Detection of selection signatures for response to Aleutian mink disease virus infection in American mink

Abstract Aleutian disease (AD) is the most significant health issue for farmed American mink. The objective of this study was to identify the genomic regions subjected to selection for response to infection with Aleutian mink disease virus (AMDV) in American mink using genotyping by sequencing (GBS)...

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Autores principales:	Karim Karimi, A. Hossain Farid, Sean Myles, Younes Miar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/00400294ef5e420eac635a83dd12c4fb
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spelling	oai:doaj.org-article:00400294ef5e420eac635a83dd12c4fb2021-12-02T14:06:18ZDetection of selection signatures for response to Aleutian mink disease virus infection in American mink10.1038/s41598-021-82522-82045-2322https://doaj.org/article/00400294ef5e420eac635a83dd12c4fb2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82522-8https://doaj.org/toc/2045-2322Abstract Aleutian disease (AD) is the most significant health issue for farmed American mink. The objective of this study was to identify the genomic regions subjected to selection for response to infection with Aleutian mink disease virus (AMDV) in American mink using genotyping by sequencing (GBS) data. A total of 225 black mink were inoculated with AMDV and genotyped using a GBS assay based on the sequencing of ApeKI-digested libraries. Five AD-characterized phenotypes were used to assign animals to pairwise groups. Signatures of selection were detected using integrated measurement of fixation index (FST) and nucleotide diversity (θπ), that were validated by haplotype-based (hap-FLK) test. The total of 99 putatively selected regions harbouring 63 genes were detected in different groups. The gene ontology revealed numerous genes related to immune response (e.g. TRAF3IP2, WDR7, SWAP70, CBFB, and GPR65), liver development (e.g. SULF2, SRSF5) and reproduction process (e.g. FBXO5, CatSperβ, CATSPER4, and IGF2R). The hapFLK test supported two strongly selected regions that contained five candidate genes related to immune response, virus–host interaction, reproduction and liver regeneration. This study provided the first map of putative selection signals of response to AMDV infection in American mink, bringing new insights into genomic regions controlling the AD phenotypes.Karim KarimiA. Hossain FaridSean MylesYounes MiarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Karim Karimi A. Hossain Farid Sean Myles Younes Miar Detection of selection signatures for response to Aleutian mink disease virus infection in American mink
description	Abstract Aleutian disease (AD) is the most significant health issue for farmed American mink. The objective of this study was to identify the genomic regions subjected to selection for response to infection with Aleutian mink disease virus (AMDV) in American mink using genotyping by sequencing (GBS) data. A total of 225 black mink were inoculated with AMDV and genotyped using a GBS assay based on the sequencing of ApeKI-digested libraries. Five AD-characterized phenotypes were used to assign animals to pairwise groups. Signatures of selection were detected using integrated measurement of fixation index (FST) and nucleotide diversity (θπ), that were validated by haplotype-based (hap-FLK) test. The total of 99 putatively selected regions harbouring 63 genes were detected in different groups. The gene ontology revealed numerous genes related to immune response (e.g. TRAF3IP2, WDR7, SWAP70, CBFB, and GPR65), liver development (e.g. SULF2, SRSF5) and reproduction process (e.g. FBXO5, CatSperβ, CATSPER4, and IGF2R). The hapFLK test supported two strongly selected regions that contained five candidate genes related to immune response, virus–host interaction, reproduction and liver regeneration. This study provided the first map of putative selection signals of response to AMDV infection in American mink, bringing new insights into genomic regions controlling the AD phenotypes.
format	article
author	Karim Karimi A. Hossain Farid Sean Myles Younes Miar
author_facet	Karim Karimi A. Hossain Farid Sean Myles Younes Miar
author_sort	Karim Karimi
title	Detection of selection signatures for response to Aleutian mink disease virus infection in American mink
title_short	Detection of selection signatures for response to Aleutian mink disease virus infection in American mink
title_full	Detection of selection signatures for response to Aleutian mink disease virus infection in American mink
title_fullStr	Detection of selection signatures for response to Aleutian mink disease virus infection in American mink
title_full_unstemmed	Detection of selection signatures for response to Aleutian mink disease virus infection in American mink
title_sort	detection of selection signatures for response to aleutian mink disease virus infection in american mink
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/00400294ef5e420eac635a83dd12c4fb
work_keys_str_mv	AT karimkarimi detectionofselectionsignaturesforresponsetoaleutianminkdiseasevirusinfectioninamericanmink AT ahossainfarid detectionofselectionsignaturesforresponsetoaleutianminkdiseasevirusinfectioninamericanmink AT seanmyles detectionofselectionsignaturesforresponsetoaleutianminkdiseasevirusinfectioninamericanmink AT younesmiar detectionofselectionsignaturesforresponsetoaleutianminkdiseasevirusinfectioninamericanmink
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Detection of selection signatures for response to Aleutian mink disease virus infection in American mink

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