Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells.

<h4>Background</h4>Gastric cancer is one of the most common cancers in the world. The "economically developed countries" life style, including diet, constitutes a risk factor favoring this cancer. Diet modulation may lower digestive cancer incidence. Among promising food compon...

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Autores principales:	Fabien J Cousin, Sandrine Jouan-Lanhouet, Marie-Thérèse Dimanche-Boitrel, Laurent Corcos, Gwénaël Jan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/002793903bf3482ba8c3127f97d1d85d
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spelling	oai:doaj.org-article:002793903bf3482ba8c3127f97d1d85d2021-11-18T07:24:45ZMilk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells.1932-620310.1371/journal.pone.0031892https://doaj.org/article/002793903bf3482ba8c3127f97d1d85d2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22442660/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Gastric cancer is one of the most common cancers in the world. The "economically developed countries" life style, including diet, constitutes a risk factor favoring this cancer. Diet modulation may lower digestive cancer incidence. Among promising food components, dairy propionibacteria were shown to trigger apoptosis of human colon cancer cells, via the release of short-chain fatty acids acetate and propionate.<h4>Methodology/principal findings</h4>A fermented milk, exclusively fermented by P. freudenreichii, was recently designed. In this work, the pro-apoptotic potential of this new fermented milk was demonstrated on HGT-1 human gastric cancer cells. Fermented milk supernatant induced typical features of apoptosis including chromatin condensation, formation of apoptotic bodies, DNA laddering, cell cycle arrest and emergence of a subG1 population, phosphatidylserine exposure at the plasma membrane outer leaflet, reactive oxygen species accumulation, mitochondrial transmembrane potential disruption, caspase activation and cytochrome c release. Remarkably, this new fermented milk containing P. freudenreichii enhanced the cytotoxicity of camptothecin, a drug used in gastric cancer chemotherapy.<h4>Conclusions/significance</h4>Such new probiotic fermented milk may thus be useful as part of a preventive diet designed to prevent gastric cancer and/or as a food supplement to potentiate cancer therapeutic treatments.Fabien J CousinSandrine Jouan-LanhouetMarie-Thérèse Dimanche-BoitrelLaurent CorcosGwénaël JanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e31892 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fabien J Cousin Sandrine Jouan-Lanhouet Marie-Thérèse Dimanche-Boitrel Laurent Corcos Gwénaël Jan Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells.
description	<h4>Background</h4>Gastric cancer is one of the most common cancers in the world. The "economically developed countries" life style, including diet, constitutes a risk factor favoring this cancer. Diet modulation may lower digestive cancer incidence. Among promising food components, dairy propionibacteria were shown to trigger apoptosis of human colon cancer cells, via the release of short-chain fatty acids acetate and propionate.<h4>Methodology/principal findings</h4>A fermented milk, exclusively fermented by P. freudenreichii, was recently designed. In this work, the pro-apoptotic potential of this new fermented milk was demonstrated on HGT-1 human gastric cancer cells. Fermented milk supernatant induced typical features of apoptosis including chromatin condensation, formation of apoptotic bodies, DNA laddering, cell cycle arrest and emergence of a subG1 population, phosphatidylserine exposure at the plasma membrane outer leaflet, reactive oxygen species accumulation, mitochondrial transmembrane potential disruption, caspase activation and cytochrome c release. Remarkably, this new fermented milk containing P. freudenreichii enhanced the cytotoxicity of camptothecin, a drug used in gastric cancer chemotherapy.<h4>Conclusions/significance</h4>Such new probiotic fermented milk may thus be useful as part of a preventive diet designed to prevent gastric cancer and/or as a food supplement to potentiate cancer therapeutic treatments.
format	article
author	Fabien J Cousin Sandrine Jouan-Lanhouet Marie-Thérèse Dimanche-Boitrel Laurent Corcos Gwénaël Jan
author_facet	Fabien J Cousin Sandrine Jouan-Lanhouet Marie-Thérèse Dimanche-Boitrel Laurent Corcos Gwénaël Jan
author_sort	Fabien J Cousin
title	Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells.
title_short	Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells.
title_full	Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells.
title_fullStr	Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells.
title_full_unstemmed	Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells.
title_sort	milk fermented by propionibacterium freudenreichii induces apoptosis of hgt-1 human gastric cancer cells.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/002793903bf3482ba8c3127f97d1d85d
work_keys_str_mv	AT fabienjcousin milkfermentedbypropionibacteriumfreudenreichiiinducesapoptosisofhgt1humangastriccancercells AT sandrinejouanlanhouet milkfermentedbypropionibacteriumfreudenreichiiinducesapoptosisofhgt1humangastriccancercells AT marietheresedimancheboitrel milkfermentedbypropionibacteriumfreudenreichiiinducesapoptosisofhgt1humangastriccancercells AT laurentcorcos milkfermentedbypropionibacteriumfreudenreichiiinducesapoptosisofhgt1humangastriccancercells AT gwenaeljan milkfermentedbypropionibacteriumfreudenreichiiinducesapoptosisofhgt1humangastriccancercells
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Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells.

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