Visualization of white matter tracts using a non-diffusion weighted magnetic resonance imaging method: does intravenous gadolinium injection four hours prior to the examination affect the visualization of white matter tracts?

<h4>Objectives</h4>Visualization of white matter (WM)-tracts such as the corticospinal tract (CST), medial lemniscus (ML), and superior cerebellar peduncle (SCP) using delayed enhanced (DE)-heavily T2-weighted three-dimensional fluid-attenuated inversion-recovery (hT2w-3D-FLAIR) imaging...

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Autores principales:	Masahiro Yamazaki, Shinji Naganawa, Hisashi Kawai, Mitsuru Ikeda, Kiminori Bokura, Haruo Isoda, Tsutomu Nakashima
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/004d1fe4360f4743818ad7caca0773c8
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spelling	oai:doaj.org-article:004d1fe4360f4743818ad7caca0773c82021-11-18T08:28:23ZVisualization of white matter tracts using a non-diffusion weighted magnetic resonance imaging method: does intravenous gadolinium injection four hours prior to the examination affect the visualization of white matter tracts?1932-620310.1371/journal.pone.0091860https://doaj.org/article/004d1fe4360f4743818ad7caca0773c82014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24622649/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>Visualization of white matter (WM)-tracts such as the corticospinal tract (CST), medial lemniscus (ML), and superior cerebellar peduncle (SCP) using delayed enhanced (DE)-heavily T2-weighted three-dimensional fluid-attenuated inversion-recovery (hT2w-3D-FLAIR) imaging has recently been reported. In that report, all patients were clinically suspected of having Ménière's disease, because DE-hT2w-3D-FLAIR imaging of the inner ear has been reported to separately visualize perilymph and endolymph fluid and can identify the presence of endolymphatic hydrops. Therefore, the previous report could not rule out the possible effect of delayed enhancement. From this perspective, the purpose of this study was to elucidate if the use of gadolinium affects the visualization of WM-tracts on hT2w-3D-FLAIR.<h4>Materials and methods</h4>The records of nine patients with suspected Ménière's disease who underwent plain (P) and DE-hT2w-3D-FLAIR by 3-Tesla were retrospectively analyzed. The regions of interest were set on the CST, ML, and SCP, and on contiguous brain parenchyma: The thalamus (Th), pontine parenchyma (PP), and cerebellar parenchyma (CP), respectively. The signal intensity ratio between each WM-tract and the relevant contiguous brain parenchyma was calculated for both P- and DE-hT2w-3D-FLAIR images, and statistically compared using paired t-tests.<h4>Results</h4>The CST/Th signal intensity ratio was 3.75±0.67 on P-hT2w-3D-FLAIR and 3.62±0.50 on DE-hT2w-3D-FLAIR (p = 0.24). The ML/PP signal intensity ratio was 2.19±0.59 on P-hT2w-3D-FLAIR and 2.08±0.53 on DE-hT2w-3D-FLAIR (p = 0.25). The SCP/CP signal intensity ratio was 4.08±0.91 on P-hT2w-3D-FLAIR and 4.04±0.96 on DE-hT2w-3D-FLAIR (p = 0.43). There were no significant differences in the signal intensity ratios between P- and DE-hT2w-3D-FLAIR images.<h4>Conclusions</h4>The use of gadolinium is not necessary for visualization of WM-tracts using hT2w-3D-FLAIR, and P-hT2w-3D-FLAIR without gadolinium may have future clinical applications as an imaging procedure.Masahiro YamazakiShinji NaganawaHisashi KawaiMitsuru IkedaKiminori BokuraHaruo IsodaTsutomu NakashimaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e91860 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masahiro Yamazaki Shinji Naganawa Hisashi Kawai Mitsuru Ikeda Kiminori Bokura Haruo Isoda Tsutomu Nakashima Visualization of white matter tracts using a non-diffusion weighted magnetic resonance imaging method: does intravenous gadolinium injection four hours prior to the examination affect the visualization of white matter tracts?
