The transcription factor SoxD controls neuronal guidance in the Drosophila visual system

Abstract Precise control of neurite guidance during development is essential to ensure proper formation of neuronal networks and correct function of the central nervous system (CNS). How neuronal projections find their targets to generate appropriate synapses is not entirely understood. Although tra...

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Autores principales:	Esteban G. Contreras, Tomás Palominos, Álvaro Glavic, Andrea H. Brand, Jimena Sierralta, Carlos Oliva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/00365aae3c474812b93199fc150ea8c9
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spelling	oai:doaj.org-article:00365aae3c474812b93199fc150ea8c92021-12-02T15:08:51ZThe transcription factor SoxD controls neuronal guidance in the Drosophila visual system10.1038/s41598-018-31654-52045-2322https://doaj.org/article/00365aae3c474812b93199fc150ea8c92018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-31654-5https://doaj.org/toc/2045-2322Abstract Precise control of neurite guidance during development is essential to ensure proper formation of neuronal networks and correct function of the central nervous system (CNS). How neuronal projections find their targets to generate appropriate synapses is not entirely understood. Although transcription factors are key molecules during neurogenesis, we do not know their entire function during the formation of networks in the CNS. Here, we used the Drosophila melanogaster optic lobe as a model for understanding neurite guidance during development. We assessed the function of Sox102F/SoxD, the unique Drosophila orthologue of the vertebrate SoxD family of transcription factors. SoxD is expressed in immature and mature neurons in the larval and adult lobula plate ganglia (one of the optic lobe neuropils), but is absent from glial cells, neural stem cells and progenitors of the lobula plate. SoxD RNAi knockdown in all neurons results in a reduction of the lobula plate neuropil, without affecting neuronal fate. This morphological defect is associated with an impaired optomotor response of adult flies. Moreover, knocking down SoxD only in T4/T5 neuronal types, which control motion vision, affects proper neurite guidance into the medulla and lobula. Our findings suggest that SoxD regulates neurite guidance, without affecting neuronal fate.Esteban G. ContrerasTomás PalominosÁlvaro GlavicAndrea H. BrandJimena SierraltaCarlos OlivaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Esteban G. Contreras Tomás Palominos Álvaro Glavic Andrea H. Brand Jimena Sierralta Carlos Oliva The transcription factor SoxD controls neuronal guidance in the Drosophila visual system
description	Abstract Precise control of neurite guidance during development is essential to ensure proper formation of neuronal networks and correct function of the central nervous system (CNS). How neuronal projections find their targets to generate appropriate synapses is not entirely understood. Although transcription factors are key molecules during neurogenesis, we do not know their entire function during the formation of networks in the CNS. Here, we used the Drosophila melanogaster optic lobe as a model for understanding neurite guidance during development. We assessed the function of Sox102F/SoxD, the unique Drosophila orthologue of the vertebrate SoxD family of transcription factors. SoxD is expressed in immature and mature neurons in the larval and adult lobula plate ganglia (one of the optic lobe neuropils), but is absent from glial cells, neural stem cells and progenitors of the lobula plate. SoxD RNAi knockdown in all neurons results in a reduction of the lobula plate neuropil, without affecting neuronal fate. This morphological defect is associated with an impaired optomotor response of adult flies. Moreover, knocking down SoxD only in T4/T5 neuronal types, which control motion vision, affects proper neurite guidance into the medulla and lobula. Our findings suggest that SoxD regulates neurite guidance, without affecting neuronal fate.
format	article
author	Esteban G. Contreras Tomás Palominos Álvaro Glavic Andrea H. Brand Jimena Sierralta Carlos Oliva
author_facet	Esteban G. Contreras Tomás Palominos Álvaro Glavic Andrea H. Brand Jimena Sierralta Carlos Oliva
author_sort	Esteban G. Contreras
title	The transcription factor SoxD controls neuronal guidance in the Drosophila visual system
title_short	The transcription factor SoxD controls neuronal guidance in the Drosophila visual system
title_full	The transcription factor SoxD controls neuronal guidance in the Drosophila visual system
title_fullStr	The transcription factor SoxD controls neuronal guidance in the Drosophila visual system
title_full_unstemmed	The transcription factor SoxD controls neuronal guidance in the Drosophila visual system
title_sort	transcription factor soxd controls neuronal guidance in the drosophila visual system
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/00365aae3c474812b93199fc150ea8c9
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The transcription factor SoxD controls neuronal guidance in the Drosophila visual system

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