SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS

Abstract. Salmon soft roe DNA influence on healthy donors blood cells secretion of early hemopoietic factors (IL-3, GM-CSF, TNFα) as well as biologically active substance influence on cytokine balance of Тh1 and Тh2 responses (IFNγ, IL-10) in vitro was studied. It is established, that DNA has modula...

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Autor principal:	L. N. Fedjanina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	salmon soft roe dna cytokines healthy donors lymphocytes lymphocytes subpopulations Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/0034f2fa925040bb90883bfd73ecec45
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spelling	oai:doaj.org-article:0034f2fa925040bb90883bfd73ecec452021-11-18T08:03:43ZSALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS1563-06252313-741X10.15789/1563-0625-2005-5-6-617-619https://doaj.org/article/0034f2fa925040bb90883bfd73ecec452014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/654https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Salmon soft roe DNA influence on healthy donors blood cells secretion of early hemopoietic factors (IL-3, GM-CSF, TNFα) as well as biologically active substance influence on cytokine balance of Тh1 and Тh2 responses (IFNγ, IL-10) in vitro was studied. It is established, that DNA has modulatory effect on secretion of all investigated cytokines - IL-3, GM-CSF, TNFα, INFγ and IL-10 by blood cells of healthy donors, increases their initially low concentration, reduces initially high and does not have essential influence at an average level of their secretion. Under action of DNA IFNγ level (stimulation index=3,3) increases more significantly than IL-10 level (stimulation index =1,9). Thus, salmon soft roe DNA possesses immunomodulatory properties.L. N. FedjaninaSPb RAACIarticlesalmon soft roe dnacytokineshealthy donorslymphocyteslymphocytes subpopulationsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 5-6, Pp 617-619 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	salmon soft roe dna cytokines healthy donors lymphocytes lymphocytes subpopulations Immunologic diseases. Allergy RC581-607
spellingShingle	salmon soft roe dna cytokines healthy donors lymphocytes lymphocytes subpopulations Immunologic diseases. Allergy RC581-607 L. N. Fedjanina SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS
description	Abstract. Salmon soft roe DNA influence on healthy donors blood cells secretion of early hemopoietic factors (IL-3, GM-CSF, TNFα) as well as biologically active substance influence on cytokine balance of Тh1 and Тh2 responses (IFNγ, IL-10) in vitro was studied. It is established, that DNA has modulatory effect on secretion of all investigated cytokines - IL-3, GM-CSF, TNFα, INFγ and IL-10 by blood cells of healthy donors, increases their initially low concentration, reduces initially high and does not have essential influence at an average level of their secretion. Under action of DNA IFNγ level (stimulation index=3,3) increases more significantly than IL-10 level (stimulation index =1,9). Thus, salmon soft roe DNA possesses immunomodulatory properties.
format	article
author	L. N. Fedjanina
author_facet	L. N. Fedjanina
author_sort	L. N. Fedjanina
title	SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS
title_short	SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS
title_full	SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS
title_fullStr	SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS
title_full_unstemmed	SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS
title_sort	salmon soft roe dna on blood cells secretion of cytokines in healthy donors
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/0034f2fa925040bb90883bfd73ecec45
work_keys_str_mv	AT lnfedjanina salmonsoftroednaonbloodcellssecretionofcytokinesinhealthydonors
_version_	1718422458565918720

SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS

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