Potential role of IFN-γ and IL-5 in sepsis prediction of preterm neonates

Not fully maturated immune system in preterm neonates may contribute to the increased susceptibility to infection. The levels of some cytokines can be useful in the prediction and diagnosis of sepsis in premature neonates. In the present study, we evaluated the potential predictive role of IFN-γ and...

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Autores principales:	Vucic Jelena, Vucic Miodrag, Stankovic Tatjana, Stamenkovic Hristina, Stankovic Sandra, Zlatanovic Dragan
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	preterm neonates sepsis cytokines prediction Medicine R
Acceso en línea:	https://doaj.org/article/00475ba38252426d8ac68319b348ebf0
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spelling	oai:doaj.org-article:00475ba38252426d8ac68319b348ebf02021-12-05T14:10:53ZPotential role of IFN-γ and IL-5 in sepsis prediction of preterm neonates2391-546310.1515/med-2021-0206https://doaj.org/article/00475ba38252426d8ac68319b348ebf02021-01-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0206https://doaj.org/toc/2391-5463Not fully maturated immune system in preterm neonates may contribute to the increased susceptibility to infection. The levels of some cytokines can be useful in the prediction and diagnosis of sepsis in premature neonates. In the present study, we evaluated the potential predictive role of IFN-γ and IL-5 in cord and venous blood, together with the determination of C-reactive protein and procalcitonin (PCT) for sepsis development in premature neonates. A total of 80 participants were included. The laboratory results and clinical histories showed that 21 participants had sepsis. Early onset sepsis was detected in 3 patients while late onset sepsis was observed in 18 participants. The venous plasma levels of IFN-γ and PCT was markedly increased in sepsis groups when compared to the participants without sepsis. On the other hand, levels of IL-5 did not significantly change in the evaluated groups of sepsis and in the control group of participants. Simultaneously, plasma venous levels were not altered in any of the evaluated groups. Obtained findings suggest that venous plasma levels of IFN-γ, rather than levels of IFN-γ in cord blood plasma, and PCT may have predictive potential for sepsis development in preterm neonates. Further studies are necessary to get more comprehension of the complex function of cytokines for sepsis development in preterm neonates.Vucic JelenaVucic MiodragStankovic TatjanaStamenkovic HristinaStankovic SandraZlatanovic DraganDe Gruyterarticlepreterm neonatessepsiscytokinespredictionMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 139-145 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	preterm neonates sepsis cytokines prediction Medicine R
spellingShingle	preterm neonates sepsis cytokines prediction Medicine R Vucic Jelena Vucic Miodrag Stankovic Tatjana Stamenkovic Hristina Stankovic Sandra Zlatanovic Dragan Potential role of IFN-γ and IL-5 in sepsis prediction of preterm neonates
description	Not fully maturated immune system in preterm neonates may contribute to the increased susceptibility to infection. The levels of some cytokines can be useful in the prediction and diagnosis of sepsis in premature neonates. In the present study, we evaluated the potential predictive role of IFN-γ and IL-5 in cord and venous blood, together with the determination of C-reactive protein and procalcitonin (PCT) for sepsis development in premature neonates. A total of 80 participants were included. The laboratory results and clinical histories showed that 21 participants had sepsis. Early onset sepsis was detected in 3 patients while late onset sepsis was observed in 18 participants. The venous plasma levels of IFN-γ and PCT was markedly increased in sepsis groups when compared to the participants without sepsis. On the other hand, levels of IL-5 did not significantly change in the evaluated groups of sepsis and in the control group of participants. Simultaneously, plasma venous levels were not altered in any of the evaluated groups. Obtained findings suggest that venous plasma levels of IFN-γ, rather than levels of IFN-γ in cord blood plasma, and PCT may have predictive potential for sepsis development in preterm neonates. Further studies are necessary to get more comprehension of the complex function of cytokines for sepsis development in preterm neonates.
format	article
author	Vucic Jelena Vucic Miodrag Stankovic Tatjana Stamenkovic Hristina Stankovic Sandra Zlatanovic Dragan
author_facet	Vucic Jelena Vucic Miodrag Stankovic Tatjana Stamenkovic Hristina Stankovic Sandra Zlatanovic Dragan
author_sort	Vucic Jelena
title	Potential role of IFN-γ and IL-5 in sepsis prediction of preterm neonates
title_short	Potential role of IFN-γ and IL-5 in sepsis prediction of preterm neonates
title_full	Potential role of IFN-γ and IL-5 in sepsis prediction of preterm neonates
title_fullStr	Potential role of IFN-γ and IL-5 in sepsis prediction of preterm neonates
title_full_unstemmed	Potential role of IFN-γ and IL-5 in sepsis prediction of preterm neonates
title_sort	potential role of ifn-γ and il-5 in sepsis prediction of preterm neonates
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/00475ba38252426d8ac68319b348ebf0
work_keys_str_mv	AT vucicjelena potentialroleofifngandil5insepsispredictionofpretermneonates AT vucicmiodrag potentialroleofifngandil5insepsispredictionofpretermneonates AT stankovictatjana potentialroleofifngandil5insepsispredictionofpretermneonates AT stamenkovichristina potentialroleofifngandil5insepsispredictionofpretermneonates AT stankovicsandra potentialroleofifngandil5insepsispredictionofpretermneonates AT zlatanovicdragan potentialroleofifngandil5insepsispredictionofpretermneonates
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Potential role of IFN-γ and IL-5 in sepsis prediction of preterm neonates

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