The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging

One of the latest theories on ageing focuses on immune response, and considers the activation of subclinical and chronic inflammation. The study was designed to explain whether anti-inflammatory diet and lifestyle exercise affect an inflammatory profile in the Polish elderly population. Sixty indivi...

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Autores principales:	Edyta Wawrzyniak-Gramacka, Natalia Hertmanowska, Anna Tylutka, Barbara Morawin, Eryk Wacka, Marzena Gutowicz, Agnieszka Zembron-Lacny
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cytokines nutritional status physical performance C-reactive protein cell-free DNA Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/002f40ee51ff4b9b99297fad6382547e
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spelling	oai:doaj.org-article:002f40ee51ff4b9b99297fad6382547e2021-11-25T18:33:15ZThe Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging10.3390/nu131136962072-6643https://doaj.org/article/002f40ee51ff4b9b99297fad6382547e2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3696https://doaj.org/toc/2072-6643One of the latest theories on ageing focuses on immune response, and considers the activation of subclinical and chronic inflammation. The study was designed to explain whether anti-inflammatory diet and lifestyle exercise affect an inflammatory profile in the Polish elderly population. Sixty individuals (80.2 ± 7.9 years) were allocated to a low-grade inflammation (LGI <i>n</i> = 33) or high-grade inflammation (HGI <i>n</i> = 27) group, based on C-reactive protein concentration (<3 or ≥3 mg/L) as a conventional marker of systemic inflammation. Diet analysis focused on vitamins D, C, E, A, β-carotene, n-3 and n-6 PUFA using single 24-h dietary recall. LGI demonstrated a lower n-6/n-3 PUFA but higher vitamin D intake than HGI. Physical performance based on 6-min walk test (6MWT) classified the elderly as physically inactive, whereby LGI demonstrated a significantly higher gait speed (1.09 ± 0.26 m/s) than HGI (0.72 ± 0.28 m/s). Circulating interleukins IL-1β, IL-6, IL-13, TNFα and cfDNA demonstrated high concentrations in the elderly with low 6MWT, confirming an impairment of physical performance by persistent systemic inflammation. These findings reveal that increased intake of anti-inflammatory diet ingredients and physical activity sustained throughout life attenuate progression of inflammaging in the elderly and indicate potential therapeutic strategies to counteract pathophysiological effects of ageing.Edyta Wawrzyniak-GramackaNatalia HertmanowskaAnna TylutkaBarbara MorawinEryk WackaMarzena GutowiczAgnieszka Zembron-LacnyMDPI AGarticlecytokinesnutritional statusphysical performanceC-reactive proteincell-free DNANutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3696, p 3696 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cytokines nutritional status physical performance C-reactive protein cell-free DNA Nutrition. Foods and food supply TX341-641
spellingShingle	cytokines nutritional status physical performance C-reactive protein cell-free DNA Nutrition. Foods and food supply TX341-641 Edyta Wawrzyniak-Gramacka Natalia Hertmanowska Anna Tylutka Barbara Morawin Eryk Wacka Marzena Gutowicz Agnieszka Zembron-Lacny The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging
description	One of the latest theories on ageing focuses on immune response, and considers the activation of subclinical and chronic inflammation. The study was designed to explain whether anti-inflammatory diet and lifestyle exercise affect an inflammatory profile in the Polish elderly population. Sixty individuals (80.2 ± 7.9 years) were allocated to a low-grade inflammation (LGI <i>n</i> = 33) or high-grade inflammation (HGI <i>n</i> = 27) group, based on C-reactive protein concentration (<3 or ≥3 mg/L) as a conventional marker of systemic inflammation. Diet analysis focused on vitamins D, C, E, A, β-carotene, n-3 and n-6 PUFA using single 24-h dietary recall. LGI demonstrated a lower n-6/n-3 PUFA but higher vitamin D intake than HGI. Physical performance based on 6-min walk test (6MWT) classified the elderly as physically inactive, whereby LGI demonstrated a significantly higher gait speed (1.09 ± 0.26 m/s) than HGI (0.72 ± 0.28 m/s). Circulating interleukins IL-1β, IL-6, IL-13, TNFα and cfDNA demonstrated high concentrations in the elderly with low 6MWT, confirming an impairment of physical performance by persistent systemic inflammation. These findings reveal that increased intake of anti-inflammatory diet ingredients and physical activity sustained throughout life attenuate progression of inflammaging in the elderly and indicate potential therapeutic strategies to counteract pathophysiological effects of ageing.
format	article
author	Edyta Wawrzyniak-Gramacka Natalia Hertmanowska Anna Tylutka Barbara Morawin Eryk Wacka Marzena Gutowicz Agnieszka Zembron-Lacny
author_facet	Edyta Wawrzyniak-Gramacka Natalia Hertmanowska Anna Tylutka Barbara Morawin Eryk Wacka Marzena Gutowicz Agnieszka Zembron-Lacny
author_sort	Edyta Wawrzyniak-Gramacka
title	The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging
title_short	The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging
title_full	The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging
title_fullStr	The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging
title_full_unstemmed	The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging
title_sort	association of anti-inflammatory diet ingredients and lifestyle exercise with inflammaging
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/002f40ee51ff4b9b99297fad6382547e
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The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging

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