b64bd68e144ae96
record_format	dspace
spelling	oai:doaj.org-article:0025d1b595334a7f9b64bd68e144ae962021-11-18T08:03:46ZIN VITRO INTERACTION OF INFLUENZA VIRUS A(H1N1)pdm09 WITH MONOCYTIC MACROPHAGES: INDIVIDUAL RESPONSES OF TLR7 AND RIG1 RECEPTOR GENES1563-06252313-741X10.15789/1563-0625-2017-6-721-730https://doaj.org/article/0025d1b595334a7f9b64bd68e144ae962017-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1395https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XIn vitro differentiation of donor blood monocytes to macrophages (Mph) following GM-CSF treatment was accompanied by a significant increase in the levels of gene transcription signaling receptors TLR7 or RIG1. The levels of intracellular viral RNA (M1 gene) in Mph remained high upon infection by influenza virus A H1N1pdm (Moscow 2009) for 24-96 hours. The innate immunity reactions caused by influenza virus show individual features: they are decreased in Mph from donor 1 which had initially high level of endosomal TLR7 gene activity, and it increased by influenza virus in MPh from donor 2 who had a very low level of TLR7 gene expression. The influenza H1N1pdm virus weakly stimulated expression of gene RIG1 and production of inflammatory cytokines in Mf in donor 1. The differences may be connected with individual sensitivity of the donors to influenza infection.T. M. SokolovaV. V. PoloskovA. N. ShuvalovI. A. RudnevaT. A. TimofeevaSPb RAACIarticleinfluenza virus a (h1n1)pdm09monocytic macrophagesgene expression tlr7rig1 receptorsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 6, Pp 721-730 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	influenza virus a (h1n1)pdm09 monocytic macrophages gene expression tlr7 rig1 receptors Immunologic diseases. Allergy RC581-607
spellingShingle	influenza virus a (h1n1)pdm09 monocytic macrophages gene expression tlr7 rig1 receptors Immunologic diseases. Allergy RC581-607 T. M. Sokolova V. V. Poloskov A. N. Shuvalov I. A. Rudneva T. A. Timofeeva IN VITRO INTERACTION OF INFLUENZA VIRUS A(H1N1)pdm09 WITH MONOCYTIC MACROPHAGES: INDIVIDUAL RESPONSES OF TLR7 AND RIG1 RECEPTOR GENES
description	In vitro differentiation of donor blood monocytes to macrophages (Mph) following GM-CSF treatment was accompanied by a significant increase in the levels of gene transcription signaling receptors TLR7 or RIG1. The levels of intracellular viral RNA (M1 gene) in Mph remained high upon infection by influenza virus A H1N1pdm (Moscow 2009) for 24-96 hours. The innate immunity reactions caused by influenza virus show individual features: they are decreased in Mph from donor 1 which had initially high level of endosomal TLR7 gene activity, and it increased by influenza virus in MPh from donor 2 who had a very low level of TLR7 gene expression. The influenza H1N1pdm virus weakly stimulated expression of gene RIG1 and production of inflammatory cytokines in Mf in donor 1. The differences may be connected with individual sensitivity of the donors to influenza infection.
format	article
author	T. M. Sokolova V. V. Poloskov A. N. Shuvalov I. A. Rudneva T. A. Timofeeva
author_facet	T. M. Sokolova V. V. Poloskov A. N. Shuvalov I. A. Rudneva T. A. Timofeeva
author_sort	T. M. Sokolova
title	IN VITRO INTERACTION OF INFLUENZA VIRUS A(H1N1)pdm09 WITH MONOCYTIC MACROPHAGES: INDIVIDUAL RESPONSES OF TLR7 AND RIG1 RECEPTOR GENES
title_short	IN VITRO INTERACTION OF INFLUENZA VIRUS A(H1N1)pdm09 WITH MONOCYTIC MACROPHAGES: INDIVIDUAL RESPONSES OF TLR7 AND RIG1 RECEPTOR GENES
title_full	IN VITRO INTERACTION OF INFLUENZA VIRUS A(H1N1)pdm09 WITH MONOCYTIC MACROPHAGES: INDIVIDUAL RESPONSES OF TLR7 AND RIG1 RECEPTOR GENES
title_fullStr	IN VITRO INTERACTION OF INFLUENZA VIRUS A(H1N1)pdm09 WITH MONOCYTIC MACROPHAGES: INDIVIDUAL RESPONSES OF TLR7 AND RIG1 RECEPTOR GENES
title_full_unstemmed	IN VITRO INTERACTION OF INFLUENZA VIRUS A(H1N1)pdm09 WITH MONOCYTIC MACROPHAGES: INDIVIDUAL RESPONSES OF TLR7 AND RIG1 RECEPTOR GENES
title_sort	in vitro interaction of influenza virus a(h1n1)pdm09 with monocytic macrophages: individual responses of tlr7 and rig1 receptor genes
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/0025d1b595334a7f9b64bd68e144ae96
work_keys_str_mv	AT tmsokolova invitrointeractionofinfluenzavirusah1n1pdm09withmonocyticmacrophagesindividualresponsesoftlr7andrig1receptorgenes AT vvpoloskov invitrointeractionofinfluenzavirusah1n1pdm09withmonocyticmacrophagesindividualresponsesoftlr7andrig1receptorgenes AT anshuvalov invitrointeractionofinfluenzavirusah1n1pdm09withmonocyticmacrophagesindividualresponsesoftlr7andrig1receptorgenes AT iarudneva invitrointeractionofinfluenzavirusah1n1pdm09withmonocyticmacrophagesindividualresponsesoftlr7andrig1receptorgenes AT tatimofeeva invitrointeractionofinfluenzavirusah1n1pdm09withmonocyticmacrophagesindividualresponsesoftlr7andrig1receptorgenes
_version_	1718422393088638976

IN VITRO INTERACTION OF INFLUENZA VIRUS A(H1N1)pdm09 WITH MONOCYTIC MACROPHAGES: INDIVIDUAL RESPONSES OF TLR7 AND RIG1 RECEPTOR GENES

Ejemplares similares