Intraocular pressure dynamics with prostaglandin analogs: a clinical application of water-drinking test

Pelin Özyol,1 Erhan Özyol,1 Ercan Baldemir2 1Ophthalmology Department, 2Biostatistics Department, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey Aim: To evaluate the clinical applicability of the water-drinking test in treatment-naive primary open-angle glaucom...

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Autores principales:	Özyol P, Özyol E, Baldemir E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Glaucoma intraocular pressure water-drinking test prostaglandin analogue intraocular pressure fluctuation. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/004ca7ff2b5342fe929abf596e8d21ee
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spelling	oai:doaj.org-article:004ca7ff2b5342fe929abf596e8d21ee2021-12-02T00:41:23ZIntraocular pressure dynamics with prostaglandin analogs: a clinical application of water-drinking test1177-5483https://doaj.org/article/004ca7ff2b5342fe929abf596e8d21ee2016-07-01T00:00:00Zhttps://www.dovepress.com/intraocular-pressure-dynamics-with-prostaglandin-analogs-a-clinical-ap-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Pelin Özyol,1 Erhan Özyol,1 Ercan Baldemir2 1Ophthalmology Department, 2Biostatistics Department, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey Aim: To evaluate the clinical applicability of the water-drinking test in treatment-naive primary open-angle glaucoma patients. Methods: Twenty newly diagnosed primary open-angle glaucoma patients and 20 healthy controls were enrolled in this prospective study. The water-drinking test was performed at baseline and 6 weeks and 3 months after prostaglandin analog treatment. Peak and fluctuation of intraocular pressure (IOP) measurements obtained with the water-drinking test during follow-up were analyzed. Analysis of variance for repeated measures and paired and unpaired t-tests were used for statistical analysis. Results: The mean baseline IOP values in patients with primary open-angle glaucoma were 25.1±4.6 mmHg before prostaglandin analog treatment, 19.8±3.7 mmHg at week 6, and 17.9±2.2 mmHg at month 3 after treatment. The difference in mean baseline IOP of the water-drinking tests was statistically significant (P<0.001). At 6 weeks of prostaglandin analog treatment, two patients had high peak and fluctuation of IOP measurements despite a reduction in baseline IOP. After modifying treatment, patients had lower peak and fluctuation of IOP values at month 3 of the study. Conclusion: Peak and fluctuation of IOP in response to the water-drinking test were lower with prostaglandin analogs compared with before medication. The water-drinking test can represent an additional benefit in the management of glaucoma patients, especially by detecting higher peak and fluctuation of IOP values despite a reduced mean IOP. Therefore, it could be helpful as a supplementary method in monitoring IOP in the clinical practice. Keywords: glaucoma, intraocular pressure, water-drinking test, prostaglandin analog, intraocular pressure fluctuationÖzyol PÖzyol EBaldemir EDove Medical PressarticleGlaucomaintraocular pressurewater-drinking testprostaglandin analogueintraocular pressure fluctuation.OphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 1351-1356 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Glaucoma intraocular pressure water-drinking test prostaglandin analogue intraocular pressure fluctuation. Ophthalmology RE1-994
spellingShingle	Glaucoma intraocular pressure water-drinking test prostaglandin analogue intraocular pressure fluctuation. Ophthalmology RE1-994 Özyol P Özyol E Baldemir E Intraocular pressure dynamics with prostaglandin analogs: a clinical application of water-drinking test
description	Pelin Özyol,1 Erhan Özyol,1 Ercan Baldemir2 1Ophthalmology Department, 2Biostatistics Department, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey Aim: To evaluate the clinical applicability of the water-drinking test in treatment-naive primary open-angle glaucoma patients. Methods: Twenty newly diagnosed primary open-angle glaucoma patients and 20 healthy controls were enrolled in this prospective study. The water-drinking test was performed at baseline and 6 weeks and 3 months after prostaglandin analog treatment. Peak and fluctuation of intraocular pressure (IOP) measurements obtained with the water-drinking test during follow-up were analyzed. Analysis of variance for repeated measures and paired and unpaired t-tests were used for statistical analysis. Results: The mean baseline IOP values in patients with primary open-angle glaucoma were 25.1±4.6 mmHg before prostaglandin analog treatment, 19.8±3.7 mmHg at week 6, and 17.9±2.2 mmHg at month 3 after treatment. The difference in mean baseline IOP of the water-drinking tests was statistically significant (P<0.001). At 6 weeks of prostaglandin analog treatment, two patients had high peak and fluctuation of IOP measurements despite a reduction in baseline IOP. After modifying treatment, patients had lower peak and fluctuation of IOP values at month 3 of the study. Conclusion: Peak and fluctuation of IOP in response to the water-drinking test were lower with prostaglandin analogs compared with before medication. The water-drinking test can represent an additional benefit in the management of glaucoma patients, especially by detecting higher peak and fluctuation of IOP values despite a reduced mean IOP. Therefore, it could be helpful as a supplementary method in monitoring IOP in the clinical practice. Keywords: glaucoma, intraocular pressure, water-drinking test, prostaglandin analog, intraocular pressure fluctuation
format	article
author	Özyol P Özyol E Baldemir E
author_facet	Özyol P Özyol E Baldemir E
author_sort	Özyol P
title	Intraocular pressure dynamics with prostaglandin analogs: a clinical application of water-drinking test
title_short	Intraocular pressure dynamics with prostaglandin analogs: a clinical application of water-drinking test
title_full	Intraocular pressure dynamics with prostaglandin analogs: a clinical application of water-drinking test
title_fullStr	Intraocular pressure dynamics with prostaglandin analogs: a clinical application of water-drinking test
title_full_unstemmed	Intraocular pressure dynamics with prostaglandin analogs: a clinical application of water-drinking test
title_sort	intraocular pressure dynamics with prostaglandin analogs: a clinical application of water-drinking test
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/004ca7ff2b5342fe929abf596e8d21ee
work_keys_str_mv	AT ozyolp intraocularpressuredynamicswithprostaglandinanalogsaclinicalapplicationofwaterdrinkingtest AT ozyole intraocularpressuredynamicswithprostaglandinanalogsaclinicalapplicationofwaterdrinkingtest AT baldemire intraocularpressuredynamicswithprostaglandinanalogsaclinicalapplicationofwaterdrinkingtest
_version_	1718403534165114880

Intraocular pressure dynamics with prostaglandin analogs: a clinical application of water-drinking test

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