Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis

Alteration of circadian rhythms is often observed in patients with chronic kidney disease (CKD). Here, the authors show that CKD-induced dysfunction of the circadian clock increases the expression of G protein-coupled receptor 68 in circulating monocytes and that their cardiac infiltration exacerbat...

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Autores principales:	Yuya Yoshida, Naoya Matsunaga, Takaharu Nakao, Kengo Hamamura, Hideaki Kondo, Tomomi Ide, Hiroyuki Tsutsui, Akito Tsuruta, Masayuki Kurogi, Michio Nakaya, Hitoshi Kurose, Satoru Koyanagi, Shigehiro Ohdo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/003803f8997a470c8148526aae949ed1
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spelling	oai:doaj.org-article:003803f8997a470c8148526aae949ed12021-12-02T15:54:54ZAlteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis10.1038/s41467-021-23050-x2041-1723https://doaj.org/article/003803f8997a470c8148526aae949ed12021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23050-xhttps://doaj.org/toc/2041-1723Alteration of circadian rhythms is often observed in patients with chronic kidney disease (CKD). Here, the authors show that CKD-induced dysfunction of the circadian clock increases the expression of G protein-coupled receptor 68 in circulating monocytes and that their cardiac infiltration exacerbates inflammation and fibrosis of heart.Yuya YoshidaNaoya MatsunagaTakaharu NakaoKengo HamamuraHideaki KondoTomomi IdeHiroyuki TsutsuiAkito TsurutaMasayuki KurogiMichio NakayaHitoshi KuroseSatoru KoyanagiShigehiro OhdoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuya Yoshida Naoya Matsunaga Takaharu Nakao Kengo Hamamura Hideaki Kondo Tomomi Ide Hiroyuki Tsutsui Akito Tsuruta Masayuki Kurogi Michio Nakaya Hitoshi Kurose Satoru Koyanagi Shigehiro Ohdo Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis
description	Alteration of circadian rhythms is often observed in patients with chronic kidney disease (CKD). Here, the authors show that CKD-induced dysfunction of the circadian clock increases the expression of G protein-coupled receptor 68 in circulating monocytes and that their cardiac infiltration exacerbates inflammation and fibrosis of heart.
format	article
author	Yuya Yoshida Naoya Matsunaga Takaharu Nakao Kengo Hamamura Hideaki Kondo Tomomi Ide Hiroyuki Tsutsui Akito Tsuruta Masayuki Kurogi Michio Nakaya Hitoshi Kurose Satoru Koyanagi Shigehiro Ohdo
author_facet	Yuya Yoshida Naoya Matsunaga Takaharu Nakao Kengo Hamamura Hideaki Kondo Tomomi Ide Hiroyuki Tsutsui Akito Tsuruta Masayuki Kurogi Michio Nakaya Hitoshi Kurose Satoru Koyanagi Shigehiro Ohdo
author_sort	Yuya Yoshida
title	Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis
title_short	Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis
title_full	Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis
title_fullStr	Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis
title_full_unstemmed	Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis
title_sort	alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/003803f8997a470c8148526aae949ed1
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Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis

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