RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

Resistance to chemotherapy is a serious issue that can be influenced by RNA epigenetics and chromatin structure. Here, the authors show in leukaemia cells that RNA 5-methylcytosine (RNA:m5C) and RNA:m5C methyltransferases (RCMTs) mediate chromatin structures that can modulate 5-Azacitidine response...

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Autores principales:	Jason X. Cheng, Li Chen, Yuan Li, Adam Cloe, Ming Yue, Jiangbo Wei, Kenneth A. Watanabe, Jamile M. Shammo, John Anastasi, Qingxi J. Shen, Richard A. Larson, Chuan He, Michelle M. Le Beau, James W. Vardiman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0047ac9534df42779c7119999f42d1bf
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spelling	oai:doaj.org-article:0047ac9534df42779c7119999f42d1bf2021-12-02T17:32:48ZRNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia10.1038/s41467-018-03513-42041-1723https://doaj.org/article/0047ac9534df42779c7119999f42d1bf2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03513-4https://doaj.org/toc/2041-1723Resistance to chemotherapy is a serious issue that can be influenced by RNA epigenetics and chromatin structure. Here, the authors show in leukaemia cells that RNA 5-methylcytosine (RNA:m5C) and RNA:m5C methyltransferases (RCMTs) mediate chromatin structures that can modulate 5-Azacitidine response and resistance.Jason X. ChengLi ChenYuan LiAdam CloeMing YueJiangbo WeiKenneth A. WatanabeJamile M. ShammoJohn AnastasiQingxi J. ShenRichard A. LarsonChuan HeMichelle M. Le BeauJames W. VardimanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jason X. Cheng Li Chen Yuan Li Adam Cloe Ming Yue Jiangbo Wei Kenneth A. Watanabe Jamile M. Shammo John Anastasi Qingxi J. Shen Richard A. Larson Chuan He Michelle M. Le Beau James W. Vardiman RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia
description	Resistance to chemotherapy is a serious issue that can be influenced by RNA epigenetics and chromatin structure. Here, the authors show in leukaemia cells that RNA 5-methylcytosine (RNA:m5C) and RNA:m5C methyltransferases (RCMTs) mediate chromatin structures that can modulate 5-Azacitidine response and resistance.
format	article
author	Jason X. Cheng Li Chen Yuan Li Adam Cloe Ming Yue Jiangbo Wei Kenneth A. Watanabe Jamile M. Shammo John Anastasi Qingxi J. Shen Richard A. Larson Chuan He Michelle M. Le Beau James W. Vardiman
author_facet	Jason X. Cheng Li Chen Yuan Li Adam Cloe Ming Yue Jiangbo Wei Kenneth A. Watanabe Jamile M. Shammo John Anastasi Qingxi J. Shen Richard A. Larson Chuan He Michelle M. Le Beau James W. Vardiman
author_sort	Jason X. Cheng
title	RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia
title_short	RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia
title_full	RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia
title_fullStr	RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia
title_full_unstemmed	RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia
title_sort	rna cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0047ac9534df42779c7119999f42d1bf
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RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

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