Effects of formulation types on pharmacodynamics of warfarin in patients with cerebral infarction and dysphagia

Young-Ji Kim,1,2 Jong-Woo Jeong,1 Youngshin Song,3 Tae-Sung Koo1 1Graduate School of New Drug Discovey and Development, Chungnam National University, Daejeon 305-764, Republic of Korea; 2Chungnam National University Hospital, Daejeon 305-764, Republic of Korea; 3Department of Nursing, College of Nur...

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Autores principales:	Kim YJ, Jeong JW, Song Y, Koo TS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Cerebral infarction dysphagia formulation pharmacodynamics warfarin Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/002ffbd727cf4fb1919e9cd5eb4a27c8
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spelling	oai:doaj.org-article:002ffbd727cf4fb1919e9cd5eb4a27c82021-12-02T06:21:48ZEffects of formulation types on pharmacodynamics of warfarin in patients with cerebral infarction and dysphagia1179-1438https://doaj.org/article/002ffbd727cf4fb1919e9cd5eb4a27c82019-03-01T00:00:00Zhttps://www.dovepress.com/effects-of-formulation-types-on-pharmacodynamics-of-warfarin-in-patien-peer-reviewed-article-CPAAhttps://doaj.org/toc/1179-1438Young-Ji Kim,1,2 Jong-Woo Jeong,1 Youngshin Song,3 Tae-Sung Koo1 1Graduate School of New Drug Discovey and Development, Chungnam National University, Daejeon 305-764, Republic of Korea; 2Chungnam National University Hospital, Daejeon 305-764, Republic of Korea; 3Department of Nursing, College of Nursing, Chungnam National University, Daejeon 305-764, Republic of Korea Purpose: The purpose of this study was to investigate the effects of the type of formulation on the efficacy of warfarin. Materials and methods: The electronic medical records of patients with cerebral infarction, who were administered tablet or powder formulations of warfarin from 2013–2015, were retrospectively analyzed. Clinical data, changes in the international normalized ratio (INR), the warfarin dose, and the time to reach the plasma warfarin concentration that could induce an adverse effect, such as bleeding, were evaluated. Coefficients of variation of INR and of the warfarin dose, as well as the warfarin sensitivity index (WSI), were used to evaluate the INR stability. Statistical analysis of the data was performed using a independent t-test. Additionally, survival analysis was performed. Results: The data showed that 57 and 137 patients were administered warfarin as powder and tablet formulations, respectively. We noted that INR, WSI, and INR/dose × body weight differed significantly between the two groups of patients. The median survival times to reach the plasma warfarin concentration that could induce adverse effects were 3.6 and 4.2 days of treatment with the powder and tablet formulations, respectively. The efficacy of warfarin was higher when the drug was administered as a powder than when it was administered as a tablet. Conclusion: The findings of this study indicate that INR should be carefully monitored in the first 4 days of warfarin administration as a powder formulation. Keywords: warfarin, pharmacodynamic, dysphagia, survival analysisKim YJJeong JWSong YKoo TSDove Medical PressarticleCerebral infarctiondysphagiaformulationpharmacodynamicswarfarinTherapeutics. PharmacologyRM1-950ENClinical Pharmacology: Advances and Applications, Vol Volume 11, Pp 51-56 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cerebral infarction dysphagia formulation pharmacodynamics warfarin Therapeutics. Pharmacology RM1-950
spellingShingle	Cerebral infarction dysphagia formulation pharmacodynamics warfarin Therapeutics. Pharmacology RM1-950 Kim YJ Jeong JW Song Y Koo TS Effects of formulation types on pharmacodynamics of warfarin in patients with cerebral infarction and dysphagia
description	Young-Ji Kim,1,2 Jong-Woo Jeong,1 Youngshin Song,3 Tae-Sung Koo1 1Graduate School of New Drug Discovey and Development, Chungnam National University, Daejeon 305-764, Republic of Korea; 2Chungnam National University Hospital, Daejeon 305-764, Republic of Korea; 3Department of Nursing, College of Nursing, Chungnam National University, Daejeon 305-764, Republic of Korea Purpose: The purpose of this study was to investigate the effects of the type of formulation on the efficacy of warfarin. Materials and methods: The electronic medical records of patients with cerebral infarction, who were administered tablet or powder formulations of warfarin from 2013–2015, were retrospectively analyzed. Clinical data, changes in the international normalized ratio (INR), the warfarin dose, and the time to reach the plasma warfarin concentration that could induce an adverse effect, such as bleeding, were evaluated. Coefficients of variation of INR and of the warfarin dose, as well as the warfarin sensitivity index (WSI), were used to evaluate the INR stability. Statistical analysis of the data was performed using a independent t-test. Additionally, survival analysis was performed. Results: The data showed that 57 and 137 patients were administered warfarin as powder and tablet formulations, respectively. We noted that INR, WSI, and INR/dose × body weight differed significantly between the two groups of patients. The median survival times to reach the plasma warfarin concentration that could induce adverse effects were 3.6 and 4.2 days of treatment with the powder and tablet formulations, respectively. The efficacy of warfarin was higher when the drug was administered as a powder than when it was administered as a tablet. Conclusion: The findings of this study indicate that INR should be carefully monitored in the first 4 days of warfarin administration as a powder formulation. Keywords: warfarin, pharmacodynamic, dysphagia, survival analysis
format	article
author	Kim YJ Jeong JW Song Y Koo TS
author_facet	Kim YJ Jeong JW Song Y Koo TS
author_sort	Kim YJ
title	Effects of formulation types on pharmacodynamics of warfarin in patients with cerebral infarction and dysphagia
title_short	Effects of formulation types on pharmacodynamics of warfarin in patients with cerebral infarction and dysphagia
title_full	Effects of formulation types on pharmacodynamics of warfarin in patients with cerebral infarction and dysphagia
title_fullStr	Effects of formulation types on pharmacodynamics of warfarin in patients with cerebral infarction and dysphagia
title_full_unstemmed	Effects of formulation types on pharmacodynamics of warfarin in patients with cerebral infarction and dysphagia
title_sort	effects of formulation types on pharmacodynamics of warfarin in patients with cerebral infarction and dysphagia
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/002ffbd727cf4fb1919e9cd5eb4a27c8
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Effects of formulation types on pharmacodynamics of warfarin in patients with cerebral infarction and dysphagia

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