Neural circuitry governing anxious individuals’ mis-allocation of working memory to threat

Abstract Dispositional anxiety is a trait-like phenotype that confers increased risk for a range of debilitating neuropsychiatric disorders. Like many patients with anxiety disorders, individuals with elevated levels of dispositional anxiety are prone to intrusive and distressing thoughts in the abs...

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Autores principales:	Daniel M. Stout, Alexander J. Shackman, Walker S. Pedersen, Tara A. Miskovich, Christine L. Larson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/003067d41a674f688673f8ff28fdaf38
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spelling	oai:doaj.org-article:003067d41a674f688673f8ff28fdaf382021-12-02T15:05:19ZNeural circuitry governing anxious individuals’ mis-allocation of working memory to threat10.1038/s41598-017-08443-72045-2322https://doaj.org/article/003067d41a674f688673f8ff28fdaf382017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08443-7https://doaj.org/toc/2045-2322Abstract Dispositional anxiety is a trait-like phenotype that confers increased risk for a range of debilitating neuropsychiatric disorders. Like many patients with anxiety disorders, individuals with elevated levels of dispositional anxiety are prone to intrusive and distressing thoughts in the absence of immediate threat. Recent electrophysiological research suggests that these symptoms are rooted in the mis-allocation of working memory (WM) resources to threat-related information. Here, functional MRI was used to identify the network of brain regions that support WM for faces and to quantify the allocation of neural resources to threat-related distracters in 81 young adults. Results revealed widespread evidence of mis-allocation. This was evident in both face-selective regions of the fusiform cortex and domain-general regions of the prefrontal and parietal cortices. This bias was exaggerated among individuals with a more anxious disposition. Mediation analyses provided compelling evidence that anxious individuals’ tendency to mis-allocate WM resources to threat-related distracters is statistically explained by heightened amygdala reactivity. Collectively, these results provide a neurocognitive framework for understanding the pathways linking anxious phenotypes to the development of internalizing psychopathology and set the stage for developing improved intervention strategies.Daniel M. StoutAlexander J. ShackmanWalker S. PedersenTara A. MiskovichChristine L. LarsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel M. Stout Alexander J. Shackman Walker S. Pedersen Tara A. Miskovich Christine L. Larson Neural circuitry governing anxious individuals’ mis-allocation of working memory to threat
description	Abstract Dispositional anxiety is a trait-like phenotype that confers increased risk for a range of debilitating neuropsychiatric disorders. Like many patients with anxiety disorders, individuals with elevated levels of dispositional anxiety are prone to intrusive and distressing thoughts in the absence of immediate threat. Recent electrophysiological research suggests that these symptoms are rooted in the mis-allocation of working memory (WM) resources to threat-related information. Here, functional MRI was used to identify the network of brain regions that support WM for faces and to quantify the allocation of neural resources to threat-related distracters in 81 young adults. Results revealed widespread evidence of mis-allocation. This was evident in both face-selective regions of the fusiform cortex and domain-general regions of the prefrontal and parietal cortices. This bias was exaggerated among individuals with a more anxious disposition. Mediation analyses provided compelling evidence that anxious individuals’ tendency to mis-allocate WM resources to threat-related distracters is statistically explained by heightened amygdala reactivity. Collectively, these results provide a neurocognitive framework for understanding the pathways linking anxious phenotypes to the development of internalizing psychopathology and set the stage for developing improved intervention strategies.
format	article
author	Daniel M. Stout Alexander J. Shackman Walker S. Pedersen Tara A. Miskovich Christine L. Larson
author_facet	Daniel M. Stout Alexander J. Shackman Walker S. Pedersen Tara A. Miskovich Christine L. Larson
author_sort	Daniel M. Stout
title	Neural circuitry governing anxious individuals’ mis-allocation of working memory to threat
title_short	Neural circuitry governing anxious individuals’ mis-allocation of working memory to threat
title_full	Neural circuitry governing anxious individuals’ mis-allocation of working memory to threat
title_fullStr	Neural circuitry governing anxious individuals’ mis-allocation of working memory to threat
title_full_unstemmed	Neural circuitry governing anxious individuals’ mis-allocation of working memory to threat
title_sort	neural circuitry governing anxious individuals’ mis-allocation of working memory to threat
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/003067d41a674f688673f8ff28fdaf38
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Neural circuitry governing anxious individuals’ mis-allocation of working memory to threat

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