Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects

Safety issues including side effects are one of the major factors causing failure of clinical trials in drug development. Here, the authors leverage information about phenotypes associated with variation in genes encoding drug targets to predict drug-treatment-related side effects.

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Autores principales:	Phuong A. Nguyen, David A. Born, Aimee M. Deaton, Paul Nioi, Lucas D. Ward
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/003cfedb56c34cf29e4173da6041f948
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spelling	oai:doaj.org-article:003cfedb56c34cf29e4173da6041f9482021-12-02T16:58:27ZPhenotypes associated with genes encoding drug targets are predictive of clinical trial side effects10.1038/s41467-019-09407-32041-1723https://doaj.org/article/003cfedb56c34cf29e4173da6041f9482019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09407-3https://doaj.org/toc/2041-1723Safety issues including side effects are one of the major factors causing failure of clinical trials in drug development. Here, the authors leverage information about phenotypes associated with variation in genes encoding drug targets to predict drug-treatment-related side effects.Phuong A. NguyenDavid A. BornAimee M. DeatonPaul NioiLucas D. WardNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Phuong A. Nguyen David A. Born Aimee M. Deaton Paul Nioi Lucas D. Ward Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects
description	Safety issues including side effects are one of the major factors causing failure of clinical trials in drug development. Here, the authors leverage information about phenotypes associated with variation in genes encoding drug targets to predict drug-treatment-related side effects.
format	article
author	Phuong A. Nguyen David A. Born Aimee M. Deaton Paul Nioi Lucas D. Ward
author_facet	Phuong A. Nguyen David A. Born Aimee M. Deaton Paul Nioi Lucas D. Ward
author_sort	Phuong A. Nguyen
title	Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects
title_short	Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects
title_full	Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects
title_fullStr	Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects
title_full_unstemmed	Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects
title_sort	phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/003cfedb56c34cf29e4173da6041f948
work_keys_str_mv	AT phuonganguyen phenotypesassociatedwithgenesencodingdrugtargetsarepredictiveofclinicaltrialsideeffects AT davidaborn phenotypesassociatedwithgenesencodingdrugtargetsarepredictiveofclinicaltrialsideeffects AT aimeemdeaton phenotypesassociatedwithgenesencodingdrugtargetsarepredictiveofclinicaltrialsideeffects AT paulnioi phenotypesassociatedwithgenesencodingdrugtargetsarepredictiveofclinicaltrialsideeffects AT lucasdward phenotypesassociatedwithgenesencodingdrugtargetsarepredictiveofclinicaltrialsideeffects
_version_	1718382307629334528

Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects

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