description	<h4>Objectives</h4>Visualization of white matter (WM)-tracts such as the corticospinal tract (CST), medial lemniscus (ML), and superior cerebellar peduncle (SCP) using delayed enhanced (DE)-heavily T2-weighted three-dimensional fluid-attenuated inversion-recovery (hT2w-3D-FLAIR) imaging has recently been reported. In that report, all patients were clinically suspected of having Ménière's disease, because DE-hT2w-3D-FLAIR imaging of the inner ear has been reported to separately visualize perilymph and endolymph fluid and can identify the presence of endolymphatic hydrops. Therefore, the previous report could not rule out the possible effect of delayed enhancement. From this perspective, the purpose of this study was to elucidate if the use of gadolinium affects the visualization of WM-tracts on hT2w-3D-FLAIR.<h4>Materials and methods</h4>The records of nine patients with suspected Ménière's disease who underwent plain (P) and DE-hT2w-3D-FLAIR by 3-Tesla were retrospectively analyzed. The regions of interest were set on the CST, ML, and SCP, and on contiguous brain parenchyma: The thalamus (Th), pontine parenchyma (PP), and cerebellar parenchyma (CP), respectively. The signal intensity ratio between each WM-tract and the relevant contiguous brain parenchyma was calculated for both P- and DE-hT2w-3D-FLAIR images, and statistically compared using paired t-tests.<h4>Results</h4>The CST/Th signal intensity ratio was 3.75±0.67 on P-hT2w-3D-FLAIR and 3.62±0.50 on DE-hT2w-3D-FLAIR (p = 0.24). The ML/PP signal intensity ratio was 2.19±0.59 on P-hT2w-3D-FLAIR and 2.08±0.53 on DE-hT2w-3D-FLAIR (p = 0.25). The SCP/CP signal intensity ratio was 4.08±0.91 on P-hT2w-3D-FLAIR and 4.04±0.96 on DE-hT2w-3D-FLAIR (p = 0.43). There were no significant differences in the signal intensity ratios between P- and DE-hT2w-3D-FLAIR images.<h4>Conclusions</h4>The use of gadolinium is not necessary for visualization of WM-tracts using hT2w-3D-FLAIR, and P-hT2w-3D-FLAIR without gadolinium may have future clinical applications as an imaging procedure.
format	article
author	Masahiro Yamazaki Shinji Naganawa Hisashi Kawai Mitsuru Ikeda Kiminori Bokura Haruo Isoda Tsutomu Nakashima
author_facet	Masahiro Yamazaki Shinji Naganawa Hisashi Kawai Mitsuru Ikeda Kiminori Bokura Haruo Isoda Tsutomu Nakashima
author_sort	Masahiro Yamazaki
title	Visualization of white matter tracts using a non-diffusion weighted magnetic resonance imaging method: does intravenous gadolinium injection four hours prior to the examination affect the visualization of white matter tracts?
title_short	Visualization of white matter tracts using a non-diffusion weighted magnetic resonance imaging method: does intravenous gadolinium injection four hours prior to the examination affect the visualization of white matter tracts?
title_full	Visualization of white matter tracts using a non-diffusion weighted magnetic resonance imaging method: does intravenous gadolinium injection four hours prior to the examination affect the visualization of white matter tracts?
title_fullStr	Visualization of white matter tracts using a non-diffusion weighted magnetic resonance imaging method: does intravenous gadolinium injection four hours prior to the examination affect the visualization of white matter tracts?
title_full_unstemmed	Visualization of white matter tracts using a non-diffusion weighted magnetic resonance imaging method: does intravenous gadolinium injection four hours prior to the examination affect the visualization of white matter tracts?
title_sort	visualization of white matter tracts using a non-diffusion weighted magnetic resonance imaging method: does intravenous gadolinium injection four hours prior to the examination affect the visualization of white matter tracts?
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/004d1fe4360f4743818ad7caca0773c8
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Visualization of white matter tracts using a non-diffusion weighted magnetic resonance imaging method: does intravenous gadolinium injection four hours prior to the examination affect the visualization of white matter tracts?

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