Siderophores: More than Stealing Iron

ABSTRACT Siderophores are small molecular iron chelators that are produced by microbes and whose most notable function is to sequester iron from the host and provide this essential metal nutrient to microbes. Recent studies have proposed additional, noncanonical roles for siderophores, including the...

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Autores principales:	Judith Behnsen, Manuela Raffatellu
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/0033fdf8f0eb4c90803d192927e172ee
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spelling	oai:doaj.org-article:0033fdf8f0eb4c90803d192927e172ee2021-11-15T15:50:17ZSiderophores: More than Stealing Iron10.1128/mBio.01906-162150-7511https://doaj.org/article/0033fdf8f0eb4c90803d192927e172ee2016-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01906-16https://doaj.org/toc/2150-7511ABSTRACT Siderophores are small molecular iron chelators that are produced by microbes and whose most notable function is to sequester iron from the host and provide this essential metal nutrient to microbes. Recent studies have proposed additional, noncanonical roles for siderophores, including the acquisition of noniron metals and modulation of host functions. Recently, Holden et al. (V. I. Holden, P. Breen, S. Houle, C. M. Dozois, and M. A. Bachman, mBio 7:e01397-16, 2016, http://dx.doi.org/10.1128/mBio.01397-16) showed that siderophores secreted by Klebsiella pneumoniae during lung infection induce stabilization of the transcription factor HIF-1α, increase the expression of proinflammatory cytokines in the lung, and promote dissemination of K. pneumoniae to the spleen. Thus, their study demonstrated novel roles for siderophores in vivo, beyond iron sequestration. The interaction of siderophores with host cells further promotes the pathogenicity of K. pneumoniae and is likely relevant for other pathogens that also secrete siderophores in the host.Judith BehnsenManuela RaffatelluAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 6 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Judith Behnsen Manuela Raffatellu Siderophores: More than Stealing Iron
description	ABSTRACT Siderophores are small molecular iron chelators that are produced by microbes and whose most notable function is to sequester iron from the host and provide this essential metal nutrient to microbes. Recent studies have proposed additional, noncanonical roles for siderophores, including the acquisition of noniron metals and modulation of host functions. Recently, Holden et al. (V. I. Holden, P. Breen, S. Houle, C. M. Dozois, and M. A. Bachman, mBio 7:e01397-16, 2016, http://dx.doi.org/10.1128/mBio.01397-16) showed that siderophores secreted by Klebsiella pneumoniae during lung infection induce stabilization of the transcription factor HIF-1α, increase the expression of proinflammatory cytokines in the lung, and promote dissemination of K. pneumoniae to the spleen. Thus, their study demonstrated novel roles for siderophores in vivo, beyond iron sequestration. The interaction of siderophores with host cells further promotes the pathogenicity of K. pneumoniae and is likely relevant for other pathogens that also secrete siderophores in the host.
format	article
author	Judith Behnsen Manuela Raffatellu
author_facet	Judith Behnsen Manuela Raffatellu
author_sort	Judith Behnsen
title	Siderophores: More than Stealing Iron
title_short	Siderophores: More than Stealing Iron
title_full	Siderophores: More than Stealing Iron
title_fullStr	Siderophores: More than Stealing Iron
title_full_unstemmed	Siderophores: More than Stealing Iron
title_sort	siderophores: more than stealing iron
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/0033fdf8f0eb4c90803d192927e172ee
work_keys_str_mv	AT judithbehnsen siderophoresmorethanstealingiron AT manuelaraffatellu siderophoresmorethanstealingiron
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Siderophores: More than Stealing Iron

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