Prevalence, beliefs and impact of drug-drug interactions between antiretroviral therapy and illicit drugs among people living with HIV in Spain.

Drug use implies important challenges related to HIV management, particularly due to an increased risk of potential interactions between antiretroviral therapy (ART) and illicit drugs (pDDIs). This study analyses the prevalence and severity of pDDIs among people living with HIV (PLHIV). It also expl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vanessa Castro-Granell, Noé Garin, Ángeles Jaén, Santiago Cenoz, María José Galindo, María José Fuster-RuizdeApodaca
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0038729e28544002bdcaf9ae7d85c95a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0038729e28544002bdcaf9ae7d85c95a
record_format	dspace
spelling	oai:doaj.org-article:0038729e28544002bdcaf9ae7d85c95a2021-12-02T20:12:36ZPrevalence, beliefs and impact of drug-drug interactions between antiretroviral therapy and illicit drugs among people living with HIV in Spain.1932-620310.1371/journal.pone.0260334https://doaj.org/article/0038729e28544002bdcaf9ae7d85c95a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260334https://doaj.org/toc/1932-6203Drug use implies important challenges related to HIV management, particularly due to an increased risk of potential interactions between antiretroviral therapy (ART) and illicit drugs (pDDIs). This study analyses the prevalence and severity of pDDIs among people living with HIV (PLHIV). It also explores their awareness of pDDIs and their beliefs about the toxicity that they may cause, as well as the impact of pDDIs on selected health variables. We conducted an on-line cross-sectional survey across 33 Spanish hospitals and NGOs to collect demographics and clinical data. pDDIs were checked against the Interaction Checker developed by Liverpool University. The sample of the present study was composed of 694 PLHIV who used illicit drugs. They represented 49.5% of the 1,401 PLHIV that participated in the survey. After excluding 38 participants due to lack of information on their ART or illicit drug use, 335 (51.1%) participants consuming drugs presented with some potentially significant pDDIs between their ART and illicit drugs, with a mean of 2.1±1.7 (1-10) pDDIs per patient. The drugs most frequently involved in pDDIs were cocaine, cannabis, MDMA and nitrates ("poppers"). The prevalence of pDDIs across ART regimens was: protease inhibitors (41.7%); integrase inhibitor-boosted regimens (32.1%), and non-nucleoside reverse transcriptase inhibitors (26.3%). An awareness of pDDIs and beliefs about their potential toxicity correlated positively with intentional non-adherence (p<0.0001). Participants with pDDIs exhibited a higher prevalence of intentional non-adherence (2.19±1.04 vs. 1.93±0.94; p = 0.001). The presence of pDDIs was not associated with poorer results in the clinical variables analysed. A significant proportion of PLHIV who use drugs experience pDDIs, thereby requiring close monitoring. pDDIs should be considered in the clinical management of HIV patients. Adequate information about pDDIs and indicators about how to manage ART when PLHIV use drugs could improve ART non-adherence.Vanessa Castro-GranellNoé GarinÁngeles JaénSantiago CenozMaría José GalindoMaría José Fuster-RuizdeApodacaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260334 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vanessa Castro-Granell Noé Garin Ángeles Jaén Santiago Cenoz María José Galindo María José Fuster-RuizdeApodaca Prevalence, beliefs and impact of drug-drug interactions between antiretroviral therapy and illicit drugs among people living with HIV in Spain.
