The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals

Abstract Vitamin D deficiency affects approximately 80% of individuals in some countries and has been linked with gut dysbiosis and inflammation. While the benefits of vitamin D supplementation on the gut microbiota have been studied in patients with chronic diseases, its effects on the microbiota o...

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Autores principales:	Parul Singh, Arun Rawat, Mariam Alwakeel, Elham Sharif, Souhaila Al Khodor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0026d1c73ff04d4fb22c981fe969b4dc
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spelling	oai:doaj.org-article:0026d1c73ff04d4fb22c981fe969b4dc2021-12-02T15:11:53ZThe potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals10.1038/s41598-020-77806-42045-2322https://doaj.org/article/0026d1c73ff04d4fb22c981fe969b4dc2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77806-4https://doaj.org/toc/2045-2322Abstract Vitamin D deficiency affects approximately 80% of individuals in some countries and has been linked with gut dysbiosis and inflammation. While the benefits of vitamin D supplementation on the gut microbiota have been studied in patients with chronic diseases, its effects on the microbiota of otherwise healthy individuals is unclear. Moreover, whether effects on the microbiota can explain some of the marked inter-individual variation in responsiveness to vitamin D supplementation is unknown. Here, we administered vitamin D to 80 otherwise healthy vitamin D-deficient women, measuring serum 25(OH) D levels in blood and characterizing their gut microbiota pre- and post- supplementation using 16S rRNA gene sequencing. Vitamin D supplementation significantly increased gut microbial diversity. Specifically, the Bacteroidetes to Firmicutes ratio increased, along with the abundance of the health-promoting probiotic taxa Akkermansia and Bifidobacterium. Significant variations in the two-dominant genera, Bacteroides and Prevotella, indicated a variation in enterotypes following supplementation. Comparing supplementation responders and non-responders we found more pronounced changes in abundance of major phyla in responders, and a significant decrease in Bacteroides acidifaciens in non-responders. Altogether, our study highlights the positive impact of vitamin D supplementation on the gut microbiota and the potential for the microbial gut signature to affect vitamin D response.Parul SinghArun RawatMariam AlwakeelElham SharifSouhaila Al KhodorNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Parul Singh Arun Rawat Mariam Alwakeel Elham Sharif Souhaila Al Khodor The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals
description	Abstract Vitamin D deficiency affects approximately 80% of individuals in some countries and has been linked with gut dysbiosis and inflammation. While the benefits of vitamin D supplementation on the gut microbiota have been studied in patients with chronic diseases, its effects on the microbiota of otherwise healthy individuals is unclear. Moreover, whether effects on the microbiota can explain some of the marked inter-individual variation in responsiveness to vitamin D supplementation is unknown. Here, we administered vitamin D to 80 otherwise healthy vitamin D-deficient women, measuring serum 25(OH) D levels in blood and characterizing their gut microbiota pre- and post- supplementation using 16S rRNA gene sequencing. Vitamin D supplementation significantly increased gut microbial diversity. Specifically, the Bacteroidetes to Firmicutes ratio increased, along with the abundance of the health-promoting probiotic taxa Akkermansia and Bifidobacterium. Significant variations in the two-dominant genera, Bacteroides and Prevotella, indicated a variation in enterotypes following supplementation. Comparing supplementation responders and non-responders we found more pronounced changes in abundance of major phyla in responders, and a significant decrease in Bacteroides acidifaciens in non-responders. Altogether, our study highlights the positive impact of vitamin D supplementation on the gut microbiota and the potential for the microbial gut signature to affect vitamin D response.
format	article
author	Parul Singh Arun Rawat Mariam Alwakeel Elham Sharif Souhaila Al Khodor
author_facet	Parul Singh Arun Rawat Mariam Alwakeel Elham Sharif Souhaila Al Khodor
author_sort	Parul Singh
title	The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals
title_short	The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals
title_full	The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals
title_fullStr	The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals
title_full_unstemmed	The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals
title_sort	potential role of vitamin d supplementation as a gut microbiota modifier in healthy individuals
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0026d1c73ff04d4fb22c981fe969b4dc
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The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals

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