Amniogenic somatopleure: a novel origin of multiple cell lineages contributing to the cardiovascular system

Abstract The somatopleure is the amniotic primordium in amniote development, but its boundary to the embryonic body at early embryonic stages and the fate of cells constituting this structure are not well characterized. It also remains unclear how cells behave during the demarcation between intra- a...

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Autores principales:	Rieko Asai, Yuka Haneda, Daiki Seya, Yuichiro Arima, Kimiko Fukuda, Yukiko Kurihara, Sachiko Miyagawa-Tomita, Hiroki Kurihara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0045064f78ab43f3986fcd8c196fb58a
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spelling	oai:doaj.org-article:0045064f78ab43f3986fcd8c196fb58a2021-12-02T16:06:47ZAmniogenic somatopleure: a novel origin of multiple cell lineages contributing to the cardiovascular system10.1038/s41598-017-08305-22045-2322https://doaj.org/article/0045064f78ab43f3986fcd8c196fb58a2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08305-2https://doaj.org/toc/2045-2322Abstract The somatopleure is the amniotic primordium in amniote development, but its boundary to the embryonic body at early embryonic stages and the fate of cells constituting this structure are not well characterized. It also remains unclear how cells behave during the demarcation between intra- and extra-embryonic tissues. Here we identify cellular alignments, which indicate two streams towards the sites of dorsal amniotic closure and ventral thoracic wall formation. A subpopulation of mesodermal cells moving ventrally from the somatopleural region adjacent to the base of the head fold enter the body of the embryo and distribute to the thoracic wall, pharyngeal arches and heart. These cells are induced to differentiate into vascular endothelial cells and cardiomyocytes possibly by FGF and BMP signaling, respectively. These results indicate that the somatopleure acting as the amniotic primordium also serves as a source of embryonic cells, which may contribute to cardiovascular development.Rieko AsaiYuka HanedaDaiki SeyaYuichiro ArimaKimiko FukudaYukiko KuriharaSachiko Miyagawa-TomitaHiroki KuriharaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rieko Asai Yuka Haneda Daiki Seya Yuichiro Arima Kimiko Fukuda Yukiko Kurihara Sachiko Miyagawa-Tomita Hiroki Kurihara Amniogenic somatopleure: a novel origin of multiple cell lineages contributing to the cardiovascular system
description	Abstract The somatopleure is the amniotic primordium in amniote development, but its boundary to the embryonic body at early embryonic stages and the fate of cells constituting this structure are not well characterized. It also remains unclear how cells behave during the demarcation between intra- and extra-embryonic tissues. Here we identify cellular alignments, which indicate two streams towards the sites of dorsal amniotic closure and ventral thoracic wall formation. A subpopulation of mesodermal cells moving ventrally from the somatopleural region adjacent to the base of the head fold enter the body of the embryo and distribute to the thoracic wall, pharyngeal arches and heart. These cells are induced to differentiate into vascular endothelial cells and cardiomyocytes possibly by FGF and BMP signaling, respectively. These results indicate that the somatopleure acting as the amniotic primordium also serves as a source of embryonic cells, which may contribute to cardiovascular development.
format	article
author	Rieko Asai Yuka Haneda Daiki Seya Yuichiro Arima Kimiko Fukuda Yukiko Kurihara Sachiko Miyagawa-Tomita Hiroki Kurihara
author_facet	Rieko Asai Yuka Haneda Daiki Seya Yuichiro Arima Kimiko Fukuda Yukiko Kurihara Sachiko Miyagawa-Tomita Hiroki Kurihara
author_sort	Rieko Asai
title	Amniogenic somatopleure: a novel origin of multiple cell lineages contributing to the cardiovascular system
title_short	Amniogenic somatopleure: a novel origin of multiple cell lineages contributing to the cardiovascular system
title_full	Amniogenic somatopleure: a novel origin of multiple cell lineages contributing to the cardiovascular system
title_fullStr	Amniogenic somatopleure: a novel origin of multiple cell lineages contributing to the cardiovascular system
title_full_unstemmed	Amniogenic somatopleure: a novel origin of multiple cell lineages contributing to the cardiovascular system
title_sort	amniogenic somatopleure: a novel origin of multiple cell lineages contributing to the cardiovascular system
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0045064f78ab43f3986fcd8c196fb58a
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Amniogenic somatopleure: a novel origin of multiple cell lineages contributing to the cardiovascular system

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