In vivo topology converts competition for cell-matrix adhesion into directional migration

Migrating cells encounter multiple signals such as extracellular matrix (ECM) and chemokinetic factors but how these integrate in vivo is unclear. Here, the authors report that overall control of cell-ECM adhesion by Sema3A and Sdf1 can be converted into directional migration by a biased ECM network...

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Autores principales:	Fernanda Bajanca, Nadège Gouignard, Charlotte Colle, Maddy Parsons, Roberto Mayor, Eric Theveneau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0030fafa1b8745ab9151ed7f3267abdf
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id	oai:doaj.org-article:0030fafa1b8745ab9151ed7f3267abdf
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spelling	oai:doaj.org-article:0030fafa1b8745ab9151ed7f3267abdf2021-12-02T15:35:27ZIn vivo topology converts competition for cell-matrix adhesion into directional migration10.1038/s41467-019-09548-52041-1723https://doaj.org/article/0030fafa1b8745ab9151ed7f3267abdf2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09548-5https://doaj.org/toc/2041-1723Migrating cells encounter multiple signals such as extracellular matrix (ECM) and chemokinetic factors but how these integrate in vivo is unclear. Here, the authors report that overall control of cell-ECM adhesion by Sema3A and Sdf1 can be converted into directional migration by a biased ECM network.Fernanda BajancaNadège GouignardCharlotte ColleMaddy ParsonsRoberto MayorEric TheveneauNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fernanda Bajanca Nadège Gouignard Charlotte Colle Maddy Parsons Roberto Mayor Eric Theveneau In vivo topology converts competition for cell-matrix adhesion into directional migration
description	Migrating cells encounter multiple signals such as extracellular matrix (ECM) and chemokinetic factors but how these integrate in vivo is unclear. Here, the authors report that overall control of cell-ECM adhesion by Sema3A and Sdf1 can be converted into directional migration by a biased ECM network.
format	article
author	Fernanda Bajanca Nadège Gouignard Charlotte Colle Maddy Parsons Roberto Mayor Eric Theveneau
author_facet	Fernanda Bajanca Nadège Gouignard Charlotte Colle Maddy Parsons Roberto Mayor Eric Theveneau
author_sort	Fernanda Bajanca
title	In vivo topology converts competition for cell-matrix adhesion into directional migration
title_short	In vivo topology converts competition for cell-matrix adhesion into directional migration
title_full	In vivo topology converts competition for cell-matrix adhesion into directional migration
title_fullStr	In vivo topology converts competition for cell-matrix adhesion into directional migration
title_full_unstemmed	In vivo topology converts competition for cell-matrix adhesion into directional migration
title_sort	in vivo topology converts competition for cell-matrix adhesion into directional migration
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0030fafa1b8745ab9151ed7f3267abdf
work_keys_str_mv	AT fernandabajanca invivotopologyconvertscompetitionforcellmatrixadhesionintodirectionalmigration AT nadegegouignard invivotopologyconvertscompetitionforcellmatrixadhesionintodirectionalmigration AT charlottecolle invivotopologyconvertscompetitionforcellmatrixadhesionintodirectionalmigration AT maddyparsons invivotopologyconvertscompetitionforcellmatrixadhesionintodirectionalmigration AT robertomayor invivotopologyconvertscompetitionforcellmatrixadhesionintodirectionalmigration AT erictheveneau invivotopologyconvertscompetitionforcellmatrixadhesionintodirectionalmigration
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In vivo topology converts competition for cell-matrix adhesion into directional migration

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