Corneal dendritic cells and the subbasal nerve plexus following neurotoxic treatment with oxaliplatin or paclitaxel

Abstract Immune cell infiltration has been implicated in neurotoxic chemotherapy for cancer treatment. However, our understanding of immune processes is still incomplete and current methods of observing immune cells are time consuming or invasive. Corneal dendritic cells are potent antigen-presentin...

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Autores principales:	Jeremy Chung Bo Chiang, David Goldstein, Azadeh Tavakoli, Terry Trinh, Jacob Klisser, Craig R. Lewis, Michael Friedlander, Thomas J. Naduvilath, Kimberley Au, Susanna B. Park, Arun V. Krishnan, Maria Markoulli
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Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/00382dae9ddf41f08fab328294b408ea
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spelling	oai:doaj.org-article:00382dae9ddf41f08fab328294b408ea2021-11-28T12:19:22ZCorneal dendritic cells and the subbasal nerve plexus following neurotoxic treatment with oxaliplatin or paclitaxel10.1038/s41598-021-02439-02045-2322https://doaj.org/article/00382dae9ddf41f08fab328294b408ea2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02439-0https://doaj.org/toc/2045-2322Abstract Immune cell infiltration has been implicated in neurotoxic chemotherapy for cancer treatment. However, our understanding of immune processes is still incomplete and current methods of observing immune cells are time consuming or invasive. Corneal dendritic cells are potent antigen-presenting cells and can be imaged with in-vivo corneal confocal microscopy. Corneal dendritic cell densities and nerve parameters in patients treated with neurotoxic chemotherapy were investigated. Patients treated for cancer with oxaliplatin (n = 39) or paclitaxel (n = 48), 3 to 24 months prior to assessment were recruited along with 40 healthy controls. Immature (ImDC), mature (MDC) and total dendritic cell densities (TotalDC), and corneal nerve parameters were analyzed from in-vivo corneal confocal microscopy images. ImDC was increased in the oxaliplatin group (Median, Md = 22.7 cells/mm2) compared to healthy controls (Md = 10.1 cells/mm2, p = 0.001), but not in the paclitaxel group (Md = 10.6 cells/mm2). ImDC was also associated with higher oxaliplatin cumulative dose (r = 0.33, p = 0.04) and treatment cycles (r = 0.40, p = 0.01). There was no significant difference in MDC between the three groups (p > 0.05). Corneal nerve parameters were reduced in both oxaliplatin and paclitaxel groups compared to healthy controls (p < 0.05). There is evidence of elevation of corneal ImDC in oxaliplatin-treated patients. Further investigation is required to explore this potential link through longitudinal studies and animal or laboratory-based immunohistochemical research.Jeremy Chung Bo ChiangDavid GoldsteinAzadeh TavakoliTerry TrinhJacob KlisserCraig R. LewisMichael FriedlanderThomas J. NaduvilathKimberley AuSusanna B. ParkArun V. KrishnanMaria MarkoulliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeremy Chung Bo Chiang David Goldstein Azadeh Tavakoli Terry Trinh Jacob Klisser Craig R. Lewis Michael Friedlander Thomas J. Naduvilath Kimberley Au Susanna B. Park Arun V. Krishnan Maria Markoulli Corneal dendritic cells and the subbasal nerve plexus following neurotoxic treatment with oxaliplatin or paclitaxel
description	Abstract Immune cell infiltration has been implicated in neurotoxic chemotherapy for cancer treatment. However, our understanding of immune processes is still incomplete and current methods of observing immune cells are time consuming or invasive. Corneal dendritic cells are potent antigen-presenting cells and can be imaged with in-vivo corneal confocal microscopy. Corneal dendritic cell densities and nerve parameters in patients treated with neurotoxic chemotherapy were investigated. Patients treated for cancer with oxaliplatin (n = 39) or paclitaxel (n = 48), 3 to 24 months prior to assessment were recruited along with 40 healthy controls. Immature (ImDC), mature (MDC) and total dendritic cell densities (TotalDC), and corneal nerve parameters were analyzed from in-vivo corneal confocal microscopy images. ImDC was increased in the oxaliplatin group (Median, Md = 22.7 cells/mm2) compared to healthy controls (Md = 10.1 cells/mm2, p = 0.001), but not in the paclitaxel group (Md = 10.6 cells/mm2). ImDC was also associated with higher oxaliplatin cumulative dose (r = 0.33, p = 0.04) and treatment cycles (r = 0.40, p = 0.01). There was no significant difference in MDC between the three groups (p > 0.05). Corneal nerve parameters were reduced in both oxaliplatin and paclitaxel groups compared to healthy controls (p < 0.05). There is evidence of elevation of corneal ImDC in oxaliplatin-treated patients. Further investigation is required to explore this potential link through longitudinal studies and animal or laboratory-based immunohistochemical research.
format	article
author	Jeremy Chung Bo Chiang David Goldstein Azadeh Tavakoli Terry Trinh Jacob Klisser Craig R. Lewis Michael Friedlander Thomas J. Naduvilath Kimberley Au Susanna B. Park Arun V. Krishnan Maria Markoulli
author_facet	Jeremy Chung Bo Chiang David Goldstein Azadeh Tavakoli Terry Trinh Jacob Klisser Craig R. Lewis Michael Friedlander Thomas J. Naduvilath Kimberley Au Susanna B. Park Arun V. Krishnan Maria Markoulli
author_sort	Jeremy Chung Bo Chiang
title	Corneal dendritic cells and the subbasal nerve plexus following neurotoxic treatment with oxaliplatin or paclitaxel
title_short	Corneal dendritic cells and the subbasal nerve plexus following neurotoxic treatment with oxaliplatin or paclitaxel
title_full	Corneal dendritic cells and the subbasal nerve plexus following neurotoxic treatment with oxaliplatin or paclitaxel
title_fullStr	Corneal dendritic cells and the subbasal nerve plexus following neurotoxic treatment with oxaliplatin or paclitaxel
title_full_unstemmed	Corneal dendritic cells and the subbasal nerve plexus following neurotoxic treatment with oxaliplatin or paclitaxel
title_sort	corneal dendritic cells and the subbasal nerve plexus following neurotoxic treatment with oxaliplatin or paclitaxel
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/00382dae9ddf41f08fab328294b408ea
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Corneal dendritic cells and the subbasal nerve plexus following neurotoxic treatment with oxaliplatin or paclitaxel

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