The Dual Effect of the BMP9–ALK1 Pathway in Blood Vessels: An Opportunity for Cancer Therapy Improvement?

The improvement of cancer therapy efficacy, the extension of patient survival and the reduction of adverse side effects are major challenges in cancer research. Targeting blood vessels has been considered a promising strategy in cancer therapy. Since the tumor vasculature is disorganized, leaky and...

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Autores principales:	Blanca Ayuso-Íñigo, Lucía Méndez-García, Miguel Pericacho, José M. Muñoz-Félix
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tumor angiogenesis bone morphogenetic protein 9 ALK1 cancer therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/0043a30176fb45b1b342110cadd8cd4f
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spelling	oai:doaj.org-article:0043a30176fb45b1b342110cadd8cd4f2021-11-11T15:30:38ZThe Dual Effect of the BMP9–ALK1 Pathway in Blood Vessels: An Opportunity for Cancer Therapy Improvement?10.3390/cancers132154122072-6694https://doaj.org/article/0043a30176fb45b1b342110cadd8cd4f2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5412https://doaj.org/toc/2072-6694The improvement of cancer therapy efficacy, the extension of patient survival and the reduction of adverse side effects are major challenges in cancer research. Targeting blood vessels has been considered a promising strategy in cancer therapy. Since the tumor vasculature is disorganized, leaky and triggers immunosuppression and tumor hypoxia, several strategies have been studied to modify tumor vasculature for cancer therapy improvement. Anti-angiogenesis was first described as a mechanism to prevent the formation of new blood vessels and prevent the oxygen supply to tumor cells, showing numerous limitations. Vascular normalization using low doses of anti-angiogenic drugs was purposed to overcome the limitations of anti-angiogenic therapies. Other strategies such as vascular promotion or the induction of high endothelial venules are being studied now to improve cancer therapy. Bone morphogenetic protein 9 (BMP9) exerts a dual effect through the activin receptor-like kinase 1 (ALK1) receptor in blood vessel maturation or activation phase of angiogenesis. Thus, it is an interesting pathway to target in combination with chemotherapies or immunotherapies. This review manuscript explores the effect of the BMP9–ALK1 pathway in tumor angiogenesis and the possible usefulness of targeting this pathway in anti-angiogenesis, vascular normalization or vascular promotion therapies.Blanca Ayuso-ÍñigoLucía Méndez-GarcíaMiguel PericachoJosé M. Muñoz-FélixMDPI AGarticletumor angiogenesisbone morphogenetic protein 9ALK1cancer therapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5412, p 5412 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tumor angiogenesis bone morphogenetic protein 9 ALK1 cancer therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	tumor angiogenesis bone morphogenetic protein 9 ALK1 cancer therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Blanca Ayuso-Íñigo Lucía Méndez-García Miguel Pericacho José M. Muñoz-Félix The Dual Effect of the BMP9–ALK1 Pathway in Blood Vessels: An Opportunity for Cancer Therapy Improvement?
description	The improvement of cancer therapy efficacy, the extension of patient survival and the reduction of adverse side effects are major challenges in cancer research. Targeting blood vessels has been considered a promising strategy in cancer therapy. Since the tumor vasculature is disorganized, leaky and triggers immunosuppression and tumor hypoxia, several strategies have been studied to modify tumor vasculature for cancer therapy improvement. Anti-angiogenesis was first described as a mechanism to prevent the formation of new blood vessels and prevent the oxygen supply to tumor cells, showing numerous limitations. Vascular normalization using low doses of anti-angiogenic drugs was purposed to overcome the limitations of anti-angiogenic therapies. Other strategies such as vascular promotion or the induction of high endothelial venules are being studied now to improve cancer therapy. Bone morphogenetic protein 9 (BMP9) exerts a dual effect through the activin receptor-like kinase 1 (ALK1) receptor in blood vessel maturation or activation phase of angiogenesis. Thus, it is an interesting pathway to target in combination with chemotherapies or immunotherapies. This review manuscript explores the effect of the BMP9–ALK1 pathway in tumor angiogenesis and the possible usefulness of targeting this pathway in anti-angiogenesis, vascular normalization or vascular promotion therapies.
format	article
author	Blanca Ayuso-Íñigo Lucía Méndez-García Miguel Pericacho José M. Muñoz-Félix
author_facet	Blanca Ayuso-Íñigo Lucía Méndez-García Miguel Pericacho José M. Muñoz-Félix
author_sort	Blanca Ayuso-Íñigo
title	The Dual Effect of the BMP9–ALK1 Pathway in Blood Vessels: An Opportunity for Cancer Therapy Improvement?
title_short	The Dual Effect of the BMP9–ALK1 Pathway in Blood Vessels: An Opportunity for Cancer Therapy Improvement?
title_full	The Dual Effect of the BMP9–ALK1 Pathway in Blood Vessels: An Opportunity for Cancer Therapy Improvement?
title_fullStr	The Dual Effect of the BMP9–ALK1 Pathway in Blood Vessels: An Opportunity for Cancer Therapy Improvement?
title_full_unstemmed	The Dual Effect of the BMP9–ALK1 Pathway in Blood Vessels: An Opportunity for Cancer Therapy Improvement?
title_sort	dual effect of the bmp9–alk1 pathway in blood vessels: an opportunity for cancer therapy improvement?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0043a30176fb45b1b342110cadd8cd4f
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The Dual Effect of the BMP9–ALK1 Pathway in Blood Vessels: An Opportunity for Cancer Therapy Improvement?

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