description	Drug use implies important challenges related to HIV management, particularly due to an increased risk of potential interactions between antiretroviral therapy (ART) and illicit drugs (pDDIs). This study analyses the prevalence and severity of pDDIs among people living with HIV (PLHIV). It also explores their awareness of pDDIs and their beliefs about the toxicity that they may cause, as well as the impact of pDDIs on selected health variables. We conducted an on-line cross-sectional survey across 33 Spanish hospitals and NGOs to collect demographics and clinical data. pDDIs were checked against the Interaction Checker developed by Liverpool University. The sample of the present study was composed of 694 PLHIV who used illicit drugs. They represented 49.5% of the 1,401 PLHIV that participated in the survey. After excluding 38 participants due to lack of information on their ART or illicit drug use, 335 (51.1%) participants consuming drugs presented with some potentially significant pDDIs between their ART and illicit drugs, with a mean of 2.1±1.7 (1-10) pDDIs per patient. The drugs most frequently involved in pDDIs were cocaine, cannabis, MDMA and nitrates ("poppers"). The prevalence of pDDIs across ART regimens was: protease inhibitors (41.7%); integrase inhibitor-boosted regimens (32.1%), and non-nucleoside reverse transcriptase inhibitors (26.3%). An awareness of pDDIs and beliefs about their potential toxicity correlated positively with intentional non-adherence (p<0.0001). Participants with pDDIs exhibited a higher prevalence of intentional non-adherence (2.19±1.04 vs. 1.93±0.94; p = 0.001). The presence of pDDIs was not associated with poorer results in the clinical variables analysed. A significant proportion of PLHIV who use drugs experience pDDIs, thereby requiring close monitoring. pDDIs should be considered in the clinical management of HIV patients. Adequate information about pDDIs and indicators about how to manage ART when PLHIV use drugs could improve ART non-adherence.
format	article
author	Vanessa Castro-Granell Noé Garin Ángeles Jaén Santiago Cenoz María José Galindo María José Fuster-RuizdeApodaca
author_facet	Vanessa Castro-Granell Noé Garin Ángeles Jaén Santiago Cenoz María José Galindo María José Fuster-RuizdeApodaca
author_sort	Vanessa Castro-Granell
title	Prevalence, beliefs and impact of drug-drug interactions between antiretroviral therapy and illicit drugs among people living with HIV in Spain.
title_short	Prevalence, beliefs and impact of drug-drug interactions between antiretroviral therapy and illicit drugs among people living with HIV in Spain.
title_full	Prevalence, beliefs and impact of drug-drug interactions between antiretroviral therapy and illicit drugs among people living with HIV in Spain.
title_fullStr	Prevalence, beliefs and impact of drug-drug interactions between antiretroviral therapy and illicit drugs among people living with HIV in Spain.
title_full_unstemmed	Prevalence, beliefs and impact of drug-drug interactions between antiretroviral therapy and illicit drugs among people living with HIV in Spain.
title_sort	prevalence, beliefs and impact of drug-drug interactions between antiretroviral therapy and illicit drugs among people living with hiv in spain.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0038729e28544002bdcaf9ae7d85c95a
work_keys_str_mv	AT vanessacastrogranell prevalencebeliefsandimpactofdrugdruginteractionsbetweenantiretroviraltherapyandillicitdrugsamongpeoplelivingwithhivinspain AT noegarin prevalencebeliefsandimpactofdrugdruginteractionsbetweenantiretroviraltherapyandillicitdrugsamongpeoplelivingwithhivinspain AT angelesjaen prevalencebeliefsandimpactofdrugdruginteractionsbetweenantiretroviraltherapyandillicitdrugsamongpeoplelivingwithhivinspain AT santiagocenoz prevalencebeliefsandimpactofdrugdruginteractionsbetweenantiretroviraltherapyandillicitdrugsamongpeoplelivingwithhivinspain AT mariajosegalindo prevalencebeliefsandimpactofdrugdruginteractionsbetweenantiretroviraltherapyandillicitdrugsamongpeoplelivingwithhivinspain AT mariajosefusterruizdeapodaca prevalencebeliefsandimpactofdrugdruginteractionsbetweenantiretroviraltherapyandillicitdrugsamongpeoplelivingwithhivinspain
_version_	1718374863361540096

Prevalence, beliefs and impact of drug-drug interactions between antiretroviral therapy and illicit drugs among people living with HIV in Spain.

Ejemplares similares