Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection

Abstract Helicobacter pylori is a causative pathogen of many gastric and extra-gastric diseases. It has infected about half of the global population. There were no genome-wide association studies (GWAS) for H. pylori infection conducted in Chinese population, who carried different and relatively hom...

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Autores principales:	Dingxue Hu, Yueqi Lu, Daoming Wang, Chao Nie, Yan Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/003899e1ba9747129b0b64b3c282a0cf
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spelling	oai:doaj.org-article:003899e1ba9747129b0b64b3c282a0cf2021-12-02T15:15:58ZGlycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection10.1038/s41598-021-97790-72045-2322https://doaj.org/article/003899e1ba9747129b0b64b3c282a0cf2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97790-7https://doaj.org/toc/2045-2322Abstract Helicobacter pylori is a causative pathogen of many gastric and extra-gastric diseases. It has infected about half of the global population. There were no genome-wide association studies (GWAS) for H. pylori infection conducted in Chinese population, who carried different and relatively homogenous strain of H. pylori. In this work, we performed SNP (single nucleotide polymorphism)-based, gene-based and pathway-based genome-wide association analyses to investigate the genetic basis of host susceptibility to H. pylori infection in 480 Chinese individuals. We also profiled the composition and function of the gut microbiota between H. pylori infection cases and controls. We found several genes and pathways associated with H. pylori infection (P < 0.05), replicated one previously reported SNP rs10004195 in TLR1 gene region (P = 0.02). We also found that glycosaminoglycan biosynthesis related pathway was associated with both onset and progression of H. pylori infection. In the gut microbiome association study, we identified 2 species, 3 genera and several pathways had differential abundance between H. pylori infected cases and controls. This paper is the first GWAS for H. pylori infection in Chinese population, and we combined the genetic and microbial data to comprehensively discuss the basis of host susceptibility to H. pylori infection.Dingxue HuYueqi LuDaoming WangChao NieYan LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dingxue Hu Yueqi Lu Daoming Wang Chao Nie Yan Li Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection
description	Abstract Helicobacter pylori is a causative pathogen of many gastric and extra-gastric diseases. It has infected about half of the global population. There were no genome-wide association studies (GWAS) for H. pylori infection conducted in Chinese population, who carried different and relatively homogenous strain of H. pylori. In this work, we performed SNP (single nucleotide polymorphism)-based, gene-based and pathway-based genome-wide association analyses to investigate the genetic basis of host susceptibility to H. pylori infection in 480 Chinese individuals. We also profiled the composition and function of the gut microbiota between H. pylori infection cases and controls. We found several genes and pathways associated with H. pylori infection (P < 0.05), replicated one previously reported SNP rs10004195 in TLR1 gene region (P = 0.02). We also found that glycosaminoglycan biosynthesis related pathway was associated with both onset and progression of H. pylori infection. In the gut microbiome association study, we identified 2 species, 3 genera and several pathways had differential abundance between H. pylori infected cases and controls. This paper is the first GWAS for H. pylori infection in Chinese population, and we combined the genetic and microbial data to comprehensively discuss the basis of host susceptibility to H. pylori infection.
format	article
author	Dingxue Hu Yueqi Lu Daoming Wang Chao Nie Yan Li
author_facet	Dingxue Hu Yueqi Lu Daoming Wang Chao Nie Yan Li
author_sort	Dingxue Hu
title	Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection
title_short	Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection
title_full	Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection
title_fullStr	Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection
title_full_unstemmed	Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection
title_sort	glycosaminoglycan biosynthesis pathway in host genome is associated with helicobacter pylori infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/003899e1ba9747129b0b64b3c282a0cf
work_keys_str_mv	AT dingxuehu glycosaminoglycanbiosynthesispathwayinhostgenomeisassociatedwithhelicobacterpyloriinfection AT yueqilu glycosaminoglycanbiosynthesispathwayinhostgenomeisassociatedwithhelicobacterpyloriinfection AT daomingwang glycosaminoglycanbiosynthesispathwayinhostgenomeisassociatedwithhelicobacterpyloriinfection AT chaonie glycosaminoglycanbiosynthesispathwayinhostgenomeisassociatedwithhelicobacterpyloriinfection AT yanli glycosaminoglycanbiosynthesispathwayinhostgenomeisassociatedwithhelicobacterpyloriinfection
_version_	1718387487823364096

Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection

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