A Promising Role of TGF-β Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report

Colorectal cancer (CRC) is one of the most common cancer types around the world. The prognosis of patients with advanced diseases is still poor in spite of currently available therapeutic options. Regorafenib is an oral tyrosine kinase inhibitor (TKI) approved to treat refractory metastatic colorect...

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Autores principales:	Simona De Summa, Katia Danza, Brunella Pilato, Giuseppina Matera, Rossella Fasano, Angela Calabrese, Rosanna Lacalamita, Nicola Silvestris, Stefania Tommasi, Antonella Argentiero, Oronzo Brunetti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	colorectal cancer TGF-b regorafenib Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0027951ec57d405099c8f898b023de3e
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spelling	oai:doaj.org-article:0027951ec57d405099c8f898b023de3e2021-11-25T18:18:53ZA Promising Role of TGF-β Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report10.3390/medicina571112411648-91441010-660Xhttps://doaj.org/article/0027951ec57d405099c8f898b023de3e2021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1241https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144Colorectal cancer (CRC) is one of the most common cancer types around the world. The prognosis of patients with advanced diseases is still poor in spite of currently available therapeutic options. Regorafenib is an oral tyrosine kinase inhibitor (TKI) approved to treat refractory metastatic colorectal cancer (mCRC). We investigated Somatic mutations in several genes involved in immunological response and cancer progression in both long/short responder mCRC patients who underwent third-line therapy with regorafenib to identify predictive biomarkers of response using Ion Torrent PGM sequencing and bioinformatic tools. We found Somatic mutations in TGFBR1, TGFBR2, and TGFBR3 genes in primary tumor and metastases samples of long-responder patients. Furthermore, our bioinformatic results show that they were mainly enriched in immune response, cell junction, and cell adhesion in long responder patients, particularly in primary tumor and metastatic sites. These data suggest that the TGF-b pattern could be the leading actor of a prolonged response to this drug.Simona De SummaKatia DanzaBrunella PilatoGiuseppina MateraRossella FasanoAngela CalabreseRosanna LacalamitaNicola SilvestrisStefania TommasiAntonella ArgentieroOronzo BrunettiMDPI AGarticlecolorectal cancerTGF-bregorafenibMedicine (General)R5-920ENMedicina, Vol 57, Iss 1241, p 1241 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer TGF-b regorafenib Medicine (General) R5-920
spellingShingle	colorectal cancer TGF-b regorafenib Medicine (General) R5-920 Simona De Summa Katia Danza Brunella Pilato Giuseppina Matera Rossella Fasano Angela Calabrese Rosanna Lacalamita Nicola Silvestris Stefania Tommasi Antonella Argentiero Oronzo Brunetti A Promising Role of TGF-β Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report
description	Colorectal cancer (CRC) is one of the most common cancer types around the world. The prognosis of patients with advanced diseases is still poor in spite of currently available therapeutic options. Regorafenib is an oral tyrosine kinase inhibitor (TKI) approved to treat refractory metastatic colorectal cancer (mCRC). We investigated Somatic mutations in several genes involved in immunological response and cancer progression in both long/short responder mCRC patients who underwent third-line therapy with regorafenib to identify predictive biomarkers of response using Ion Torrent PGM sequencing and bioinformatic tools. We found Somatic mutations in TGFBR1, TGFBR2, and TGFBR3 genes in primary tumor and metastases samples of long-responder patients. Furthermore, our bioinformatic results show that they were mainly enriched in immune response, cell junction, and cell adhesion in long responder patients, particularly in primary tumor and metastatic sites. These data suggest that the TGF-b pattern could be the leading actor of a prolonged response to this drug.
format	article
author	Simona De Summa Katia Danza Brunella Pilato Giuseppina Matera Rossella Fasano Angela Calabrese Rosanna Lacalamita Nicola Silvestris Stefania Tommasi Antonella Argentiero Oronzo Brunetti
author_facet	Simona De Summa Katia Danza Brunella Pilato Giuseppina Matera Rossella Fasano Angela Calabrese Rosanna Lacalamita Nicola Silvestris Stefania Tommasi Antonella Argentiero Oronzo Brunetti
author_sort	Simona De Summa
title	A Promising Role of TGF-β Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report
title_short	A Promising Role of TGF-β Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report
title_full	A Promising Role of TGF-β Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report
title_fullStr	A Promising Role of TGF-β Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report
title_full_unstemmed	A Promising Role of TGF-β Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report
title_sort	promising role of tgf-β pathway in response to regorafenib in metastatic colorectal cancer: a case report
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0027951ec57d405099c8f898b023de3e
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A Promising Role of TGF-β Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report

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